Publications
448 results found
Kuehl H, Stattaus J, Kuehl B, et al., 2006, Radiofrequency ablation of malignant liver tumors:: Use of a volumetric necrosis-tumor ratio for local control, ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN, Vol: 178, Pages: 1243-1249, ISSN: 1438-9029
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- Citations: 6
Erim Y, Beckmann M, Valentin-Gamazo C, et al., 2006, Quality of life and psychiatric complications after adult living donor liver transplantation, LIVER TRANSPLANTATION, Vol: 12, Pages: 1782-1790, ISSN: 1527-6465
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- Citations: 60
Frilling A, Weber F, Saner F, et al., 2006, Treatment with <SUP>90</SUP>Y- and <SUP>177</SUP>Lu-DOTATOC in patients with metastatic neuroendocrine tumors, SURGERY, Vol: 140, Pages: 968-976, ISSN: 0039-6060
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- Citations: 74
Pasieka JL, Frilling A, Skogseid B, 2006, Treatment with <SUP>90</SUP>Y- and <SUP>177</SUP>Lu-DOTATOC in patients with metastatic neuroendocrine tumors -: Discussion, SURGERY, Vol: 140, Pages: 976-977, ISSN: 0039-6060
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- Citations: 15
Sotiropoulos GC, Molmenti EP, Omar OS, et al., 2006, Liver transplantation for hepatocellular carcinoma in patients beyond the Milan but within the UCSF criteria, EUROPEAN JOURNAL OF MEDICAL RESEARCH, Vol: 11, Pages: 467-470, ISSN: 0949-2321
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- Citations: 7
Radtke A, Nadalin S, Sotiropoulos GC, et al., 2006, Parenchyma transection in adult live donor liver transplantation:: The virtual dilemma of "where to cut".: Experience based on virtual 3-dimensional computed tomography imaging reconstructions, HEPATO-GASTROENTEROLOGY, Vol: 53, Pages: 811-815, ISSN: 0172-6390
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- Citations: 11
Freudenberg LS, Frilling A, Sheu S-Y, et al., 2006, Optimizing preoperative imaging in primary hyperparathyroidism, LANGENBECKS ARCHIVES OF SURGERY, Vol: 391, Pages: 551-556, ISSN: 1435-2443
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- Citations: 14
Sotiropoulos GC, Frilling A, Molmenti EP, et al., 2006, De novo hepatocellular carcinoma in recurrent liver cirrhosis after liver transplantation for benign hepatic disease:: Is a deceased donor re-transplantation justified?, TRANSPLANTATION, Vol: 82, Pages: 1112-1112, ISSN: 0041-1337
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- Citations: 13
Radecke K, Lang H, Frilling A, et al., 2006, Successful sealing of benign esophageal leaks after temporary placement of a self-expanding plastic stent without fluoroscopic guidance, ZEITSCHRIFT FUR GASTROENTEROLOGIE, Vol: 44, Pages: 1031-1038, ISSN: 0044-2771
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- Citations: 18
Sotiropoulos GC, Molmenti EP, Frilling A, et al., 2006, Liver transplantation for double primary hepatic cancer-hepatocellular carcinoma and intrahepatic cholangiocarcinoma, TRANSPLANTATION, Vol: 82, Pages: 718-719, ISSN: 0041-1337
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- Citations: 2
Sotiropoulos GC, Lang H, Fruehauf NR, et al., 2006, Split liver transplantation for hepatocellular carcinoma, HEPATO-GASTROENTEROLOGY, Vol: 53, Pages: 764-767, ISSN: 0172-6390
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- Citations: 6
Weber F, Radmacher M, Broesch CE, et al., 2006, Over expression of human microRNAs contribute to follicular thyroid carcinogenesis (FTC), 61st Annual Session of the Surgical Forum 2006 Clinical Congress, Publisher: ELSEVIER SCIENCE INC, Pages: S47-S47, ISSN: 1072-7515
Lang H, Sotiropoulos GC, Brokalaki EI, et al., 2006, Left hepatic trisectionectomy for hepatobiliary malignancies, JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, Vol: 203, Pages: 311-321, ISSN: 1072-7515
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- Citations: 43
Weber F, Teresi RE, Broelsch CE, et al., 2006, A limited set of human MicroRNA is deregulated in follicular thyroid carcinoma, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 91, Pages: 3584-3591, ISSN: 0021-972X
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- Citations: 232
Sotiropoulos GC, Paul A, Gerling T, et al., 2006, Liver transplantation with "rescue organ offers" within the Eurotransplant area:: A 2-year report from the University Hospital Essen, TRANSPLANTATION, Vol: 82, Pages: 304-309, ISSN: 0041-1337
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- Citations: 25
Frilling A, Malago M, Weber F, et al., 2006, Liver transplantation for patients with metastatic endocrine tumors: Single-center experience with 15 patients, LIVER TRANSPLANTATION, Vol: 12, Pages: 1089-1096, ISSN: 1527-6465
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- Citations: 71
Hass HG, Jobst J, Nehls O, et al., 2006, The gene coding for secreted phosphoprotein1/osteopontin is the most overexpressed gene in cholangiocarcinoma - detected by oligonucleotide arrays and LightCycler analysis., 42nd Annual Meeting of the American-Society-of-Clinical-Oncology, Publisher: AMER SOC CLINICAL ONCOLOGY, Pages: 549S-549S, ISSN: 0732-183X
Hass HG, Jobst J, Nehls O, et al., 2006, The gene coding for secreted phosphoprotein1/osteopontin is the most overexpressed gene in cholangiocarcinoma-detected by oligonucleotide arrays and LightCycler analysis., J Clin Oncol, Vol: 24
