Publications
193 results found
Gillings NM, Gee AD, Inoue O, 1999, The synthesis of (<i>R</i>)- and (<i>S</i>)-[<i>N</i>-methyl-<SUP>11</SUP>C]β, β-difluoromethamphetamine for the investigation of the binding mechanism of biogenic amines <i>in vivo</i>, APPLIED RADIATION AND ISOTOPES, Vol: 50, Pages: 707-714, ISSN: 0969-8043
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- Citations: 4
Inoue O, Wakahara S, Kobayashi K, et al., 1999, Enhancement of <SUP>3</SUP>H-N-methylspiperone binding but not <SUP>3</SUP>H-raclopride binding in mouse striatum by MK-801:: evidence that factors other than competition by endogenous dopamine are responsible for changes in D<sub>2</sub> receptor binding in vivo, JOURNAL OF NEURAL TRANSMISSION, Vol: 106, Pages: 131-137, ISSN: 0300-9564
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- Citations: 5
Inoue O, Kobayashi K, Hosoi R, et al., 1999, Discrepancies in apparent dopamine D2 receptor occupancy between <SUP>3</SUP>H-raclopride and <SUP>3</SUP>H-N-methylspiperone, JOURNAL OF NEURAL TRANSMISSION, Vol: 106, Pages: 1099-1104, ISSN: 0300-9564
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- Citations: 8
Inoue O, Kobayashi K, Gee A, 1999, Changes in apparent rates of receptor binding in the intact brain in relation to the heterogeneity of reaction environments, CRITICAL REVIEWS IN NEUROBIOLOGY, Vol: 13, Pages: 199-225, ISSN: 0892-0915
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- Citations: 13
Smith DF, Poulsen PH, Ishizu K, et al., 1998, Quantitative PET analysis of regional cerebral blood flow and glucose and oxygen metabolism in response to fenfluramine in living porcine brain, JOURNAL OF NEUROSCIENCE METHODS, Vol: 86, Pages: 17-23, ISSN: 0165-0270
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- Citations: 17
Inoue O, Kobayashi K, Hosoi R, et al., 1998, Opposing effects of clomipramine on [<SUP>125</SUP>I]RTI-55 and [<SUP>3</SUP>H]N-methylspiperone binding in mouse striatum:: Important role of other factors than endogenous dopamine?, SYNAPSE, Vol: 30, Pages: 338-340, ISSN: 0887-4476
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- Citations: 4
Ostergaard L, Johannsen P, Host-Poulsen P, et al., 1998, Cerebral blood flow measurements by magnetic resonance imaging bolus tracking:: Comparison with [<SUP>15</SUP>O]H<sub>2</sub>O positron emission tomography in humans, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol: 18, Pages: 935-940, ISSN: 0271-678X
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- Citations: 172
Keiding S, Hansen SB, Rasmussen HH, et al., 1998, Detection of cholangiocarcinoma in primary sclerosing cholangitis by positron emission tomography, HEPATOLOGY, Vol: 28, Pages: 700-706, ISSN: 0270-9139
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- Citations: 142
Bender D, Gee AD, 1998, Solid phase-supported reaction of NCA H<SUP>11</SUP>CN with arabinose:: A simplified automated synthesis of D-[1-<SUP>11</SUP>C]glucose, JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, Vol: 41, Pages: 287-300, ISSN: 0362-4803
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- Citations: 4
Ostergaard L, Smith DF, Vestergaard-Poulsen P, et al., 1998, Absolute cerebral blood flow and blood volume measured by magnetic resonance imaging bolus tracking: Comparison with positron emission tomography values, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol: 18, Pages: 425-432, ISSN: 0271-678X
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- Citations: 151
Danielsen E, Smith DF, Poulsen PH, et al., 1998, Positron emission tomography of living brain in minipigs and domestic pigs, Symposium on the Minipig in Toxicology at the Eurotox 97 Meeting, Publisher: SCANDINAVIAN FEDERATION LABORATORY ANIMAL SCIENCE, Pages: 127-135, ISSN: 0901-3393
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- Citations: 16
Kobayashi K, Gee A, Hosoi R, et al., 1998, Changes in apparent in vivo binding of [<SUP>3</SUP>H]raclopride and [<SUP>3</SUP>H]N-methylspiperone induced by oxotremorine -: <i>Short communication</i>, JOURNAL OF NEURAL TRANSMISSION, Vol: 105, Pages: 1193-1197, ISSN: 0300-9564
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- Citations: 2
Danielsen EH, Smith DF, Gee AD, et al., 1998, Metabolism of [<SUP>18</SUP>F]fluorodopa in pig brain estimated by PET, 3rd International Conference on Quantification of Brain Function with PET (BRAINPET 97), Publisher: ELSEVIER ACADEMIC PRESS INC, Pages: 187-193
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- Citations: 1
Svensson P, Johannsen P, Jensen TS, et al., 1998, Cerebral blood-flow changes evoked by two levels of painful heat stimulation: a positron emission tomography study in humans, EUROPEAN JOURNAL OF PAIN, Vol: 2, Pages: 95-106, ISSN: 1090-3801
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- Citations: 25
