Publications
166 results found
Navaratnam AMD, Mutumba-Nakalembe MJ, Stothard JR, et al., 2012, Notes on the use of urine-CCA dipsticks for detection of intestinal schistosomiasis in preschool children, TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, Vol: 106, Pages: 619-622, ISSN: 0035-9203
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- Citations: 17
Navaratnam AMD, Sousa-Figueiredo JC, Stothard JR, et al., 2012, Efficacy of praziquantel syrup versus crushed praziquantel tablets in the treatment of intestinal schistosomiasis in Ugandan preschool children, with observation on compliance and safety, TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, Vol: 106, Pages: 400-407, ISSN: 0035-9203
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- Citations: 28
Landoure A, Dembele R, Goita S, et al., 2012, Significantly Reduced Intensity of Infection but Persistent Prevalence of Schistosomiasis in a Highly Endemic Region in Mali after Repeated Treatment, PLOS NEGLECTED TROPICAL DISEASES, Vol: 6, ISSN: 1935-2735
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- Citations: 33
Robinson O, Toledano MB, Goldin R, et al., 2012, HIRMI VALLEY LIVER DISEASE: A TALE OF TWO TOXINS, 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL), Publisher: ELSEVIER SCIENCE BV, Pages: S33-S34, ISSN: 0168-8278
Molyneux D, Malecela M, Savioli L, et al., 2012, Will increased funding for neglected tropical diseases really make poverty history? reply, LANCET, Vol: 379, Pages: 1098-1100, ISSN: 0140-6736
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- Citations: 6
Fenwick A, 2012, The global burden of neglected tropical diseases, PUBLIC HEALTH, Vol: 126, Pages: 233-236, ISSN: 0033-3506
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- Citations: 119
Hotez PJ, Savioli L, Fenwick A, 2012, Neglected Tropical Diseases of the Middle East and North Africa: Review of Their Prevalence, Distribution, and Opportunities for Control, PLOS NEGLECTED TROPICAL DISEASES, Vol: 6, ISSN: 1935-2735
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- Citations: 209
Solomon AW, Engels D, Bailey RL, et al., 2012, A Diagnostics Platform for the Integrated Mapping, Monitoring and Surveillance of Neglected Tropical Diseases: Rationale and Target Product Profiles, PLoS Neglected Tropical Diseases
Kabatereine NB, Standley CJ, Sousa-Figueiredo JC, et al., 2011, Integrated prevalence mapping of schistosomiasis, soil-transmitted helminthiasis and malaria in lakeside and island communities in Lake Victoria, Uganda, PARASITES & VECTORS, Vol: 4, ISSN: 1756-3305
Oshish A, AlKohlani A, Hamed A, et al., 2011, Towards nationwide control of schistosomiasis in Yemen: a pilot project to expand treatment to the whole community, TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, Vol: 105, Pages: 617-627, ISSN: 0035-9203
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- Citations: 20
Stothard JR, Sousa-Figueiredo JC, Betson M, et al., 2011, Closing the praziquantel treatment gap: new steps in epidemiological monitoring and control of schistosomiasis in African infants and preschool-aged children, PARASITOLOGY, Vol: 138, Pages: 1593-1606, ISSN: 0031-1820
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- Citations: 76
Lamberton P, Hogan S, Kabatereine N, et al., 2011, Schistosome miracidial behaviour: <i>in vitro</i> and <i>in vivo</i> praziquantel selective pressures, Publisher: WILEY-BLACKWELL, Pages: 70-70, ISSN: 1360-2276
Fenwick A, 2011, Raising the international profile of schistosomiasis, TROPICAL MEDICINE & INTERNATIONAL HEALTH, Vol: 16, Pages: 23-24, ISSN: 1360-2276
Green HK, Sousa-Figueiredo JC, Basanez M-G, et al., 2011, Anaemia in Ugandan preschool-aged children: the relative contribution of intestinal parasites and malaria, PARASITOLOGY, Vol: 138, Pages: 1534-1545, ISSN: 0031-1820
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- Citations: 30
Leslie J, Garba A, Oliva EB, et al., 2011, Schistosomiais and Soil-Transmitted Helminth Control in Niger: Cost Effectiveness of School Based and Community Distributed Mass Drug Administration, PLOS NEGLECTED TROPICAL DISEASES, Vol: 5, ISSN: 1935-2735
