Summary
Ana Eulalio joined the Department of Life Sciences, Imperial College London, in January 2023. Previously, she established her independent research group at the Institute for Molecular Infection Biology (IMIB), University of Würzburg (Germany) in 2012, and moved to the Center for Neuroscience and Cell Biology (CNC), University of Coimbra (Portugal) in 2017.
Research Interests
Our research focuses on exploring various aspects of host-bacterial pathogen interactions, including the role of microRNAs and the impact of bacterial intracellular lifestyles on pathogenesis.
In the last years, we have identified and characterized novel molecular players and cellular processes governing the complex interaction between host cells and bacterial pathogens (e.g. Salmonella Typhimurium, Shigella flexneri). By profiling a large collection of Staphylococcus aureus clinical isolates, we have recently demonstrated the pervasiveness and diversity of S. aureus intracellular lifestyles, with potential implications for pathogenesis and antibiotic treatment.
Our research approach combines unbiased, genome-wide systems biology approaches, including RNA-sequencing and high-throughput functional screenings, with molecular and cellular biology approaches.
Selected Publications
Journal Articles
Lisowski C, Dias J, Costa S, et al., 2022, Dysregulated endolysosomal trafficking in cells arrested in the G1 phase of the host cell cycle impairs Salmonella vacuolar replication, Autophagy, Vol:18, ISSN:1554-8635, Pages:1785-1800
Rodrigues Lopes I, Alcantara LM, Silva RJ, et al., 2022, Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature, Nature Communications, Vol:13, ISSN:2041-1723
Aguilar C, Costa S, Maudet C, et al., 2021, Reprogramming of microRNA expression via E2F1 downregulation promotes Salmonella infection both in infected and bystander cells, Nature Communications, Vol:12, ISSN:2041-1723
Aguilar C, Cruz AR, Rodrigues Lopes I, et al., 2020, Functional screenings reveal different requirements for host microRNAs in Salmonella and Shigella infection, Nat Microbiol, Vol:5, ISSN:2058-5276, Pages:192-205