Imperial College London
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ProfessorAndreaCrisanti

Faculty of Natural Sciences, Department of Life Sciences

Professor of Molecular Parasitology
 
 
 
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Contact

 

+44 (0)20 7594 5395a.drcrisanti

 
 
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Assistant

 

Mrs Lucy Collyns +44 (0)20 7594 5395

 
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Location

 

549Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Su:2020:10.1101/2020.09.06.284679,
author = {Su, MP and Georgiades, M and Bagi, J and Kyrou, K and Crisanti, A and Albert, JT},
doi = {10.1101/2020.09.06.284679},
title = {Assessing the acoustic behaviour of<i>Anopheles gambiae</i>s.l.<i>dsxF</i>mutants: Implications for Vector Control},
url = {http://dx.doi.org/10.1101/2020.09.06.284679},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The release of genetically modified mosquitoes which use gene-drive mechanisms to suppress reproduction in natural populations of<jats:italic>Anopheles</jats:italic>mosquitoes is one of the scientifically most promising methods for malaria transmission control. However, many scientific, regulatory and ethical questions remain before transgenic mosquitoes can be utilised in the field. Mutations which reduce an individual’s reproductive success are likely to create strong selective pressures to evolve resistance. It is thus crucial that the targeted population collapses as rapidly and as completely as possible to reduce the available time for the emergence of drive-resistant mutations. At a behavioural level, this means that the gene-drive carrying mutants should be at least as (and ideally more) sexually attractive than the wildtype population they compete against. A key element in the copulatory negotiations of<jats:italic>Anopheles</jats:italic>mosquitoes is their acoustic courtship. We therefore analysed sound emissions and acoustic preference in a<jats:italic>doublesex</jats:italic>mutant previously used to successfully collapse caged colonies of<jats:italic>Anopheles gambiae s</jats:italic>.<jats:italic>l</jats:italic>..</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>The flight tones produced by the beating of their wings form the signals for acoustic mating communication in<jats:italic>Anopheles</jats:italic>species. We assessed the acoustic impact of the disruption of a female-specific isoform of the<jats:italic>doublesex</jats:italic>gene (<jats:italic>dsxF</jats:italic>) on the wing beat frequency (WBF; measured as<jats:italic>flight tone</jats:italic>) of both males (X
AU  - Su,MP
AU  - Georgiades,M
AU  - Bagi,J
AU  - Kyrou,K
AU  - Crisanti,A
AU  - Albert,JT
DO  - 10.1101/2020.09.06.284679
PY  - 2020///
TI  - Assessing the acoustic behaviour of<i>Anopheles gambiae</i>s.l.<i>dsxF</i>mutants: Implications for Vector Control
UR  - http://dx.doi.org/10.1101/2020.09.06.284679
ER  -
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