Publications
448 results found
Raue F, Späth-Röger M, Winter J, et al., 1990, [A registry of medullary thyroid cancer in West Germany]., Med Klin (Munich), Vol: 85, Pages: 113-169, ISSN: 0723-5003
A register for medullary thyroid carcinoma (MTC) in FRG has been set up by the "German Medullary Thyroid Carcinoma Study Group" in 1988. The aim is to provide a basis for collaborative work on MTC especially in the hereditary forms (i.e. multiple endocrine neoplasia [MEN] type IIa, IIb). For these hereditary varieties reliable screening tests exist and, if the disease is detected by family screening in an early stage, curative surgery is possible. Until now 408 patients (234 female, 174 male) with MTC have been reported by 17 cooperative centers. The mean age at diagnosis was 45.5 years. 25% (n = 104) are hereditary forms, most of them MEN IIa (n = 86), 13 are MEN IIb and 18 belong to the familial variety without other endocrinopathy. The mean age at diagnosis for MEN IIa was 36.5 years, MEN IIb 26.9 and for the pure familial form 27.5 years. As 33 patients per year have been diagnosed since 1982, nearly 25% of all expected cases of MTC in FRG have been registered.
RAUE F, SPATHROGER M, WINTER J, et al., 1990, REGISTER FOR MEDULLARY-THYROID CARCINOMA IN FRG, MEDIZINISCHE KLINIK, Vol: 85, Pages: 113-116, ISSN: 0723-5003
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- Citations: 9
Frilling A, Goretzki PE, Röher HD, 1990, [Iodine-induced crisis in thyroid autonomy: a surgical emergency]., Acta Med Austriaca, Vol: 17 Suppl 1, Pages: 86-87, ISSN: 0303-8173
Frilling A, Goretzki PE, Röher HD, 1990, [Progress in the diagnosis and therapy of C cell carcinoma of the thyroid gland]., Langenbecks Arch Chir, Vol: 375, Pages: 333-339, ISSN: 0023-8236
Between 1986 and 1989 172 patients were operated on thyroid cancer. Twenty-nine (17%) of them had a medullary carcinoma. In 20 of these patients (69%) the carcinoma occurred in a sporadic and in 9 (31%) patients in a familial form. Eighteen patients (62%) had to be operated because of tumor recurrence and in 4 of them additional surgery was necessary because of distant metastases. Due to tumor recurrence 7 patients underwent multiple operations during the above period. Adequate first operation was performed only in 6 patients (33%). Based on family screening a carcinoma was diagnosed in 4 patients in its occult stage. Diagnostic methods include biochemical and imaging methods. Calcitonin is the most sensitive tumor marker. Basal and stimulated serum calcitonin analysis provides a very efficient method to detect medullary carcinoma in early tumor stage and to treat the disease curatively. DNA-analysis improves early diagnosis of persons at risk.
Röher HD, Goretzki PE, Frilling A, 1990, [Therapeutic strategy and prognosis of malignant struma]., Zentralbl Chir, Vol: 115, Pages: 389-397, ISSN: 0044-409X
The systematic application of combined treatment modalities including surgery, radiotherapy and suppressive hormone administration is based on a biologically relevant histomorphologic tumour classification. Although the principle of an aggressive therapeutic approach is still valid meantime a limited radicality has proven equally successful for selected early cases. On the other hand an even extended radical strategy is followed by repeated surgery for local recurrencies and metastatic lesions.
