Imperial College London
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ProfessorAlainFilloux

Faculty of Natural Sciences, Department of Life Sciences

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 9651a.filloux Website CV

 
 
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Location

 

1.47Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{McCarthy:2019:10.1111/mmi.14279,
author = {McCarthy, RR and Yu, M and Eilers, K and Wang, Y-C and Lai, E-M and Filloux, A},
doi = {10.1111/mmi.14279},
journal = {Molecular Microbiology},
pages = {632--648},
title = {Cyclic di-GMP inactivates T6SS and T4SS activity in Agrobacterium tumefaciens},
url = {http://dx.doi.org/10.1111/mmi.14279},
volume = {112},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The Type VI secretion system (T6SS) is a bacterial nanomachine that delivers effector proteins into prokaryotic and eukaryotic preys. This secretion system has emerged as a key player in regulating the microbial diversity in a population. In the plant pathogen Agrobacterium tumefaciens, the signalling cascades regulating the activity of this secretion system are poorly understood. Here, we outline how the universal eubacterial second messenger cyclic di-GMP impacts the production of T6SS toxins and T6SS structural components. We demonstrate that this has a significant impact on the ability of the phytopathogen to compete with other bacterial species in vitro and in planta. Our results suggest that, as opposed to other bacteria, c-di-GMP turns down the T6SS in A. tumefaciens thus impacting its ability to compete with other bacterial species within the rhizosphere. We also demonstrate that elevated levels of c-di-GMP within the cell decrease the activity of the Type IV secretion system (T4SS) and subsequently the capacity of A. tumefaciens to transform plant cells. We propose that such peculiar control reflects on c-di-GMP being a key second messenger that silences energy-costing systems during early colonization phase and biofilm formation, while low c-di-GMP levels unleash T6SS and T4SS to advance plant colonization.
AU  - McCarthy,RR
AU  - Yu,M
AU  - Eilers,K
AU  - Wang,Y-C
AU  - Lai,E-M
AU  - Filloux,A
DO  - 10.1111/mmi.14279
EP  - 648
PY  - 2019///
SN  - 0950-382X
SP  - 632
TI  - Cyclic di-GMP inactivates T6SS and T4SS activity in Agrobacterium tumefaciens
T2  - Molecular Microbiology
UR  - http://dx.doi.org/10.1111/mmi.14279
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31102484
UR  - https://onlinelibrary.wiley.com/doi/full/10.1111/mmi.14279
UR  - http://hdl.handle.net/10044/1/72390
VL  - 112
ER  -
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