Imperial College London
Alternate

Dr Alex Digesu

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3312 1752a.digesu CV

 
 
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Location

 

Urogynaecology DepartmentCambridge WingSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

160 results found

Asfour V, Digesu GA, Ford A, Fernando R, Khullar Vet al., 2018, Re: Ultrasound bladder wall thickness and detrusor overactivity: a multicentre test accuracy study Is it fair to assess new imaging techniques against a poor gold standard?, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 125, Pages: 395-395, ISSN: 1470-0328

Journal article

Ali I, Swift S, Digesu GA, 2018, Surgical management of pelvic organ prolapse and stress urinary incontinence: where are we now?, International Urogynecology Journal, Vol: 29, Pages: 1-2, ISSN: 0937-3462

Journal article

Digesu GA, Swift S, Handley V, 2017, Informed consent checklists for midurethral slings: a common-sense approach., Int Urogynecol J, Vol: 28, Pages: 1639-1643

INTRODUCTION AND HYPOTHESIS: Following the US Food and Drug Administration's (FDA's) warning about the use of transvaginal mesh to treat pelvic organ prolapse (POP) and the use of single-incision slings to treat incontinence, the number of lawsuits for medical negligence regarding the use of any polypropylene mesh in the vagina has increased tremendously. METHODS: This same FDA document did not question the use of polypropylene midurethral slings and polypropylene for sacrocolpopexies. Surprisingly, despite all the evidence and recommendations from respected international scientific societies, we are constantly being called upon by our patients to defend the use of midurethral slings. The most common reasons for the new rash of medicolegal proceedings involving midurethral slings has to do with "breach of duties" resulting from undisclosed postoperative complications on the consent form and/or the lack of information in the medical records confirming that all possible alternative treatment options were presented to and discussed with the patient. RESULTS: One response to these lawsuits involves the addition of preoperative checklists when performing informed consent with patients electing surgical correction of stress urinary incontinence (SUI). CONCLUSIONS: This clinical opinion provides an expert clinician's perspectives and legal point of view on this controversial topic and discusses the role of a preoperative checklist supplementary to the standard informed consent form.

Journal article

Digesu GA, Swift S, 2017, Laser treatment in urogynaecology and the myth of the scientific evidence., Int Urogynecol J, Vol: 28, Pages: 1443-1444

Journal article

Digesu GA, Gargasole C, Hendricken C, Gore M, Kocjancic E, Khullar V, Rosier PFet al., 2017, ICS Teaching Module: Ambulatory Urodynamic Monitoring, NEUROUROLOGY AND URODYNAMICS, Vol: 36, Pages: 364-367, ISSN: 0733-2467

Journal article

Veit-Rubin N, Cartwright R, Singh AU, Digesu GA, Fernando R, Khullar Vet al., 2016, Association between joint hypermobility and pelvic organ prolapse in women: a systematic review and meta-analysis, Publisher: SPRINGER LONDON LTD, Pages: 1469-1478, ISSN: 0937-3462

Conference paper

Da Silva AS, Digesu GA, Dell'Utri C, Fritsch H, Piffarotti P, Khullar Vet al., 2016, Do ultrasound findings of levator ani "avulsion" correlate with anatomical findings: A multicenter cadaveric study, NEUROUROLOGY AND URODYNAMICS, Vol: 35, Pages: 683-688, ISSN: 0733-2467

Journal article

Rzepka J, Zalewski K, Stefanowicz A, Khullar V, Swift S, Digesu GAet al., 2016, Validation of the Polish version of P-QoL questionnaire, GINEKOLOGIA POLSKA, Vol: 87, Pages: 477-483, ISSN: 0017-0011