ROHER HD, GORETZKI PE, FRILLING A, 1990, THERAPEUTIC STRATEGY AND PROGNOSIS OF MALIGNANT THYROID-TUMORS, ZENTRALBLATT FUR CHIRURGIE, Vol: 115, Pages: 389-397, ISSN: 0044-409X
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- Citations: 1
FRILLING A, GORETZKI PE, ROHER HD, 1990, IODINE INDUCED THYROTOXIC CRISES IN THYROID AUTONOMY - VALUE OF EARLY SURGERY, 3RD THYROID SYMP ON PATHOGENESIS OF THYROID AUTONOMY, Publisher: BLACKWELL WISSENSCHAFTS-VERLAG GMBH, Pages: 86-87, ISSN: 0303-8173
FRILLING A, GORETZKI PE, ROHER HD, 1990, PROGRESS IN THE DIAGNOSTICS AND THERAPY OF MEDULLARY-THYROID CARCINOMA, LANGENBECKS ARCHIV FUR CHIRURGIE, Vol: 375, Pages: 333-339, ISSN: 0023-8236
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- Citations: 3
Goretzki PE, Frilling A, Simon D, et al., 1990, Growth regulation of normal thyroids and thyroid tumors in man., Recent Results Cancer Res, Vol: 118, Pages: 48-63, ISSN: 0080-0015
Our studies using thyrocyte membranes from different human thyroid tissues, monolayer cultures of human thyrocytes, and the permanant cell line FTC-133 demonstrate the stimulatory effect of TSH on metabolism, DNA synthesis, and cell growth in human thyrocytes. Up- and down-regulation of cAMP cell content fails to show direct effects on DNA synthesis and cell growth in primary thyrocyte cultures in man. Increased AC responsiveness to TSH in adenomatous human thyroid tissues, when compared to normal thyroids of the same patient (p less than 0.005), is thus of only questionable importance for thyroid tumor growth. The permanant cell line FTC-133 was established from differentiated follicular human thyroid cancer cells. FTC-133 cells proved to be of particular usefulness in assessing growth regulation of human thyroid tissue. These cells could be propagated in serum free medium, showed thyroglobulin immunoreactivity and EGF receptors, lacked any fibroblast contamination, and responded to TSH and local active growth factors such as EGF and IGF with a stimulated [3H]thymidine incorporation. The latter could be shown in primary cell cultures of normal and pathological human thyrocytes as well. Additional to the stimulatory effect of TSH and IGF on [3H]thymidine incorporation, these substances show an additive effect when incubated simultaneously. Locally active growth factors and endocrine growth stimulation by TSH therefore act synergistically on thyrocyte growth in human thyrocyte cultures. Whether the TSH effect on cell growth is related to its stimulation of AC remains as yet questionable.
GORETZKI PE, FRILLING A, GRUSSENDORF M, et al., 1989, SURGICAL THERAPY OF THYROID AUTONOMY, NUKLEARMEDIZINER, Vol: 12, Pages: 251-255, ISSN: 0723-7065
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- Citations: 1
Röher HD, Goretzki PE, Wahl RA, et al., 1989, [Intrathoracic struma]., Chirurg, Vol: 60, Pages: 384-390, ISSN: 0009-4722
ROHER HD, GORETZKI PE, WAHL RA, et al., 1989, INTRATHORACIC GOITER, CHIRURG, Vol: 60, Pages: 384-390, ISSN: 0009-4722
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- Citations: 4
GORETZKI PE, FRILLING A, OHMANN C, et al., 1989, VARIOUS STRATEGIES IN THE DIAGNOSIS AND TREATMENT OF THYROID CARCINOMAS, CHIRURG, Vol: 60, Pages: 398-402, ISSN: 0009-4722
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- Citations: 5
Goretzki PE, Frilling A, Ohmann C, et al., 1989, [Various strategies in the diagnosis and therapy of thyroid gland cancer. Results of a survey]., Chirurg, Vol: 60, Pages: 398-402, ISSN: 0009-4722
In a questionnaire we compared generally adviced therapeutical and technical procedures in patients with thyroid carcinomas with the actually favorized strategy of the clinically active surgeons. At present, sonography and cytology are not favored as preoperative diagnostic tools by the questioned surgeons. Hemithyreoidectomy as primary procedure in suspicious nodules is performed only seldomly. In the treatment of thyroid carcinoma total thyroidectomy is the accepted procedure and the possibility of restricted radicality in the treatment of papillary thyroid carcinomas has gained wide acknowledgement. Most surgeons prefer to visualize the recurrent nerve and at least one or two parathyroid glands. Autotransplantation of parathyroid glands with insufficient blood supply is considered only seldomly.
