Publications
55 results found
Plonczak A, DiMarco A, Gujral D, et al., 2017, Breast cancer metastases to the thyroid gland - An uncommon sentinel for diffuse metastatic disease: A case report and literature review., Journal of Medical Case Reports, Vol: 11, ISSN: 1752-1947
BackgroundMetastases to the thyroid are rare. The most common primary cancer to metastasize to the thyroid is renal cell carcinoma, followed by malignancies of the gastrointestinal tract, lungs, and skin, with breast cancer metastases to the thyroid being rare. Overall, the outcomes in malignancies that have metastasized to the thyroid are poor. There are no prospective studies addressing the role of surgery in metastatic disease of the thyroid. Isolated thyroidectomy has been proposed as a local disease control option to palliate and prevent the potential morbidity of tumor extension related to the airway. Here, we present a case of a patient with breast cancer metastases to the thyroid gland and discuss the role of thyroidectomy in the context of the current literature.Case presentationA 62-year-old Afro-Caribbean woman was diagnosed as having bilateral breast carcinoma in 2004, for which she underwent bilateral mastectomy. The pathology revealed multifocal disease on the right, T2N0(0/20)M0 grade 1 and 2 invasive ductal carcinoma, and on the left side, T3N1(2/18)M0 grade 1 invasive ductal carcinoma. Surgery was followed by adjuvant chemotherapy and regional radiotherapy. The disease was under control on hormonal therapy until 2016, when she developed cervical lymphadenopathy. The fine-needle aspiration cytology of the thyroid was reported as papillary thyroid cancer; and the fine-needle biopsy of the left lateral nodal disease was more suggestive of breast malignancy. She underwent a total thyroidectomy and a clearance of the central compartment lymph nodes and a biopsy of the lateral nodal disease. The histopathological analysis was consistent with metastatic breast cancer in the thyroid and lymph nodes with no evidence of a primary thyroid malignancy.ConclusionsA past history of a malignancy elsewhere should raise the index of suspicion of metastatic disease in patients presenting with thyroid lumps with or without cervical lymphadenopathy. Detection of metasta
Di Marco AN, Chotalia R, Bloxham R, et al., 2017, Can near infrared autofluorescent imaging prevent inadvertent parathyroidectomy? A pilot study, British Association of Endocrine and Thyroid Surgeons
Di Marco AN, Halle Y, Sam A, et al., 2017, Subclinical hypercortisolaemia in patients undergoing adrenal surgery: What is the clinical relevance?, British Association of Endocrine and Thyroid Surgeons
Di Marco AN, Palazzo F, 2017, Goitre and Thyroid Cancer, Medicine, ISSN: 1357-3039
Di Marco AN, Jeyakumar J, Pratt PJ, et al., 2016, Evaluating a novel 3D stereoscopic visual display for transanal endoscopic surgery: a randomized controlled crossover study, Annals of Surgery, Vol: 263, Pages: 36-42, ISSN: 1528-1140
King HK, Shang JS, Liu JL, et al., 2015, Micro-IGES Robot for Transanal Robotic Microsurgery., In The Hamlyn Symposium on Medical Robotics.
Cundy TP, Di Marco AN, Hamady M, et al., 2014, Giant left paraduodenal hernia., BMJ Case Rep, Vol: 2014
Left paraduodenal hernia (LPDH) is a retrocolic internal hernia of congenital origin that develops through the fossa of Landzert, and extends into the descending mesocolon and left portion of the transverse mesocolon. It carries significant overall risk of mortality, yet delay in diagnosis is not unusual due to subtle and elusive features. Familiarisation with the embryological and anatomical features of this rare hernia is essential for surgical management. This is especially important with respect to vascular anatomy as major mesenteric vessels form intimate relationships with the ventral rim and anterior portion of the hernia. As an illustrative case, we describe our experience with a striking example of LPDH, particularly focusing on the inherent diagnostic challenges and associated critical vascular anatomy. We advocate the role of diagnostic laparoscopy; however caution that decision to safely proceed with laparoscopic repair must occur only with confident identification of the vascular anatomy involved.