Objective: Pelvic organ prolapse (POP) is a common morbidity that affects many women and significantly decreases qualityof life. The severity and the impact of the prolapse on the quality of life are important parameters in the management andfollow-up of affected patients. The aim of this validation study was to validate the Polish version of the Prolapse Qualityof Life questionnaire (P-QoL).Material and methods: The P-QOL questionnaire was translated into Polish and administered to women recruited fromtwo gynecological outpatient clinics (n = 231). Both symptomatic and asymptomatic women were included in the studyand examined in supine position using the Pelvic Organ Prolapse Quantification System (POP-Q). The validity was assessedby comparing symptom scores and quality-of-life scores between symptomatic and asymptomatic women.Results: A total number of 154 symptomatic and 77 asymptomatic women were included. There was a strong correlationbetween severity of the disease based on physical findings (POP-Q scale) and the P-QoL scores in main prolapse quality-of-lifedomains. The overall scores for each life domain were significantly different between symptomatic and asymptomaticwomen (p < 0.001). All the questions regarding symptoms showed significant differences (p < 0.001) between both groups.Conclusions: The Polish version of P-QoL is a valid, reliable, and easily comprehensible instrument to assess quality of lifeand symptoms in Polish-speaking women suffering from urogenital prolapse.

Journal article

Puccini F, Bhide A, Elneil S, Digesu GAet al., 2016, Sacral Neuromodulation: An Effective Treatment for Lower Urinary Tract Symptoms in Multiple Sclerosis EDITORIAL COMMENT, OBSTETRICAL & GYNECOLOGICAL SURVEY, Vol: 71, Pages: 401-403, ISSN: 0029-7828

Journal article

Zecca C, Panicari L, Disanto G, Maino P, Singh A, Digesu GA, Gobbi Cet al., 2016, Posterior tibial nerve stimulation in the management of lower urinary tract symptoms in patients with multiple sclerosis, INTERNATIONAL UROGYNECOLOGY JOURNAL, Vol: 27, Pages: 521-527, ISSN: 0937-3462

Journal article

Puccini F, Bhide A, Elneil S, Digesu GAet al., 2016, Sacral neuromodulation: an effective treatment for lower urinary tract symptoms in multiple sclerosis, INTERNATIONAL UROGYNECOLOGY JOURNAL, Vol: 27, Pages: 347-354, ISSN: 0937-3462

Journal article

Veit-Rubin N, Cartwright R, Esmail A, Digesu GA, Fernando R, Khullar Vet al., 2016, The location of pain and urgency sensations during cystometry., Neurourology and Urodynamics, ISSN: 1520-6777

AIMS: The relationship between bladder pain and urinary urgency sensations is poorly understood. We analyzed the relationship between locations and intensities of urgency and pain sensations felt during filling cystometry. METHODS: Participants completed the King's Health Questionnaire (KHQ) to indicate presence of bladder pain or urgency. During cystometry, participants scored the intensity of urgency and pain, both in the suprapubic and the urethral region, on a VAS scale of 0-10 at a baseline, at first desire, normal desire, strong desire to void, and at maximum cystometric capacity during filling. We allocated the participants to six groups; those reporting urgency or not, pain or not, both symptoms and neither. Friedman's Test was used to ascertain if all scores increased significantly, the Wilcoxon Signed Rank Test was used to demonstrate the difference between scores, and agreement for findings during cystometry was tested with Mann-Whitney U. RESULTS: A total of 68 women participated; 38 participants reported pain, 57 reported urgency, and 33 reported both symptoms. Pain and urgency scores significantly increased during cystometry (P < 0.0001). For participants reporting pain, suprapubic pain was rated significantly higher than urethral pain. Participants reporting both symptoms, felt more urgency than pain, and again pain more suprapubically than urethrally. Participants reporting only urgency scored suprapubic and urethral urgency similarly at all desires. CONCLUSIONS: Pain and urgency are well differentiated sensations and are felt at different locations although pain is seemingly easier localized. Neurourol. Urodynam. © 2016 Wiley Periodicals, Inc.

