Imperial College London
Portrait Picture

Professor Aldo Faisal

Faculty of Engineering, Department of Bioengineering

Professor of AI & Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 6373a.faisal Website

 
 
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Assistant

 

Miss Teresa Ng +44 (0)20 7594 8300

 
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Location

 

4.08Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gallego-Delgado:2020:10.1371/journal.pbio.3001008,
author = {Gallego-Delgado, P and James, R and Browne, E and Meng, J and Umashankar, S and Tan, L and Picon, C and Mazarakis, ND and Faisal, AA and Howell, OW and Reynolds, R},
doi = {10.1371/journal.pbio.3001008},
journal = {PLoS Biology},
pages = {1--36},
title = {Neuroinflammation in the normal-appearing white matter (NAWM) of the multiple sclerosis brain causes abnormalities at the nodes of Ranvier.},
url = {http://dx.doi.org/10.1371/journal.pbio.3001008},
volume = {18},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Changes to the structure of nodes of Ranvier in the normal-appearing white matter (NAWM) of multiple sclerosis (MS) brains are associated with chronic inflammation. We show that the paranodal domains in MS NAWM are longer on average than control, with Kv1.2 channels dislocated into the paranode. These pathological features are reproduced in a model of chronic meningeal inflammation generated by the injection of lentiviral vectors for the lymphotoxin-α (LTα) and interferon-γ (IFNγ) genes. We show that tumour necrosis factor (TNF), IFNγ, and glutamate can provoke paranodal elongation in cerebellar slice cultures, which could be reversed by an N-methyl-D-aspartate (NMDA) receptor blocker. When these changes were inserted into a computational model to simulate axonal conduction, a rapid decrease in velocity was observed, reaching conduction failure in small diameter axons. We suggest that glial cells activated by pro-inflammatory cytokines can produce high levels of glutamate, which triggers paranodal pathology, contributing to axonal damage and conduction deficits.
AU  - Gallego-Delgado,P
AU  - James,R
AU  - Browne,E
AU  - Meng,J
AU  - Umashankar,S
AU  - Tan,L
AU  - Picon,C
AU  - Mazarakis,ND
AU  - Faisal,AA
AU  - Howell,OW
AU  - Reynolds,R
DO  - 10.1371/journal.pbio.3001008
EP  - 36
PY  - 2020///
SN  - 1544-9173
SP  - 1
TI  - Neuroinflammation in the normal-appearing white matter (NAWM) of the multiple sclerosis brain causes abnormalities at the nodes of Ranvier.
T2  - PLoS Biology
UR  - http://dx.doi.org/10.1371/journal.pbio.3001008
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33315860
UR  - https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001008
UR  - http://hdl.handle.net/10044/1/85230
VL  - 18
ER  -
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