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- Citations: 46
Ndayishimiye O, Willems J, Manirakiza E, et al., 2011, Population-Based Survey of Active Trachoma in 11 Districts of Burundi, OPHTHALMIC EPIDEMIOLOGY, Vol: 18, Pages: 146-149, ISSN: 0928-6586
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- Citations: 7
Koukounari A, Toure S, Donnelly CA, et al., 2011, Integrated monitoring and evaluation and environmental risk factors for urogenital schistosomiasis and active trachoma in Burkina Faso before preventative chemotherapy using sentinel sites, BMC INFECTIOUS DISEASES, Vol: 11, ISSN: 1471-2334
Background: Over 1 billion of the world’s poorest inhabitants are afflicted by neglected tropical diseases (NTDs).Integrated control programmes aimed at tackling these debilitating NTDs have been recently initiated, mainlyusing preventative chemotherapy. Monitoring and evaluation (M&E) of these integrated programs presentsparticular challenges over and above those required for single disease vertical programmes. We used baseline datafrom the National NTD Control Programme in Burkina Faso in order to assess the feasibility of an integrated surveydesign, as well as to elucidate the contribution of environmental variables to the risk of either Schistosomahaematobium, trachoma, or both among school-aged children.Methods: S. haematobium infection was diagnosed by detecting eggs in urine. A trachoma case was defined bythe presence of Trachomatous inflammation-Follicular (TF) and/or Trachomatous inflammation-Intense (TI) in eithereye. Baseline data collected from 3,324 children aged 7-11 years in 21 sentinel sites across 11 regions of BurkinaFaso were analyzed using simple and multivariable hierarchical binomial logistic regression models fitted byMarkov Chain Monte Carlo estimation methods. Probabilities of the risk of belonging to each infection/diseasecategory were estimated as a function of age, gender (individual level), and environmental variables (at sentinelsite level, interpolated from national meteorological stations).Results: Overall prevalence at the sentinel sites was 11.79% (95% CI: 10.70-12.89) for S. haematobium; 13.30%(12.14-14.45) for trachoma and 0.84% (0.53-1.15) for co-infections. The only significant predictor of S. haematobiuminfection was altitude. There were significant negative associations between the prevalence of active trachomasigns and minimum temperature, and air pressure. Conditional upon these predictors, these data are consistentwith the two pathogens being independent.Conclusions: Urogenital schistosomiasis and trachoma constit
Magalhaes RJS, Biritwum N-K, Gyapong JO, et al., 2011, Mapping Helminth Co-Infection and Co-Intensity: Geostatistical Prediction in Ghana, PLOS NEGLECTED TROPICAL DISEASES, Vol: 5, ISSN: 1935-2735
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- Citations: 63
Fenwick A, Savioli L, 2011, Untitled, LANCET INFECTIOUS DISEASES, Vol: 11, Pages: 346-346, ISSN: 1473-3099
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- Citations: 10
Fenwick A, Savioli L, 2011, Schistosomiasis elimination., Lancet Infect Dis, Vol: 11
Lamberton PHL, Hogan SC, Kabatereine NB, et al., 2010, <i>In</i> <i>Vitro</i> Praziquantel Test Capable of Detecting Reduced <i>In Vivo</i> Efficacy in <i>Schistosoma mansoni</i> Human Infections, AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, Vol: 83, Pages: 1340-1347, ISSN: 0002-9637
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- Citations: 29
French MD, Churcher TS, Gambhir M, et al., 2010, Observed Reductions in <i>Schistosoma mansoni</i> Transmission from Large-Scale Administration of Praziquantel in Uganda: A Mathematical Modelling Study, PLOS NEGLECTED TROPICAL DISEASES, Vol: 4, ISSN: 1935-2735
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- Citations: 62
Norton AJ, Gower CM, Lamberton PHL, et al., 2010, Genetic Consequences of Mass Human Chemotherapy for <i>Schistosoma mansoni</i>: Population Structure Pre- and Post-Praziquantel Treatment in Tanzania, AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, Vol: 83, Pages: 951-957, ISSN: 0002-9637