Journal article

Manriquez V, Guzman R, Naser M, Aguilera A, Narvaez S, Castro A, Swift S, Digesu GAet al., 2016, Transcutaneous posterior tibial nerve stimulation versus extended release oxybutynin in overactive bladder patients. A prospective randomized trial, European Journal of Obstetrics & Gynecology and Reproductive Biology, Vol: 196, Pages: 6-10, ISSN: 0301-2115

Introduction and hypothesisThe aim of this study was to evaluate the effectiveness of transcutaneous posterior tibial nerve stimulation (T.C. PTNS) versus extended release oxybutynin (E.R.O.) in patients with overactive bladder.Materials and methodsSeventy female patients were randomized to receive either 10 mg E.R.O. daily or T.C. PTNS, using a TENS machine program with the 20 Hz, 200 cycles/s, and normal stimulation setting for two 30-min sessions, each week for a 12-week period. Pre-treatment and after the 12-week intervention, each patient completed a 3-day voiding diary and a self-report quality of life questionnaire (OAB-q). Statistical analysis was performed using Stata V12.1.ResultsSixty-four patients completed the treatment protocol. There were no significant differences between study groups in terms of age, body mass index, past hormone replacement therapy, smoking habits, menopause status, and parity. Prior to treatment, there were also no significant differences in the analysis of the 3-day voiding diary or in the OAB-q questionnaire results. Following the 12-week study, there was a statistically significant reduction in frequency of urination, urgency episodes, and urge incontinent episodes compared to pre-treatment values. However, there were no significant differences in these values between intervention groups after 12-weeks of therapy. There was a similar improvement in OAB-q scores in both treatment groups following therapy, and the T.C. PTNS group showed a statistically significant improvement over the E.R.O. in domain 2 of the OAB-q questionnaire. The other two domains showed similar improvement in both study groups.ConclusionT.C. PTNS and E.R.O. demonstrated similar improvements in subjects with OAB in a 12-week study.

Journal article

Bhide AA, Puccini F, Bray R, Khullar V, Digesu GAet al., 2015, The pelvic floor muscle hyperalgesia (PFMH) scoring system: a new classification tool to assess women with chronic pelvic pain: multicentre pilot study of validity and reliability, EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, Vol: 193, Pages: 111-113, ISSN: 0301-2115

Journal article

Sorrentino F, Cartwright R, Digesu GA, Tolton L, Franklin L, Singh A, Greco P, Khullar Vet al., 2015, Associations Between Individual Lower Urinary Tract Symptoms and Bacteriuria in Random Urine Samples in Women, NEUROUROLOGY AND URODYNAMICS, Vol: 34, Pages: 429-433, ISSN: 0733-2467

Journal article

Digesu GA, Swift S, Puccini F, Manonai J, Khullar V, Fernando R, Contreras Ortiz O, Salvatore Set al., 2015, The FIGO assessment scoring system (FASS): a new holistic classification tool to assess women with pelvic floor dysfunction: validity and reliability, INTERNATIONAL UROGYNECOLOGY JOURNAL, Vol: 26, Pages: 859-864, ISSN: 0937-3462

Journal article

Singh A, Swift S, Khullar V, Digesu GAet al., 2015, Laser vaginal rejuvenation: not ready for prime time, INTERNATIONAL UROGYNECOLOGY JOURNAL, Vol: 26, Pages: 163-164, ISSN: 0937-3462

Journal article

Svihrova V, Svihra J, Luptak J, Swift S, Digesu GAet al., 2014, Disability-adjusted life years (DALYs) in general population with pelvic organ prolapse: a study based on the prolapse quality-of-life questionnaire (P-QOL), EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, Vol: 182, Pages: 22-26, ISSN: 0301-2115

Journal article

Digesu GA, Sadeghi P, Sharma S, Puccini F, Tubaro A, Fernando R, Khullar Vet al., 2014, The importance of cystoscopy and bladder biopsy in women with refractory overactive bladder: the urogynaecologist's point of view? (vol 169, pg 408, 2013), EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, Vol: 182, Pages: 261-261, ISSN: 0301-2115

