Imperial College London
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ProfessorAlainFilloux

Faculty of Natural Sciences, Department of Life Sciences

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 9651a.filloux Website CV

 
 
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Location

 

1.47Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Valentini:2017:10.1016/j.mib.2017.11.006,
author = {Valentini, M and Gonzalez, D and Mavridou, DAI and Filloux, A},
doi = {10.1016/j.mib.2017.11.006},
journal = {Current Opinion in Microbiology},
pages = {15--20},
title = {Lifestyle transitions and adaptive pathogenesis of Pseudomonas aeruginosa},
url = {http://dx.doi.org/10.1016/j.mib.2017.11.006},
volume = {41},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Pseudomonas aeruginosa acute and chronic infections are of great concern to human health, especially in hospital settings. It is currently assumed that P. aeruginosa has two antagonistic pathogenic strategies that parallel two different lifestyles; free-living cells are predominantly cytotoxic and induce an acute inflammatory reaction, while biofilm-forming communities cause refractory chronic infections. Recent findings suggest that the planktonic-to-sessile transition is a complex, reversible and overall dynamic differentiation process. Here, we examine how the Gac/Rsm regulatory cascade, a key player in this lifestyle switch, endows P. aeruginosa with both a permissive lifecycle in nature and flexible virulence strategy during infection.
AU  - Valentini,M
AU  - Gonzalez,D
AU  - Mavridou,DAI
AU  - Filloux,A
DO  - 10.1016/j.mib.2017.11.006
EP  - 20
PY  - 2017///
SN  - 1369-5274
SP  - 15
TI  - Lifestyle transitions and adaptive pathogenesis of Pseudomonas aeruginosa
T2  - Current Opinion in Microbiology
UR  - http://dx.doi.org/10.1016/j.mib.2017.11.006
UR  - http://hdl.handle.net/10044/1/57221
VL  - 41
ER  -
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