Publications
199 results found
Xu Y, Zhang H, Lit LC, et al., 2014, The Kinase LMTK3 Promotes Invasion in Breast Cancer Through GRB2-Mediated Induction of Integrin β<sub>1</sub>, SCIENCE SIGNALING, Vol: 7, ISSN: 1945-0877
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- Citations: 31
Krell J, Frampton AE, Mirnezami R, et al., 2014, Growth Arrest-Specific Transcript 5 Associated snoRNA Levels Are Related to p53 Expression and DNA Damage in Colorectal Cancer, PLOS One, Vol: 9, ISSN: 1932-6203
Background: The growth arrest-specific transcript 5 gene (GAS5) encodes a long noncoding RNA (lncRNA) and hosts anumber of small nucleolar RNAs (snoRNAs) that have recently been implicated in multiple cellular processes and cancer.Here, we investigate the relationship between DNA damage, p53, and the GAS5 snoRNAs to gain further insight into thepotential role of this locus in cell survival and oncogenesis both in vivo and in vitro.Methods: We used quantitative techniques to analyse the effect of DNA damage on GAS5 snoRNA expression and to assessthe relationship between p53 and the GAS5 snoRNAs in cancer cell lines and in normal, pre-malignant, and malignanthuman colorectal tissue and used biological techniques to suggest potential roles for these snoRNAs in the DNA damageresponse.Results: GAS5-derived snoRNA expression was induced by DNA damage in a p53-dependent manner in colorectal cancercell lines and their levels were not affected by DICER. Furthermore, p53 levels strongly correlated with GAS5-derived snoRNAexpression in colorectal tissue.Conclusions: In aggregate, these data suggest that the GAS5-derived snoRNAs are under control of p53 and that they havean important role in mediating the p53 response to DNA damage, which may not relate to their function in the ribosome.We suggest that these snoRNAs are not processed by DICER to form smaller snoRNA-derived RNAs with microRNA (miRNA)-like functions, but their precise role requires further evaluation. Furthermore, since GAS5 host snoRNAs are often used asendogenous controls in qPCR quantifications we show that their use as housekeeping genes in DNA damage experimentscan lead to inaccurate results.
Gall TMH, Basyouny M, Frampton AE, et al., 2014, Neoadjuvant chemotherapy and primary-first approach for rectal cancer with synchronous liver metastases, COLORECTAL DISEASE, Vol: 16, Pages: O197-O205, ISSN: 1462-8910
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- Citations: 9
Gall TMH, Jacob J, Frampton AE, et al., 2014, Reduced dissemination of circulating tumor cells with no-touch isolation surgical technique in patients with pancreatic cancer, JAMA Surgery, Vol: 149, Pages: 482-485, ISSN: 2168-6254
Roca-Alonso L, Castellano L, Mills A, et al., 2014, Myocardial miR-30 down-regulation triggered by doxorubicin drives alterations in the beta-adrenergic pathway and enhances apoptosis, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 16, Pages: 115-115, ISSN: 1388-9842
Frampton AE, Giovannetti E, Jamieson NB, et al., 2014, A microRNA meta-signature for pancreatic ductal adenocarcinoma, EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, Vol: 14, Pages: 267-271, ISSN: 1473-7159
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- Citations: 25
Gall TMH, Thompson Z, Dinneen EP, et al., 2014, Surgical techniques for improving outcomes in pancreatic ductal adenocarcinoma, EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, Vol: 8, Pages: 241-246, ISSN: 1747-4124
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- Citations: 6
Frampton AE, Castellano L, Colombo T, et al., 2014, MicroRNAs Cooperatively Inhibit a Network of Tumor Suppressor Genes to Promote Pancreatic Tumor Growth and Progression, GASTROENTEROLOGY, Vol: 146, Pages: 268-+, ISSN: 0016-5085
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- Citations: 132
Hossain MA, Frampton AE, Bagul A, 2014, Challenges facing in vivo tracking of mesenchymal stem cells used for tissue regeneration., Expert Rev Med Devices, Vol: 11, Pages: 9-13
Bone marrow-derived mesenchymal stem cells (MSCs) are increasingly being investigated in the field of regenerative medicine. In vivo monitoring of MSCs can be performed with MRI, which is a non-invasive, non-toxic and clinically acceptable modality. In order to track these MSCs, cells must be labeled with detectable magnetic nanoparticles. However, they 'leak' from labeled cells, limiting their surveillance to a 3-week period. Li et al. developed a rodent model in order to evaluate MRI monitoring of intramuscularly injected aminopropyltriethoxysilane iron oxide-labeled MSCs. Both in vivo tracking and histological analysis were undertaken. Seeded MSCs demonstrated increased MRI signal in the labeled test group over 3 weeks compared with the unlabeled controls. Histological Prussian blue staining of posttermination tissues confirmed these findings. The authors conclude that successful labeling of MSCs is possible with aminopropyltriethoxysilane - magnetic nanoparticles and that these cells can be monitored in vivo. They offer this form of labeling as an alternative to more common dextran-coated magnetic nanoparticles.