Hughes-Hallett A, Pratt P, Mayer E, et al., 2014, Intraoperative Ultrasound Overlay in Robot-assisted Partial Nephrectomy: First Clinical Experience, European Urology, Vol: 65, Pages: 671-672, ISSN: 1421-993X
Intraoperative ultrasound facilitates the localisation of partially or entirely endophytic renal tumours during laparoscopic or robot-assisted partial nephrectomy (RAPN) [1]. A current limitation of intraoperative ultrasound is the requirement on the surgeon to relate the subsurface ultrasound image to the separate endoscopic view. Here we present the first clinical experience of live registered intraoperative ultrasound overlay.Registered ultrasound overlay was achieved using an approach previously described by our group, where the use of ultrasound in an ex vivo model for transanal microsurgery was examined [2]. This method of live image registration can be best described as a three-step process of calibration, image registration, and finally image overlay, and it has demonstrated a registration accuracy <0.5 mm [2]. Table 1 summarises the system hardware.
Granados A, Hald N, Di Marco A, et al., 2014, Real-time visualisation and analysis of internal examinations - Seeing the unseen, Pages: 617-625, ISSN: 0302-9743
Internal examinations such as Digital Rectal Examination (DRE) and bimanual Vaginal Examination (BVE) are routinely performed for early diagnosis of cancer and other diseases. Although they are recognised as core skills to be taught on a medical curriculum, they are difficult to learn and teach due to their unsighted nature. We present a framework that combines a visualisation and analysis tool with position and pressure sensors to enable the study of internal examinations and provision of real-time feedback. This approach is novel as it allows for real-time continuous trajectory and pressure data to be obtained for the complete examination, which may be used for teaching and assessment. Experiments were conducted performing DRE and BVE on benchtop models, and BVE on Gynaecological Teaching Assistants (GTA). The results obtained suggest that the proposed methodology may provide an insight into what constitutes an adequate DRE or BVE, provide real-time feedback tools for learning and assessment, and inform haptics-based simulator design. © 2014 Springer International Publishing.
Granados A, Hald N, Di Marco A, et al., 2014, Real-Time Visualisation and Analysis of Internal Examinations - Seeing the Unseen, MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2014, PT I, Vol: 8673, Pages: 617-+, ISSN: 0302-9743
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- Citations: 4
Marcus HJ, Hughes-Hallett A, Cundy TP, et al., 2013, Comparative Effectiveness of 3-D versus 2-D and HD versus SD Neuroendoscopy: A Preclinical Randomized Crossover Study, Neurosurgery
Di Marco AN, Lee HA, Darzi AW, 2013, Foundation year one knowledge of NHS structure and finances: A questionnaire study., Int J Surg, Vol: 11
Clancy NT, Stoyanov D, James DRC, et al., 2012, Multispectral image alignment using a three channel endoscope <i>in vivo</i> during minimally invasive surgery, BIOMEDICAL OPTICS EXPRESS, Vol: 3, Pages: 2567-2578, ISSN: 2156-7085
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- Citations: 23
di Marco AN, Purkayastha S, Zacharakis E, 2012, Intussusception of the small bowel secondary to an enterolith from a jejunal diverticulum., Updates Surg, Vol: 64, Pages: 231-233, ISSN: 2038-131X
We report a case of acute, small bowel obstruction secondary to intussusception caused by an enterolith from a jejunal diverticulum, in an elderly female with a history of chronic, intermittent abdominal pain. Diagnostic work-up of the patient included a computed tomographic (CT) scan which demonstrated the intussusception, but not the enterolith, which was characteristically radiolucent. A laparotomy was performed and the enterolith was found and delivered. A fistula between the gallbladder and small bowel was sought, but not found. Multiple diverticulae were found throughout the small bowel. Although small bowel diverticulosis is rare, it should be considered in the differential diagnosis of the acute abdomen and chronic abdominal pain, especially in those with known colonic diverticulosis, in whom this condition is more common.
