Overview
The ability to manipulate and track neuronal communication is essential to understanding the mechanisms underlying our sensations, perceptions, thoughts, emotions and actions. With a growing toolbox of optical dyes, genetic sensors and actuators, Neuroscience has made science fiction-scale progress toward realizing this important prerequisite for neural circuit reverse engineering. A parallel revolution in photonics research is taking shape to exploit the full potential of photo-molecular tools for brain circuit interrogation. My goal is to engineer bridges between recent optical technology and Neurophysiologists endeavoring to close the loop between theory and experimentation.
Fields of Expertise
Intrinsic imaging (scattering, absorbtion, birefringence)
Functional fluoroscence imaging (voltage, calcium)
Two-photon microscopy
Computer-generated holography
Temporal focusing
Electrophysiology (patch clamp, extracellular)
Computational neuroscience
Optomechanical design and prototyping
Functional image acquisition and analysis software
Training, Professional Experience
2016-present Royal Academy of Engineering Research Fellow
2018-present Lecturer Imperial College London
Dept. Bioengineering
Centre for Neurotechnology
2015 Postdoc Imperial College London
Dept. Bioengineering
Centre for Neurotechnology
Advisor: Simon Schultz, Ph.D.
2013-2014 Postdoc University Paris Descartes
Dept. Neurophotonics
Wavefront Engineering
Advisor: Valentina Emiliani, Ph.D.
2007-2010 M.Phil. Yale University
2007-2012 Ph.D. With Distinction
Neuroscience, Dept. Neurobiology
Advisor: David A. McCormick, Ph.D.
2002-2006 B.S. Washington State University,
Summa cum laude
Neuroscience
Emphasis EE and computation
Advisor: David M. Rector, Ph.D.
Research Support
Integrated Biological Imaging Network Pump-prime
Role: Principal Investigator
9/2020-12/2020
Imaging membrane voltage light fields: new views into the pathophysiology of cancer
EPSRC Capital Award for Early Career Researchers
Role: Principal Investigator
11/2018-5/2020
Instrument for characterizing two-photon absorption and action spectra of red and near-infrared fluorophores and membrane conductance actuators
BBSRC Research Grant BB/R009007/1
Role: Principal Investigator
6/2018-5/2021
Two-photon Light Field with Neuro-active Sensing for Fast Volumetric Neural Microcircuit Readout
Wellcome Seed Award
Role: Principal Investigator
10/2016 - 9/2018
Holographic Induction of Neural Circuit Plasticity
Royal Academy of Engineering Research Fellowship
Role: Research Fellow
1/2016 - 12/2020
Holographic Light Shaping for Reverse
Engineering Neural Circuit Learning
Imperial College London Junior Research Fellowship
Declined
Two-photon Computer-Generated Holography for
Investigation of Dendritic Information Processing
U01 NS090501-01 (US NIH, B.R.A.I.N.)
Role: Co-Investigator
1/2015 - 12/2017
Three Dimensional Computer-Generated Holography
For Neural Circuit Reverse Engineering
NSF Postdoctoral International Research Fellowship
Role: Post-Doctoral Fellow
1/2013 - 12/2014
Scanless Two-Photon Voltage Imaging of Live Neuron
Activity with Holographic Wavefront Shaping
Whitaker Foundation Post-doctoral Fellowship
Awarded 2012 (declined)
NRSA F31 NS 070368-01 (NIH/NINDS)
Role: Principal Investigator
9/2010 - 5/2012
Optical Imaging of Information Processing in CNS Axons
NSF Graduate Research Fellowship
Role: Pre-Doctoral Fellow
9/2007 - 8/2010