Maftouh M, Avan A, Funel N, et al., 2014, MIR-211 MODULATES GEMCITABINE ACTIVITY THROUGH DOWNREGULATION OF RIBONUCLEOTIDE REDUCTASE AND INHIBITS THE INVASIVE BEHAVIOR OF PANCREATIC CANCER CELLS, 15th International Symposium on Purine and Pyrimidine Metabolism in Man, Publisher: TAYLOR & FRANCIS INC, Pages: 384-393, ISSN: 1525-7770
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- Citations: 54
Gall TMH, Frampton AE, Krell J, et al., 2013, Optimizing Unresectable Colorectal Liver Metastases for Surgery-No Limits, Any Benefits?, JOURNAL OF GASTROINTESTINAL SURGERY, Vol: 17, Pages: 2185-2187, ISSN: 1091-255X
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- Citations: 2
Krell D, Mulholland P, Frampton AE, et al., 2013, IDH mutations in tumorigenesis and their potential role as novel therapeutic targets, FUTURE ONCOLOGY, Vol: 9, Pages: 1923-1935, ISSN: 1479-6694
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- Citations: 46
Gall TMH, Frampton AE, Krell J, et al., 2013, Cell-free DNA for the detection of pancreatic, liver and upper gastrointestinal cancers: has progress been made?, FUTURE ONCOLOGY, Vol: 9, Pages: 1861-1869, ISSN: 1479-6694
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- Citations: 5
Gall TMH, Frampton AE, 2013, Gene of the month: E-cadherin (CDH1)., J Clin Pathol, Vol: 66, Pages: 928-932
Gall TMH, Frampton AE, Krell J, et al., 2013, Is the detection of circulating tumor cells in locally advanced pancreatic cancer a useful prognostic marker?, EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, Vol: 13, Pages: 793-796, ISSN: 1473-7159
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- Citations: 10
Pinho FG, Frampton AE, Nunes J, et al., 2013, Downregulation of microRNA-515-5p by the Estrogen Receptor Modulates Sphingosine Kinase 1 and Breast Cancer Cell Proliferation, CANCER RESEARCH, Vol: 73, Pages: 5936-5948, ISSN: 0008-5472
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- Citations: 64
Lawn AM, Frampton AE, Krell J, et al., 2013, Lymph node ratio can further stratify prognosis in subpopulations of breast cancer patients with axillary nodal metastases, FUTURE ONCOLOGY, Vol: 9, Pages: 1425-1431, ISSN: 1479-6694
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- Citations: 4
Frampton AE, Krell J, Kazemier G, et al., 2013, Serum miR-1290 as a Marker of Pancreatic Cancer-Letter, CLINICAL CANCER RESEARCH, Vol: 19, Pages: 5250-5251, ISSN: 1078-0432
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- Citations: 3
Krell J, Frampton AE, Colombo T, et al., 2013, The p53 miRNA interactome and its potential role in the cancer clinic, EPIGENOMICS, Vol: 5, Pages: 417-428, ISSN: 1750-1911
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- Citations: 26
Pai M, Frampton AE, Virk JS, et al., 2013, Preoperative Superselective Mesenteric Angiography and Methylene Blue Injection for Localization of Obscure Gastrointestinal Bleeding, JAMA SURGERY, Vol: 148, Pages: 665-668, ISSN: 2168-6254
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- Citations: 14
Zabron A, Frampton A, Krell J, et al., 2013, SPECIFIC MICRORNA MARKERS ARE IDENTIFIED IN BILE IN PANCREATIC DUCTAL ADENOCARCINOMA, Annual General Meeting of the British-Society-of-Gastroenterology, Publisher: BMJ PUBLISHING GROUP, Pages: A17-A17, ISSN: 0017-5749
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- Citations: 1
Zabron A, Frampton A, Krell J, et al., 2013, BILIARY MICRORNA MARKERS IN BILE AID THE DIAGNOSIS OF CHOLANGIOCARCINOMA AT ERCP, Annual General Meeting of the British-Society-of-Gastroenterology, Publisher: BMJ PUBLISHING GROUP, Pages: A80-A80, ISSN: 0017-5749
Frampton AE, Fletcher CE, Gall TMH, et al., 2013, Circulating peripheral blood mononuclear cells exhibit altered miRNA expression patterns in pancreatic cancer, EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, Vol: 13, Pages: 425-430, ISSN: 1473-7159
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- Citations: 19
Stebbing J, Payne R, Reise J, et al., 2013, The Efficacy of Lapatinib in Metastatic Breast Cancer with HER2 Non-Amplified Primary Tumors and EGFR Positive Circulating Tumor Cells: A Proof-Of-Concept Study, PLOS ONE, Vol: 8, ISSN: 1932-6203
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- Citations: 27
Payne SJL, Krell J, Wilson P, et al., 2013, The efficacy of tacrolimus and sirolimus in heavily pre-treated unresectable thymic malignancies, LUNG CANCER, Vol: 80, Pages: 228-229, ISSN: 0169-5002
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- Citations: 2
