Imperial College London
Alternate

Prof Amparo Galindo

Faculty of Engineering, Department of Chemical Engineering

Co-Director Institute for Molecular Science and Engineering
 
 
 
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Contact

 

+44 (0)20 7594 5606a.galindo

 
 
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Location

 

604Roderic Hill BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Muhieddine:2022:10.1016/B978-0-323-95879-0.50101-6,
author = {Muhieddine, MH and Jonuzaj, S and Viswanath, SK and Armstrong, A and Galindo, A and Adjiman, CS},
booktitle = {Computer Aided Chemical Engineering},
doi = {10.1016/B978-0-323-95879-0.50101-6},
pages = {601--606},
title = {Model-based solvent selection for integrated synthesis, crystallisation and isolation processes},
url = {http://dx.doi.org/10.1016/B978-0-323-95879-0.50101-6},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - CHAP
AB  - We present a systematic process-wide solvent selection tool based on computer-aided mixture/blend design (CAMbD) (Gani, 2004) for the integrated synthesis, crystallisation and isolation of pharmaceutical compounds. The method proposed simultaneously identifies the solvent and/or anti-solvent mixture, mixture composition and process temperatures that optimise one or more key performance indicators. Additionally, the method entails comprehensive design specifications for the integrated process, such as the miscibility of the synthesis, crystallisation and wash solvents. The design approach is illustrated by identifying solvent mixtures for the synthesis, crystallisation and isolation of mefenamic acid. Furthermore, a multi-objective CAMbD problem is formulated and shows that a mefenamic acid with purity of 98.8% can be achieved without significant loss of process performance in terms of the solvent E-factor.
AU  - Muhieddine,MH
AU  - Jonuzaj,S
AU  - Viswanath,SK
AU  - Armstrong,A
AU  - Galindo,A
AU  - Adjiman,CS
DO  - 10.1016/B978-0-323-95879-0.50101-6
EP  - 606
PY  - 2022///
SP  - 601
TI  - Model-based solvent selection for integrated synthesis, crystallisation and isolation processes
T1  - Computer Aided Chemical Engineering
UR  - http://dx.doi.org/10.1016/B978-0-323-95879-0.50101-6
ER  -
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