Journal article

Da Silva A, Digesu A, Dell'Utri C, Piffarotti P, Fritsch H, Cartwright R, Khullar Vet al., 2014, DO ULTRASOUND FINDINGS OF LEVATOR ANI " AVULSION" CORRELATE WITH ANATOMICAL FINDINGS: A MULTICENTRE CADAVERIC STUDY, INTERNATIONAL UROGYNECOLOGY JOURNAL, Vol: 25, Pages: S43-S44, ISSN: 0937-3462

Journal article

Zecca C, Digesu GA, Robshaw P, Singh A, Elneil S, Gobbi Cet al., 2014, Maintenance Percutaneous Posterior Nerve Stimulation for Refractory Lower Urinary Tract Symptoms in Patients with Multiple Sclerosis: An Open Label, Multicenter, Prospective Study, JOURNAL OF UROLOGY, Vol: 191, Pages: 697-702, ISSN: 0022-5347

Journal article

Zecca C, Digesu GA, Robshaw P, Puccini F, Khullar V, Tubaro A, Gobbi Cet al., 2014, Motor and sensory responses after percutaneous tibial nerve stimulation in multiple sclerosis patients with lower urinary tract symptoms treated in daily practice, EUROPEAN JOURNAL OF NEUROLOGY, Vol: 21, Pages: 506-511, ISSN: 1351-5101

Journal article

Digesu G, Derpapas A, Vijaya G, Panayi D S H, Hendricken C, Fernando R, Khullar Vet al., 2014, ARE THE MEASUREMENTS OF WATER-FILLED AND AIR-CHARGED CATHETERS THE SAME IN URODYNAMICS?, Joint Meeting of the International-Continence-Society/International-Urogynecological-Association, Publisher: WILEY-BLACKWELL, Pages: 972-973, ISSN: 0733-2467

Conference paper

Digesu GA, 2014, Are the measurements of water-filled and air-charged catheters the same in urodynamics? Response to comments., Int Urogynecol J, Vol: 25, Pages: 149-149

Journal article

Digesu GA, Derpapas A, Robshaw P, Vijaya G, Hendricken C, Khullar Vet al., 2014, Are the measurements of water-filled and air-charged catheters the same in urodynamics?, INTERNATIONAL UROGYNECOLOGY JOURNAL, Vol: 25, Pages: 123-130, ISSN: 0937-3462

Journal article

Digesu GA, Derpapas A, Hewett S, Tubaro A, Puccini F, Fernando R, Khullar Vet al., 2013, Does the onset or bother of mixed urinary incontinence symptoms help in the urodynamic diagnosis?, EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, Vol: 171, Pages: 381-384, ISSN: 0301-2115

Journal article

Bhide AA, Cartwright R, Khullar V, Digesu GAet al., 2013, Biomarkers in overactive bladder (vol 24, pg 1065, 2013), INTERNATIONAL UROGYNECOLOGY JOURNAL, Vol: 24, Pages: 1775-1777, ISSN: 0937-3462

Journal article

Bhide AA, Puccini F, Khullar V, Elneil S, Digesu GAet al., 2013, Botulinum neurotoxin type A injection of the pelvic floor muscle in pain due to spasticity: a review of the current literature, INTERNATIONAL UROGYNECOLOGY JOURNAL, Vol: 24, Pages: 1429-1434, ISSN: 0937-3462

Journal article

Bhide AA, Cartwright R, Khullar V, Digesu GAet al., 2013, Biomarkers in overactive bladder, INTERNATIONAL UROGYNECOLOGY JOURNAL, Vol: 24, Pages: 1065-1072, ISSN: 0937-3462

Journal article

Digesu GA, Sadenghi P, Sharma S, Puccini F, Tubaro A, Fernando R, Khullar Vet al., 2013, The importance of cystoscopy and bladder biopsy in women with refractory overactive bladder: the urogynaecologist's point of view?, EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, Vol: 169, Pages: 408-411, ISSN: 0301-2115

Journal article

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