Frampton AE, Gall TMH, Giovannetti E, et al., 2013, Distinct miRNA profiles are associated with malignant transformation of pancreatic cystic tumors revealing potential biomarkers for clinical use, EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, Vol: 13, Pages: 325-329, ISSN: 1473-7159
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- Citations: 9
Pellegrino L, Stebbing J, Braga VM, et al., 2013, miR-23b regulates cytoskeletal remodeling, motility and metastasis by directly targeting multiple transcripts, Nucleic Acids Research, Vol: 41, Pages: 5400-5412, ISSN: 1362-4962
Uncontrolled cell proliferation and cytoskeletal remodeling are responsible for tumor development and ultimately metastasis. A number of studies have implicated microRNAs in the regulation of cancer cell invasion and migration. Here, we show that miR-23b regulates focal adhesion, cell spreading, cell-cell junctions and the formation of lamellipodia in breast cancer (BC), implicating a central role for it in cytoskeletal dynamics. Inhibition of miR-23b, using a specific sponge construct, leads to an increase of cell migration and metastatic spread in vivo, indicating it as a metastatic suppressor microRNA. Clinically, low miR-23b expression correlates with the development of metastases in BC patients. Mechanistically, miR-23b is able to directly inhibit a number of genes implicated in cytoskeletal remodeling in BC cells. Through intracellular signal transduction, growth factors activate the transcription factor AP-1, and we show that this in turn reduces miR-23b levels by direct binding to its promoter, releasing the pro-invasive genes from translational inhibition. In aggregate, miR-23b expression invokes a sophisticated interaction network that co-ordinates a wide range of cellular responses required to alter the cytoskeleton during cancer cell motility.
Christophides T, Frampton AE, Cohen P, et al., 2013, Reactive lymphoid hyperplasia of the pancreas: a clinical conundrum., JOP, Vol: 14, Pages: 207-211
CONTEXT: Localized reactive lymphoid hyperplasia is a rare condition characterized by the presence of lymphoid follicles. CASE REPORT: We describe a case of a 60-year-old woman who presented with right upper quadrant pain and was found to have a reactive nodular hyperplasia of the pancreas involving the uncinate process, body and tail of the gland. Due to the multifocal distribution of these hypoechoic vascular lesions, a total pancreatectomy was performed since malignancy could not be safely excluded. CONCLUSION: There have been a handful of cases reporting reactive lymphoid hyperplasia affecting the pancreas; however, it is uncommon to perform such a radical pancreatic resection for this benign condition.
Hossain MA, Frampton AE, Chowdhury TT, et al., 2013, Biological vascular grafts for hemodialysis access, Expert Review of Medical Devices, Vol: 10, Pages: 171-175, ISSN: 1743-4440
Evaluation of: Tillman BW, Yazdani SK, Neff LP et al. Bioengineered vascular access maintains structural integrity in response to arteriovenous flow and repeated needle puncture. J. Vasc. Surg. 56(3), 783-793 (2012). Alternatives to autogenous arteriovenous hemodialysis (HD) access, such as synthetic arteriovenous bypass grafts and central venous catheters, are associated with a higher rate of complications. The evaluated article assessed the repeated cannulation challenges of HD in tissue-engineered blood vessels implanted in a bovine in vivo model (n = 15). Two groups were studied. A short-term group in which the graft was explanted and histologically examined (n = 7) and a second group in which the graft was left in for 6 months or until outflow venous stenosis occurred (n = 8). Two grafts from each group occluded 1-month postoperatively. Of the 11 remaining, cannulation was well tolerated with adequate hemostasis. Histological analysis demonstrated host cell repopulation of the outer surface in the short-term group (n = 5) and stable wall geometry in the long-term group. The authors concluded that their study proves the concept of using a scaffold-based approach to tissue-engineered blood vessels for HD access. © 2013 2013 Expert Reviews Ltd.
Caponi S, Funel N, Frampton AE, et al., 2013, The good, the bad and the ugly: a tale of miR-101, miR-21 and miR-155 in pancreatic intraductal papillary mucinous neoplasms, ANNALS OF ONCOLOGY, Vol: 24, Pages: 734-741, ISSN: 0923-7534
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- Citations: 71
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