Summary
BSc(Hons), MSc, PhD, MBBS, FRCS (Gen Surg), MRCSEd, FRSB, FESSR, DipMedTox
Adam is currently an Honorary Clinical Lecturer working in the Department of Surgery & Cancer at Hammersmith Hospital, Imperial College London. He completed his General & HPB Surgical training on the London Deanery (South-West Thames) rotation, and is a Consultant General & HPB Surgeon at the Royal Surrey County Hospital, Guildford, Surrey.
Adam undertook his undergraduate medical training at Charing Cross Hospital (ICSM) from 1997-2003 and achieved a First Class intercalated BSc(Hons) in Pharmacology and Toxicology at Imperial College.
He completed his Basic Surgical Training in Surrey and then spent a year doing Renal Transplant and Vascular Access Surgery at St. Georges Hospital, Tooting (2007-2008). At the same time he completed a MSc with Merit in Surgical Practice.
He joined the HPB Surgical Unit at the Hammersmith Hospital in 2009 as a Clinical Research Fellow to develop the TVoSS (True Value of Surgical Services) clinical coding project and undertake a period of basic science and translational research. He was awarded his PhD in Molecular Oncology in 2014, working under the supervision of Dr Leandro Castellano, Professor Justin Stebbing and Professor Long Jiao.
Adam now runs a lab group with Dr Jonathan Krell investigating Molecular Oncogenetics. His research aims are to discover crucial microRNAs involved in the development and progression of Pancreatic Ductal Adenocarcinoma (PDAC), as well as elucidating their mechanistic roles. He is also investigating the role of microRNAs as biomarkers for improving pre-operative diagnosis and stratification, and also as possible targets for therapy.
Adam won the Moynihan Prize in May 2017 for his research, which is the most prestigious scientific award given by the Association of Surgeons of Great Britain & Ireland (ASGBI). Adam was then elected as a Fellow of the Royal Society of Biology (FRSB) in July 2017 for his contributions to small RNA and cancer biology.
Adam was awarded the distinguished Hunterian Professorship by the Royal College of Surgeons of England in May 2018, and was elected as Fellow of the European Society of Surgical Research (FESSR) in June 2018.
Click here for Adam's Expertscape profile.
Adam is funded by grants from:
Selected Publications
Journal Articles
Malczewska A, Frampton AE, Mato Prado M, et al., 2021, Circulating microRNAs in small-bowel neuroendocrine tumors: a potential tool for diagnosis and assessment of effectiveness of surgical resection, Annals of Surgery, Vol:274, ISSN:0003-4932, Pages:e1-e9
Ottaviani S, Stebbing J, Frampton AE, et al., 2018, TGF-beta induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression, Nature Communications, Vol:9, ISSN:2041-1723
Frampton AE, Mato Prado M, Lopez Jimenez ME, et al., 2018, Glypican-1 is enriched in circulating-exosomes in pancreatic cancer and correlates with tumor burden, Oncotarget, Vol:9, ISSN:1949-2553, Pages:19006-19013
Frampton AE, Krell J, Mato Prado M, et al., 2016, Prospective validation of microRNA signatures for detecting pancreatic malignant transformation in endoscopic-ultrasound guided fine-needle aspiration biopsies, Oncotarget, Vol:7, ISSN:1949-2553
Krell J, Stebbing J, Carissimi C, et al., 2016, TP53 regulates miRNA association with AGO2 to remodel the miRNA-mRNA interaction network, Genome Research, Vol:26, ISSN:1088-9051, Pages:331-341
Krell J, Stebbing J, Frampton AE, et al., 2015, The role of TP53 in miRNA loading onto AGO2 and in remodelling the miRNA-mRNA interaction network, The Lancet, Vol:385, ISSN:0140-6736, Pages:15-15
Frampton AE, Castellano L, Colombo T, et al., 2015, Integrated molecular analysis to investigate the role of microRNAs in pancreatic tumour growth and progression, The Lancet, Vol:385, ISSN:0140-6736, Pages:37-37
Frampton AE, Castellano L, Colombo T, et al., 2014, MicroRNAs Cooperatively Inhibit a Network of Tumor Suppressor Genes to Promote Pancreatic Tumor Growth and Progression, Gastroenterology, Vol:146, ISSN:0016-5085, Pages:268-+
Conference
Frampton AE, Krel J, Gall TM, et al., 2015, Prospective Validation of Microrna Signatures for Detecting Pancreatic Malignant Transformation in Endoscopic-Ultrasound Guided Fine-Needle Aspiration Biopsies, International Surgical Congress of the Association-of-Surgeons-of-Great-Britain-and-Ireland (ASGBI), WILEY-BLACKWELL, Pages:7-7, ISSN:0007-1323
Zabron A, Frampton A, Krell J, et al., 2013, SPECIFIC MICRORNA MARKERS ARE IDENTIFIED IN BILE IN PANCREATIC DUCTAL ADENOCARCINOMA, Annual General Meeting of the British-Society-of-Gastroenterology, BMJ PUBLISHING GROUP, Pages:A17-A17, ISSN:0017-5749