Röher HD, Goretzki PE, Frilling A, 1989, [Indications for and basic principles of the surgical treatment of thyroid diseases]., Radiologe, Vol: 29, Pages: 119-124, ISSN: 0033-832X
Surgical treatment is indicated for patients with nodular goiter if malignancy seems possible, if there are mechanical reasons, or on request from the patient. In patients with goiter and hyperthyroidism, surgery and radioiodine are alternatives. In contrast, thyroid autonomy always requires surgery. The treatment of patients suffering from differentiated thyroid cancer includes thyroidectomy and radioiodine, and in those with anaplastic thyroid cancer external radiation and surgery should be performed. Apart from the classic indications and surgical procedures, in recent years selective resection of multinodular goiter, more conservative surgery of small papillary thyroid cancer and surgical treatment of iodine-induced thyrotoxicosis have become established.
ROHER HD, GORETZKI PE, FRILLING A, 1989, INDICATIONS FOR AND PRINCIPLES OF SURGICAL THERAPY FOR THYROID-DISEASES, RADIOLOGE, Vol: 29, Pages: 119-124, ISSN: 0033-832X
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- Citations: 8
GORETZKI PE, FRILLING A, GRUSSENDORF M, et al., 1989, SURGICAL-TREATMENT OF HYPERTHYROIDISM, AKTUELLE CHIRURGIE, Vol: 24, Pages: 47-52, ISSN: 0001-785X
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- Citations: 1
GORETZKI PE, FRILLING A, SIMON D, et al., 1989, GROWTH-REGULATION OF HUMAN THYROCYTES BY THYROTROPIN, CYCLIC ADENOSINE-MONOPHOSPHATE, EPIDERMAL GROWTH-FACTOR AND INSULIN-LIKE GROWTH-FACTOR, FRONTIERS OF HORMONE RESEARCH, Vol: 18, Pages: 56-80, ISSN: 0301-3073
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- Citations: 10
Frilling A, Goretzki PE, Bastian L, et al., 1989, The importance of screening for medullary thyroid carcinoma in families of patients with MEN 2., Henry Ford Hosp Med J, Vol: 37, Pages: 122-123, ISSN: 0018-0416
Family screening for medullary thyroid cancer (MTC) is important for detecting members of multiple endocrine neoplasia type 2 (MEN 2) families who may be gene carriers but show no clinical evidence of the disease. Most members of our MEN 2 families are screened yearly by measuring basal and pentagastrin-stimulated calcitonin (CT) levels. A 15-year-old first-degree relative of an affected member of the D-kindred showed a normal basal and an elevated stimulated CT level. Clinical examination, ultrasonography, and scintigraphy were normal. Thyroidectomy and bilateral neck dissection revealed a multicentric MTC with no lymph node involvement. In the O-kindred we detected elevated basal and/or stimulated CT levels in three asymptomatic first-degree relatives. At surgery we found a small multicentric MTC in one family member, C-cell hyperplasia in another member, and bilateral lymph node metastases in one member who had been previously thyroidectomized. Basal and stimulated CT estimations in MEN 2 family members provide an effective method for detecting MTC in early, treatable stages.
