Imperial College London
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DrAdamFrampton

Faculty of Medicine, Department of Surgery & Cancer

Honorary Clinical Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 2125a.frampton

 
 
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Location

 

4005Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jiao:2019:10.3390/cancers11030302,
author = {Jiao, LR and Fajardo, Puerta AB and Gall, TMH and Sodergren, MH and Frampton, AE and Pencavel, T and Nagendran, M and Habib, NA and Darzi, A and Pai, M and Thomas, R and Tait, P},
doi = {10.3390/cancers11030302},
journal = {Cancers},
title = {Rapid induction of liver regeneration for major hepatectomy (REBIRTH): A randomized controlled trial of portal vein embolisation versus ALPPS assisted with radiofrequency.},
url = {http://dx.doi.org/10.3390/cancers11030302},
volume = {11},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - To avoid liver insufficiency following major hepatic resection, portal vein embolisation (PVE) is used to induce liver hypertrophy pre-operatively. Associating liver partition with portal vein ligation for staged hepatectomy assisted with radiofrequency (RALPPS) was introduced as an alternative method. A randomized controlled trial comparing PVE with RALPPS for the pre-operative manipulation of liver volume in patients with a future liver remnant volume (FLRV) ≤25% (or ≤35% if receiving preoperative chemotherapy) was conducted. The primary endpoint was increase in size of the FLRV. The secondary endpoints were length of time taken for the volume gain, morbidity, operation length and post-operative liver function. Between July 2015 and October 2017, 57 patients were randomised to RALPPS (n = 29) and PVE (n = 28). The mean percentage of increase in the FLRV was 80.7 ± 13.7% after a median 20 days following RALPPS compared to 18.4 ± 9.8% after 35 days (p < 0.001) following PVE. Twenty-four patients after RALPPS and 21 after PVE underwent stage-2 operation. Final resection was achieved in 92.3% and 66.6% patients in RALPPS and PVE, respectively (p = 0.007). There was no difference in morbidity, and one 30-day mortality after RALPPS (p = 0.991) was reported. RALPPS is more effective than PVE in increasing FLRV and the number of patients for surgical resection.
AU  - Jiao,LR
AU  - Fajardo,Puerta AB
AU  - Gall,TMH
AU  - Sodergren,MH
AU  - Frampton,AE
AU  - Pencavel,T
AU  - Nagendran,M
AU  - Habib,NA
AU  - Darzi,A
AU  - Pai,M
AU  - Thomas,R
AU  - Tait,P
DO  - 10.3390/cancers11030302
PY  - 2019///
SN  - 2072-6694
TI  - Rapid induction of liver regeneration for major hepatectomy (REBIRTH): A randomized controlled trial of portal vein embolisation versus ALPPS assisted with radiofrequency.
T2  - Cancers
UR  - http://dx.doi.org/10.3390/cancers11030302
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30836678
UR  - http://hdl.handle.net/10044/1/69022
VL  - 11
ER  -
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