Imperial College London
Dr Aarif O Eifan

Dr Aarif O Eifan

Faculty of Medicine, National Heart & Lung Institute

Clinical Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 3164a.eifan Website

 
 
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Location

 

Royal BromptonRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Eifan:2016:10.1111/cea.12780,
author = {Eifan, AO and Durham, SR},
doi = {10.1111/cea.12780},
journal = {Clinical and Experimental Allergy},
pages = {1139--1151},
title = {Pathogenesis of Rhinitis},
url = {http://dx.doi.org/10.1111/cea.12780},
volume = {46},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Rhinitis is a heterogeneous condition that has been associated with inflammatory responses asin allergic rhinitis but can also occur in the absence of inflammation such as in so-called‘idiopathic’ (previously ‘vasomotor’) rhinitis. Allergic rhinitis affects approximately 1 in 4 ofthe population of westernised countries and is characterized by typical symptoms of nasalitching, sneezing, watery discharge and congestion. The intention of this review is toillustrate key concepts of the pathogenesis of rhinitis. Imbalance in innate and adaptiveimmunity together with environmental factors is likely to play major roles. In allergic rhinitis,initial allergen exposure and sensitization involves antigen presenting cells, T and Blymphocytes and results in the generation of allergen-specific T cells and allergen specificIgE antibodies. On re-exposure to relevant allergens crosslinking of IgE on mast cells resultsin the release of mediators of hypersensitivity such as histamine and immediate nasalsymptoms. Within hours, there is an infiltration by inflammatory cells, particularly Th2 Tlymphocytes, eosinophils and basophils into nasal mucosal tissue that results in the late-phaseallergic response. Evidence for nasal priming and whether or not remodelling may be afeature of allergic rhinitis will be reviewed. The occurrence of so-called ‘local’ allergicrhinitis in the absence of systemic IgE will be discussed. Non-allergic (non-IgE mediated)rhinitis will be considered in the context of inflammatory and non-inflammatory disorders.
AU  - Eifan,AO
AU  - Durham,SR
DO  - 10.1111/cea.12780
EP  - 1151
PY  - 2016///
SN  - 1365-2222
SP  - 1139
TI  - Pathogenesis of Rhinitis
T2  - Clinical and Experimental Allergy
UR  - http://dx.doi.org/10.1111/cea.12780
UR  - http://hdl.handle.net/10044/1/37061
VL  - 46
ER  -
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