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- Citations: 60
Garba A, Barkire N, Djibo A, et al., 2010, Schistosomiasis in infants and preschool-aged children: Infection in a single <i>Schistosoma haematobium</i> and a mixed <i>S</i>. <i>haematobium</i>-<i>S</i>. <i>mansoni</i> foci of Niger, ACTA TROPICA, Vol: 115, Pages: 212-219, ISSN: 0001-706X
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- Citations: 81
Hotez PJ, Engels D, Fenwick A, et al., 2010, Africa is desperate for praziquantel, LANCET, Vol: 376, Pages: 496-498, ISSN: 0140-6736
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- Citations: 49
Koukounari A, Donnelly CA, Sacko M, et al., 2010, The impact of single versus mixed schistosome species infections on liver, spleen and bladder morbidity within Malian children pre- and post-praziquantel treatment, BMC Infectious Diseases, Vol: 10, ISSN: 1471-2334
Background: In the developing world co-infections and polyparasitism within humans appear to be the rule rather than the exception, be it any combination of inter-specific and/or inter- and intra-Genera mixed infections. Mixed infections might generate synergistic or antagonistic interactions and thereby clinically affect individuals and/or impact parasite epidemiology.Methods: The current study uniquely assesses both Schistosoma mansoni- and Schistosoma haematobium-related morbidity of the liver and the bladder as assessed by ultrasound as well as spleen and liver morbidity through clinical exams. The impact of praziquantel (PZQ) treatment on such potential inter-specific schistosome interactions and resulting morbidity using uniquely detailed longitudinal data (pre- and one year post-PZQ treatment) arising from the National Schistosomiasis Control Program in three areas of Mali: Ségou, Koulikoro and Bamako, is also evaluated. At baseline, data were collected from up to 2196 children (aged 7-14 years), 844 of which were infected with S. haematobium only, 124 with S. mansoni only and 477 with both. Follow-up data were collected from up to 1265 children.Results|: Results suggested lower liver morbidity in mixed compared to single S. mansoni infections and higher bladder morbidity in mixed compared to single S. haematobium infections. Single S. haematobium or S. mansoni infections were also associated with liver and spleen morbidity whilst only single S. haematobium infections were associated with bladder morbidity in these children (light S. haematobium infection OR: 4.3, p < 0.001 and heavy S. haematobium infection OR: 19, p < 0.001). PZQ treatment contributed to the regression of some of the forms of such morbidities.Conclusions: Whilst the precise biological mechanisms for these observations remain to be ascertained, the results illustrate the importance of considering mixed species infections in any analyses of parasite-induced morbidity, including t
Standley CJ, Adriko M, Arinaitwe M, et al., 2010, Epidemiology and control of intestinal schistosomiasis on the Sesse Islands, Uganda: integrating malacology and parasitology to tailor local treatment recommendations, PARASITES & VECTORS, Vol: 3, ISSN: 1756-3305
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- Citations: 30
Fenwick A, Zhang Y, Stoever K, 2010, Control of the Neglected Tropical Diseases in sub-Saharan Africa: the unmet needs (vol 1, pg 61, 2009), INTERNATIONAL HEALTH, Vol: 2, Pages: 75-75, ISSN: 1876-3413
Clements ACA, Deville M-A, Ndayishimiye O, et al., 2010, Spatial co-distribution of neglected tropical diseases in the East African Great Lakes region: revisiting the justification for integrated control, TROPICAL MEDICINE & INTERNATIONAL HEALTH, Vol: 15, Pages: 198-207, ISSN: 1360-2276
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- Citations: 75
Clements ACA, Firth S, Dembele R, et al., 2009, Use of Bayesian geostatistical prediction to estimate local variations in <i>Schistosoma haematobium</i> infection in western Africa, BULLETIN OF THE WORLD HEALTH ORGANIZATION, Vol: 87, Pages: 921-929, ISSN: 0042-9686
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- Citations: 47
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