Sidhu R, Weir-McCall J, Cochennec F, et al., 2012, Evaluation of an Electromagnetic 3D Navigation System to Facilitate Endovascular Tasks: A Feasibility Study, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 43, Pages: 22-29, ISSN: 1078-5884
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- Citations: 18
Win Tun Latt, Tou Pin Chang, di Marco A, et al., 2012, A hand-held instrument for in vivo probe-based confocal laser endomicroscopy during minimally invasive surgery, Intelligent Robots and Systems (IROS), 2012 IEEE/RSJ International Conference on, Pages: 1982-1987, ISSN: 2153-0858
Kwasnicki RM, Lewis TM, Jordan SJ, et al., 2012, Junior doctors about to start core surgical training are no more technically prepared than medical students, International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI), Publisher: WILEY-BLACKWELL, Pages: 139-139, ISSN: 0007-1323
Pratt P, Di Marco A, Payne C, et al., 2012, Intraoperative ultrasound guidance for transanal endoscopic microsurgery, Med Image Comput Comput Assist Interv, Vol: 15, Pages: 463-470
Local excision of rectal cancer with transanal endoscopic microsurgery has proved to be a viable alternative to conventional, more radical techniques, but the reduced sensory experience presents significant challenges for the surgeon. Accurate identification and complete removal of lesions and subsurface targets is currently a difficult task, often exacerbated by intraoperative tissue deformation. This work describes novel ultrasound calibration and effective visualisation methods designed to meet these requirements, relying solely on optical measurements and pattern tracking. Detailed quantitative phantom and porcine validation experiments confirm that the technique is both practical and an accurate means for assessing lesion thickness intraoperatively, leading directly to human clinical trials.
Latt WT, Chang TP, Di Marco A, et al., 2012, A Hand-held Instrument for in vivo Probe-based Confocal Laser Endomicroscopy during Minimally Invasive Surgery, 25th IEEE\RSJ International Conference on Intelligent Robots and Systems (IROS), Publisher: IEEE, Pages: 1975-1980, ISSN: 2153-0858
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- Citations: 1
Newton RC, Noonan D, Payne C, et al., 2011, Probe tip contact force and bowel distension affect crypt morphology during confocal endomicroscopy, Publisher: BMJ Publishing Group Ltd and British Society of Gastroenterology, Pages: A12-A13
Di Marco A, Purkayastha S, Paraskeva P, et al., 2010, Intussuscepted mucocoele of the appendix secondary to mucinous cystadenoma, ANZ JOURNAL OF SURGERY, Vol: 80, Pages: 294-294, ISSN: 1445-1433
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- Citations: 1
Riga CV, Bicknell CD, Di Marco A, et al., 2010, NAVIGATION & ROBOTIC TECHNIQUES IN ENDOVASCULAR SURGERY, CONTROVERSIES AND UPDATES IN VASCULAR SURGERY 2010, Editors: Becquemin, Alimi, Gerard, Publisher: EDIZIONI MINERVA MEDICA, Pages: 144-149, ISBN: 978-88-7711-663-5
Biers SM, Di Marco A, Mostafid AH, 2007, Case report: differential diagnosis of isolated iliac lymphadenopathy following Bacillus Calmette-Guerin treatment for high-risk superficial bladder cancer, INTERNATIONAL UROLOGY AND NEPHROLOGY, Vol: 39, Pages: 1039-1041, ISSN: 0301-1623
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- Citations: 1
Andreoli A, Melchiorri G, Brozzi M, et al., 2003, Effect of different sports on body cell mass in highly trained athletes, 6th International Symposium on In Vivo Body Composition Studies, Publisher: SPRINGER-VERLAG ITALIA SRL, Pages: S122-S125, ISSN: 0940-5429
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- Citations: 41
Di Marco AN, Pal S, Whately-Smith C, et al., 2002, Evaluation of nocturnal pain symptoms in Parkinson's disease using the Parkinson's Disease Sleep Scale. A case control study, 7th International Congress of Parkinsons Disease and Movement Disorders, Publisher: WILEY-LISS, Pages: S224-S224, ISSN: 0885-3185
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