GORETZKI PE, FRILLING A, SIMON D, et al., 1989, GROWTH-REGULATION OF HUMAN THYROCYTES BY THYROTROPIN, CYCLIC ADENOSINE-MONOPHOSPHATE, EPIDERMAL GROWTH-FACTOR AND INSULIN-LIKE GROWTH-FACTOR, WORKSHOP ON GROWTH REGULATION OF THYROID GLAND AND THYROID TUMORS, Publisher: KARGER, Pages: 56-80
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- Citations: 13
ROHER HD, GORETZKI PE, FRILLING A, 1988, THYROID-STIMULATING ANTIBODIES OF GRAVES-DISEASE IN THYROID-CANCER, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 319, Pages: 1669-1670, ISSN: 0028-4793
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- Citations: 5
FRILLING A, GORETZKI PE, ROHER HD, 1988, PERSISTING POSTOPERATIVE HYPERTHYROIDISM - A SURGICAL PROBLEM, WIENER MEDIZINISCHE WOCHENSCHRIFT, Vol: 138, Pages: 450-451, ISSN: 0043-5341
FRILLING A, GRABITZ K, NIER H, 1986, PRIMARY RETROPERITONEAL TUMORS, DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, Vol: 111, Pages: 1636-1641, ISSN: 0012-0472
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- Citations: 1
FRILLING A, AUTSCHBACH R, GOMEZ JR, et al., 1986, COLD THYROID-NODULES - AN ABSOLUTE OPERATIVE INDICATION, LANGENBECKS ARCHIV FUR CHIRURGIE, Vol: 369, Pages: 207-208, ISSN: 0023-8236
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- Citations: 2
Frilling A, Autschbach R, Gomez JR, et al., 1986, [Cold struma nodule--an absolute surgical indication?]., Langenbecks Arch Chir, Vol: 369, Pages: 207-208, ISSN: 0023-8236
From 1969 to 1984 3,972 operations of the thyroid gland were performed. 3,540 scintigraphic findings were evaluated retrospectively. In 2,013 (57%) cases one or more so-called cold thyroid nodules were found. The malignancy rate in these nodules was 5.6%. The fine needle biopsy and cytology gave in 17.9% false-negative results. Based on a malignancy rate of 5.6%, rather high false-negative results of fine needle biopsy and acceptable postoperative complication rate we estimate strict operative indication.
FRILLING A, NIER H, KREMER K, 1985, TREATMENT OF CARCINOMA OF THE CARDIA STUDY OF 131 CASES, AKTUELLE CHIRURGIE, Vol: 20, Pages: 228-231, ISSN: 0001-785X
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- Citations: 1
Körfer R, Bircks W, Frilling A, et al., 1984, [Reoperation following correction of partial defects of the endocardial cushion (indication, incidence, results)]., Z Kardiol, Vol: 73, Pages: 269-272, ISSN: 0300-5860
In the period between 1955 and 1982, 297 patients underwent surgical correction of a partial AV-canal. Closure of the ostium primum defect was performed either by direct suture or by patch (prosthetic material or pericardium). Only in cases with severe mitral incompetence was the cleft in the anterior leaflet of the mitral valve surgically treated. At an average of 6 years (range: 3 months - 22 years) after the initial procedure 21 patients (7.8 per cent) underwent reoperation. In 20 patients reoperation was necessary for hemodynamic reasons (recurrence of ASD: n = 8; severe AV-valve regurgitation: n = 3; or both: n = 9). One patient with moderate mitral valve incompetence suffered from severe "patch-hemolysis" due to direction of the blood-jet towards the prosthetic patch. Residual or recurrent atrial septal defects were closed by using a patch in cases with previous direct suture (39 patients - 8 reoperations) or by reinsertion or enlargement of the present patch (258 patients - 13 reoperations). AV-valve incompetence could be treated in all cases but two with reconstructive methods. In two patients implantation of a prosthetic valve was necessary. In the single case with "patch-hemolysis" the previous prosthetic patch was replaced by a pericardial one, together with a suture of the mitral cleft 3 months after operation. Mortality of reoperation was 14.5 per cent (3 early deaths). Major complications in the surviving patients did not occur, with one exception: one patient with postoperative total AV-block received a permanent pacemaker.
KORFER R, BIRCKS W, FRILLING A, et al., 1984, REOPERATION AFTER CORRECTION OF PARTIAL ATRIOVENTRICULAR-CANAL DEFECTS (INDICATION, INCIDENCE, RESULTS), ZEITSCHRIFT FUR KARDIOLOGIE, Vol: 73, Pages: 269-272, ISSN: 0300-5860
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