Publications
193 results found
Martarello L, Parmar J, Dyer G, et al., 2009, STERILE VIAL FILLING WITH PET RADIOPHARMACEUTICALS, JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, Vol: 52, Pages: S291-S291, ISSN: 0362-4803
Jennings L, Long N, Gee A, et al., 2009, PALLADIUM-NHC MEDIATED CARBONYLATION FOR THE PRODUCTION OF [11C]-AMIDES IN PET RADIOLABELLING, Publisher: JOHN WILEY & SONS LTD, Pages: S432-S432, ISSN: 0362-4803
Kealey S, Plisson C, Martarello L, et al., 2009, COPPER COMPLEXES FOR IMPROVED [11C]CARBON MONOXIDE REACTIVITY, Publisher: JOHN WILEY & SONS LTD, Pages: S5-S5, ISSN: 0362-4803
Miller P, Long N, Vilar R, et al., 2009, NOVEL MICROREACTOR TECHNOLOGIES FOR 11C RADIOLABELLING, Publisher: WILEY, Pages: S13-S13, ISSN: 0362-4803
Martarello L, Parmar J, Dyer G, et al., 2009, IMPROVING [11C]CO2 SPECIFIC ACTIVITY ON SIEMENS ECLIPSE CYCLOTRONS - THE GSK CLINICAL IMAGING CENTRE EXPERIENCE, Publisher: JOHN WILEY & SONS LTD, Pages: S247-S247, ISSN: 0362-4803
Plisson C, Huiban M, Pampols-Maso S, et al., 2009, AUTOMATED RADIOSYNTHESIS OF DOPAMINE D2,D3 RECEPTOR AGONIST LIGAND [11C]PHNO FOR HUMAN PET IMAGING STUDIES, Publisher: JOHN WILEY & SONS LTD, Pages: S282-S282, ISSN: 0362-4803
Miller PW, Jennings LE, deMello AJ, et al., 2009, A microfluidic approach to the rapid screening of palladium catalysed aminocarbonylation reactions, Advanced Synthesis and Catalysis, Vol: 351, Pages: 3260-3268
Kealey S, Miller PW, Long NJ, et al., 2009, Copper(I) scorpionate complexes and their application in palladium-mediated [<SUP>11</SUP>C]carbonylation reactions, CHEMICAL COMMUNICATIONS, Pages: 3696-3698, ISSN: 1359-7345
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- Citations: 62
Kealey S, Plisson C, Martarello L, et al., 2009, RAPID [11C]METHYLATION REACTIONS USING MICROFLUIDIC TECHNOLOGY, Publisher: JOHN WILEY & SONS LTD, Pages: S498-S498, ISSN: 0362-4803
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- Citations: 1
Rosso L, Gee AD, Gould IR, 2008, <i>Ab initio</i> computational study of positron emission tomography ligands interacting with lipid molecule for the prediction of nonspecific binding, JOURNAL OF COMPUTATIONAL CHEMISTRY, Vol: 29, Pages: 2397-2405, ISSN: 0192-8651
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- Citations: 22
Miller PW, Long NJ, Vilar R, et al., 2008, Synthetic radiolabelling strategies for radiotracers in Positron Emission Tomography (PET) imaging, Angewandte Chemie Int. Ed., Vol: 47, Pages: 8998-9033
Long NJ, Kealey S, Miller PW, et al., 2008, INOR 300-Trapping and release of carbon monoxide via copper(I) scorpionates: Toward the synthesis of radiolabeled amides for PET imaging, 236th National Meeting of the American-Chemical-Society, Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727
Long NJ, Miller PW, de Mello A, et al., 2008, INOR 301-New strategies for 11-carbon labeling in PET: From fast synthesis to microfluidics, 236th National Meeting of the American-Chemical-Society, Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727
Kealey S, Long NJ, Miller PW, et al., 2008, ScorpoPhos: a novel phosphine-nitrogen ligand containing a tris(pyrazolyl)borate ligand core, DALTON TRANSACTIONS, Pages: 2677-2679, ISSN: 1477-9226
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- Citations: 13
Gee AD, Martarello L, Passchier J, et al., 2008, Synthesis and Evaluation of [11C]SB207145 as the First In Vivo Serotonin 5-HT4 Receptor Radioligand for PET Imaging in Man, Current Radiopharmaceuticals, Vol: 1, Pages: 110-114, ISSN: 1874-4710
The aim of this work was to develop a PET radiotracer which would enable the study of central serotonin 5-H4 receptors in man using positron emission tomography (PET). A procedure was developed for labelling SB207145, a potent and selective 5-H4 antagonist, with the short-lived positron emitting radionuclide 11C. Alkylation of the corresponding desmethyl compound with 11C-methyl iodide afforded [11C]SB207145 in 50 – 60 % radiochemical yield (decay corrected to end of cyclotron bombardment), specific activities of > 50 GBq/μmole and radiochemical purities greater than 95%. PET studies in pig showed [11C]SB207145 rapidly entered the brain reaching peak concentrations at 10 - 20 mins post administration, followed by washout from tissue. In humans the tissue kinetics of the tracer was slower, reaching peak tissue concentrations at 30 – 60 mins post administration. In both species, the observed rank order of regional brain concentrations was striatum > thalamus > cortical regions > cerebellum, consistent with the known distribution and concentration of 5-H4 receptors from in vitro studies. In pig, on administration of 0.5 mg/kg SB207040, a selective 5-H4 antagonist, the specific binding of [11C]SB207145 was reduced to level of the cortex, demonstrating saturability of the 5-H4 receptor population. In conclusion, a new PET radioligand is described which enables the study of 5-H4 receptors in vivo in humans for the first time using PET.
