Imperial College London
Dr Aarif O Eifan

Dr Aarif O Eifan

Faculty of Medicine, National Heart & Lung Institute

Clinical Research Fellow
 
 
 
//

Contact

 

+44 (0)20 7594 3164a.eifan Website

 
 
//

Location

 

Royal BromptonRoyal Brompton Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Eifan:2015:10.1164/rccm.201502-0339OC,
author = {Eifan, AO and Orban, NT and Jacobson, MR and Durham, SR},
doi = {10.1164/rccm.201502-0339OC},
journal = {American Journal of Respiratory and Critical Care Medicine},
pages = {1431--1439},
title = {Severe Persistent Allergic Rhinitis Inflammation but No Histologic Features of Structural Upper Airway Remodeling},
url = {http://dx.doi.org/10.1164/rccm.201502-0339OC},
volume = {192},
year = {2015}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Rationale: Increases in airway smooth muscle, extracellular matrix, and vascularity are prominent features of airway remodeling in asthma, whereas the extent of such remodeling in patients with persistent allergic rhinitis (PAR) is unknown.Objectives: To test the hypothesis that upper airway remodeling is a feature of PAR.Methods: Total nasal symptoms scores, nasal biopsies, and Th1 and Th2 cytokines from nasal lavage were assessed in subjects with severe PAR (n = 46) and healthy control subjects (n = 19). Angiolymphangiogenesis was examined using immunohistochemistry staining against CD31 (vascular endothelial cells), vascular endothelial growth factor-A, and D2-40 (lymphatic endothelial cells). Collagen and extracellular matrix proteins, such as heat shock protein-47 (markers of collagen synthesis), matrix metalloproteinase-9, and tissue inhibitor metalloproteinase-1, and α-smooth muscle actin (myofibroblasts) were evaluated as markers of activation of upper airway remodeling using image analysis, together with reticular basement membrane thickness, mucus gland area, collagen area, and submucosal effector inflammatory cells.Measurements and Main Results: Total nasal symptoms scores, visual analog scale, and total quality of life were significantly higher in PAR compared with healthy control subjects (P < 0.0001). Nasal lavage cytokine levels of IL-4 (P < 0.01), IL-5, and IL-13 (P < 0.001, respectively) were significantly higher in PAR compared with healthy control subjects. In addition there was an increase in submucosal eosinophils (P = 0.06). No statistical difference in terms of angiogenesis, lymphangiogenesis, deposition of extracellular matrix, collagen markers, reticular basement membrane thickness, or glandular percentage area was observed between PAR and healthy control subjects.Conclusions: Our data suggest that tissue remodeling is not a feature of PAR and
AU  - Eifan,AO
AU  - Orban,NT
AU  - Jacobson,MR
AU  - Durham,SR
DO  - 10.1164/rccm.201502-0339OC
EP  - 1439
PY  - 2015///
SN  - 1535-4970
SP  - 1431
TI  - Severe Persistent Allergic Rhinitis Inflammation but No Histologic Features of Structural Upper Airway Remodeling
T2  - American Journal of Respiratory and Critical Care Medicine
UR  - http://dx.doi.org/10.1164/rccm.201502-0339OC
UR  - http://hdl.handle.net/10044/1/29713
VL  - 192
ER  -
Download