10036 Background: Cholangiocarcinomas (CCC) are the second most common primary hepatic malignancy with a still poor prognosis and arise from biliary epithelia or cholangiocytes. Until now, less is known about the molecular pathways leeding to CCC. METHODS: Oligonucleotide arrays were used to analyze gene expression profiles of 8 intrahepatic CCCs. After isolation of tRNA and transcription into cDNA, biotin-labelled cRNA probes were hybridized to GeneArrays (Affymetrix U 133A) containing probes of more than 22.000 genes/ESTs. For two-dimensional cluster analysis we used special software programs (Genexplore, GeneSpring). Dysregulated genes were determined by presence in more than 70% and a 2-fold change in relation to the corresponding non-malignant liver tissue. Lightcycler analysis were performed to validate the expression datas of dysregulated genes. RESULTS: A total of 694 dysregulated genes (330 up-/364 down-regulated, compared with corresponding non-malignant tissue) were detected. As the gene with the highest and most consistent upregulation we were able to identify osteopontin (OPN) with an average 5-fold overexpression in all CCC tissues. OPN is an acidic phosphoprotein that is secreted by osteoblasts, macrophages and many other cell types and binds to a variety of cell surface receptors (integrins/CD44). OPN is multifunctional, with activities in cell migration, regulation of bone metabolism, immune cell function and control of tumor cell phenotype. Elevated OPN levels were seen in different tumors but until now no data exist about the expression in CCCs. As one possible interaction in human carcinogenesis, OPN has recently been shown to be a novel substrate for some MMPs, which play an importand role in tumor invasion and metastasis. CONCLUSIONS: This is the first report about an overexpression of OPN in CCC and our data indicate an important role in cholangiocarcinogenesis. Further studies are needed to illucidate the moleculargenetic mechanisms of OPN in
Bockhorn M, Malago M, Lang H, et al., 2006, The role of surgery in Caroll's disease, JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, Vol: 202, Pages: 928-932, ISSN: 1072-7515
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- Citations: 48
Malago M, Sotiropoulos GC, Nadalin S, et al., 2006, Living donor liver transplantation for hepatocellular carcinoma:: A single-center preliminary report, LIVER TRANSPLANTATION, Vol: 12, Pages: 934-940, ISSN: 1527-6465
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- Citations: 56
Sotiropoulos GC, Lang H, Frilling A, et al., 2006, Resectability of hepatocellular carcinoma:: Evaluation of 333 consecutive cases at a single hepatobiliary specialty center and systematic review of the literature, HEPATO-GASTROENTEROLOGY, Vol: 53, Pages: 322-329, ISSN: 0172-6390
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- Citations: 34
Li J, Dahmen U, Beckebaum S, et al., 2006, Target range maximum of cyclosporine blood concentration two hours post dose in stable liver transplant patients, EUROPEAN JOURNAL OF MEDICAL RESEARCH, Vol: 11, Pages: 139-145, ISSN: 0949-2321
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- Citations: 4
Lang H, Kaiser G, Zoepf T, et al., 2006, Surgical therapy of hilar cholangiocarcinoma, CHIRURG, Vol: 77, Pages: 325-334, ISSN: 0009-4722
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- Citations: 23
Iacob S, Beckebaum S, Cicinnati V, et al., 2006, Protective factors for severe recurrence of hepatitis C after liver transplantation, Digestive Disease Week/107th Annual Meeting of the American-Gastroenterological-Association, Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: A79-A80, ISSN: 0016-5085
Iacob S, Beckebaum S, Iacob R, et al., 2006, Predictive factors for graft and patient survival following liver transplantation for hepatitis C, Digestive Disease Week/107th Annual Meeting of the American-Gastroenterological-Association, Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: A500-A500, ISSN: 0016-5085
Nadalin S, Malagó M, Testa G, et al., 2006, "Hepar divisum" -: As a rare donor complication after intraoperative mortality of the recipient of an intended living donor liver transplantation, LIVER TRANSPLANTATION, Vol: 12, Pages: 428-434, ISSN: 1527-6465
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- Citations: 12
Sotiropoulos GC, Lang H, Frühauf NR, et al., 2006, In situ splitting of deceased donor livers:: An additional option for patients with hepatocellular carcinoma in cirrhosis, SURGERY, Vol: 139, Pages: 452-452, ISSN: 0039-6060
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- Citations: 2
Sotiropoulos GC, Malagó M, Molmenti EP, et al., 2006, Liver transplantation and incidentally found hepatocellular carcinoma in liver explants:: Need for a new definition?, TRANSPLANTATION, Vol: 81, Pages: 531-535, ISSN: 0041-1337
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- Citations: 28
Frilling A, Weber F, 2006, [Prophylactic thyroid surgery]., Chirurg, Vol: 77, Pages: 6-14, ISSN: 0009-4722
Early diagnosis for thyroid carcinoma, potentially before neoplastic transformation has taken place, would allow preventive and thus curative surgical intervention. Identifying and characterizing the RET proto-oncogene as the disease-causing gene for hereditary medullary thyroid carcinoma and then establishing a genotype-phenotype correlation served as the prerequisite for the risk-adapted prophylactic surgical approach practised today. Carriers of RET mutations associated with very aggressive tumour behaviour should be subjected to prophylactic thyroidectomy within the 1st year of life. For individuals harbouring less virulent types of mutations, prophylactic intervention is recommended at 5-20 years. Although genetic research on hereditary nonmedullary thyroid cancer is still in progress, initial results indicate the need of prophylactic surgical treatment also for this subgroup of thyroid neoplasia.
Sarquis MS, Weber F, Shen L, et al., 2006, High frequency of loss of heterozygosity in imprinted, compared with nonimprinted, genomic regions in follicular thyroid carcinomas and atypical adenomas, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 91, Pages: 262-269, ISSN: 0021-972X
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- Citations: 21
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