Amitani M, Ohashi A, Hatazawa J, et al., 2008, Effect of PK11195 on attenuating the enhancement of glucose utilization induced by quinolinic acid infusion in the rat brain, SYNAPSE, Vol: 62, Pages: 253-258, ISSN: 0887-4476
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- Citations: 5
Parker CA, Cunningham VJ, Martarello L, et al., 2008, Evaluation of the novel 5-HT6 receptor radioligand, [<SUP>11</SUP>C]GSK-215083 in human, 7th International Symposium on Functional Neuroreceptor Mapping of the Living Brain, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: T20-T20, ISSN: 1053-8119
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- Citations: 13
Passchier J, Comley R, Salinas C, et al., 2008, The role of P-glycoprotein on blood brain barrier permeability of [<SUP>11</SUP>C]Loperamide in humans, 7th International Symposium on Functional Neuroreceptor Mapping of the Living Brain, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: T192-T192, ISSN: 1053-8119
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- Citations: 3
Casey DR, Sebai SC, Shearman GC, et al., 2008, Formulation affects the rate of membrane degradation catalyzed by cationic amphiphilic drugs, Industrial & Engineering Chemistry Research, Vol: 47, Pages: 650-655
Rosso L, Gee AD, Gould IR, 2008, Towards in silico descriptors of PET ligands non-specific binding, 7th International Symposium on Functional Neuroreceptor Mapping of the Living Brain, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: T99-T99, ISSN: 1053-8119
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- Citations: 1
Rabiner EA, Slifstein M, Gunn RN, et al., 2008, Contribution of D<sub>3</sub> receptors to the <i>in vivo</i> binding of [<SUP>11</SUP>C]PHNO in the primate brain, 7th International Symposium on Functional Neuroreceptor Mapping of the Living Brain, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: T39-T39, ISSN: 1053-8119
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- Citations: 7
Parker CA, Tyacke RJ, Rabiner EA, et al., 2008, [<SUP>11</SUP>C](+)RX-821024:: A novel tracer for imaging α<sub>2</sub>-adrenoceptors, 7th International Symposium on Functional Neuroreceptor Mapping of the Living Brain, Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, Pages: T98-T98, ISSN: 1053-8119
Betts HM, Barnard PJ, Bayly SR, et al., 2008, Controlled Axial Coordination: Solid-Phase Synthesis and Purification of Metallo-Radiopharmaceuticals, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 47, Pages: 8416-8419, ISSN: 1433-7851
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- Citations: 33
Momosaki S, Hosoi R, Sanuki T, et al., 2007, [<SUP>14</SUP>C]Benzyl acetate is a potential radiotracer for the measurement of glial metabolism in the rat brain, NUCLEAR MEDICINE AND BIOLOGY, Vol: 34, Pages: 939-944, ISSN: 0969-8051
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- Citations: 11
Fujita M, Zoghbi SS, Crescenzo MS, et al., 2007, Quantification of brain phosphodiesterase 4 in rat with (<i>R</i>)-[<SUP>11</SUP>C]rolipram-PET" (vol 26, pg 1201, 2005), NEUROIMAGE, Vol: 36, Pages: 1399-1399, ISSN: 1053-8119
Shearman GC, Attard GS, Hunt AN, et al., 2007, Using membrane stress to our advantage, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 35, Pages: 498-501, ISSN: 0300-5127
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- Citations: 17
Hirose S, Umetani Y, Amitani M, et al., 2007, Role of NMDA receptors in the increase of glucose metabolism in the rat brain induced by fluorocitrate, NEUROSCIENCE LETTERS, Vol: 415, Pages: 259-263, ISSN: 0304-3940
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- Citations: 15
Fujita M, Imaizumi M, D'Sa C, et al., 2007, In vivo and in vitro measurement of brain phosphodiesterase 4 in rats after antidepressant administration, SYNAPSE, Vol: 61, Pages: 78-86, ISSN: 0887-4476
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- Citations: 16
Shearman GC, Sebai SC, Mulet X, et al., 2007, A novel mechanism for drug transport through membranes, 51st Annual Meeting of the Biophysical-Society, Publisher: BIOPHYSICAL SOCIETY, Pages: 239A-240A, ISSN: 0006-3495
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