Imperial College London
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DrAdamFrampton

Faculty of Medicine, Department of Surgery & Cancer

Honorary Clinical Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 2125a.frampton

 
 
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Location

 

4005Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Liu:2022:10.3390/ijms23073692,
author = {Liu, D and Yang, QZC and Asim, M and Krell, J and Frampton, A},
doi = {10.3390/ijms23073692},
journal = {International Journal of Molecular Sciences},
title = {The clinical significance of transfer RNAs present in extracellular vesicles},
url = {http://dx.doi.org/10.3390/ijms23073692},
volume = {23},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Extracellular vesicles (EVs) are important for intercellular signalling in multi-cellular organ-isms. However, the role of mature transfer RNAs (tRNAs) and tRNA fragments in EVs has yet to be characterised. This systematic review aimed to identify up-to-date literature on tRNAs pre-sent within human EVs and explores their potential clinical significance in health and disease. A comprehensive and systematic literature search was performed, and the study was conducted in accordance with PRISMA guidelines. Electronic databases MEDLINE and EMBASE were searched up until 1st January 2022. From 685 papers, 60 studies were identified for analysis. The majority of papers reviewed focussed on the role of EV tRNAs in cancers (31.7%), with numerous other conditions represented. Blood and cell lines were the most common EV sources, representing 85.9% of protocols used. EV isolation methods included the most known methods, precipitation being the most common (49.3%). The proportion of EV tRNAs was highly variable, ranging be-tween 0.04% to >95% depending on tissue source. EV tRNAs are present in a multitude of sources and show promise as disease markers in breast cancer, gastrointestinal cancers, and other diseases. EV tRNA research is an emerging field, with increasing numbers of papers highlighting novel methodologies for tRNA and tRNA fragment discovery.
AU  - Liu,D
AU  - Yang,QZC
AU  - Asim,M
AU  - Krell,J
AU  - Frampton,A
DO  - 10.3390/ijms23073692
PY  - 2022///
SN  - 1422-0067
TI  - The clinical significance of transfer RNAs present in extracellular vesicles
T2  - International Journal of Molecular Sciences
UR  - http://dx.doi.org/10.3390/ijms23073692
UR  - http://hdl.handle.net/10044/1/96665
VL  - 23
ER  -
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