Svensson P, Johannsen P, Jensen TS, et al., 1998, Cerebral blood-flow changes evoked by two levels of painful heat stimulation: a positron emission tomography study in humans., Eur J Pain, Vol: 2, Pages: 95-107
Positron emission tomography (PET) and accumulation of H(2)(15)O as a marker of neuronal activity were used to create maps of cerebral blood-flow changes evoked by painful heat stimulation in 10 subjects. Two levels of painful tonic and phasic heat stimuli were applied with use of a newly developed contact heat thermode on the volar surface of the dominant (right) arm. The subjects participated in two separate PET sessions. Maps reflecting low and high levels of painful tonic heat were obtained in the first session, and low and high levels of painful phasic heat in the second session. The subjects scored their peak pain intensity and unpleasantness on 10-cm visual analogue scales. For each subject, PET images were aligned to nuclear magnetic resonance (NMR) images and remapped into the standardized co-ordinate system of Talairach. After normalization of the PET volumes, subtraction images were formed voxel-by-voxel and converted to a t-statistic volume. The perceived pain intensity and unpleasantness were identical with painful tonic and phasic heat stimulation. Directed searches revealed significant blood-flow increases in the contralateral primary sensorimotor cortex (MI/SI), SII, insular cortex and cingulate cortex when the low tonic heat map was subtracted from the high. A similar, but not identical, pain-processing network was observed for the maps representing the subtraction of low and high phasic heat. In this subtraction, the blood-flow increases in MSI/SI did not reach statistical significance, and significant blood flow decreases were found in the contralateral middle temporal gyrus. Finally, the location of the activation site in the cingulate cortex was different from that observed during tonic heat pain. This study has provided more evidence for the existence of a common pain-processing network engaged during the perception of different levels of toxic and phasic heat pain. Copyright 1998 European Federation of Chapters of the International Association
Poulsen PH, Smith DF, Ostergaard L, et al., 1997, In vivo estimation of cerebral blood flow, oxygen consumption and glucose metabolism in the pig by [<SUP>15</SUP>O]water injection, [<SUP>15</SUP>O]oxygen inhalation and dual injections of [<SUP>18</SUP>F]fluorodeoxyglucose, JOURNAL OF NEUROSCIENCE METHODS, Vol: 77, Pages: 199-209, ISSN: 0165-0270
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- Citations: 48
Gee AD, Moldt P, Gjedde A, 1997, The labelling of a novel tropane derivative [C-11]NS 2214 (BMS-204756) - An inhibitor of the dopamine transporter, JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, Vol: 39, Pages: 959-972, ISSN: 0362-4803
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- Citations: 9
Hermansen F, Poulson PH, Danielsen E, et al., 1997, Parametric imaging of irreversible binding of C-11-NMSP requires weighted Patlak analysis (vol 5, pg A30, 1997), NEUROIMAGE, Vol: 6, Pages: 230-230, ISSN: 1053-8119
Keiding S, Roelsgaard K, Paaske W, et al., 1997, Hepatic blood perfusion and metabolism in intact pigs estimated by positron emission tomography (PET), HEPATOLOGY, Vol: 26, Pages: 595-595, ISSN: 0270-9139
Johannsen P, Jakobsen J, Bruhn P, et al., 1997, Cortical sites of sustained and divided attention in normal elderly humans, NEUROIMAGE, Vol: 6, Pages: 145-155, ISSN: 1053-8119
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- Citations: 73
Smith DF, Jensen PN, Gee AD, et al., 1997, PET neuroimaging with [C-11]venlafaxine: Serotonin uptake inhibition, biodistribution and binding in living pig brain, EUROPEAN NEUROPSYCHOPHARMACOLOGY, Vol: 7, Pages: 195-200, ISSN: 0924-977X
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- Citations: 31
Rasmussen HH, Keiding S, TageJensen U, et al., 1997, Detection of cholangiocarcinoma in patients with primary sclerosing cholangitis by positron emission tomography (PET)., GASTROENTEROLOGY, Vol: 112, Pages: A578-A578, ISSN: 0016-5085
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- Citations: 1
Botker HE, Bottcher M, Schmitz O, et al., 1997, Glucose uptake and lumped constant variability in normal human hearts determined with [F-18]fluorodeoxyglucose, JOURNAL OF NUCLEAR CARDIOLOGY, Vol: 4, Pages: 125-132, ISSN: 1071-3581
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- Citations: 65
Feldman HS, Hartvig P, Wiklund L, et al., 1997, Regional distribution of C-11-labeled lidocaine, bupivacaine, and ropivacaine in the heart, lungs, and skeletal muscle of pigs studied with positron emission tomography, BIOPHARMACEUTICS & DRUG DISPOSITION, Vol: 18, Pages: 151-164, ISSN: 0142-2782
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- Citations: 13
Gee AD, Smith DF, Gjedde A, 1997, The synthesis of [O-methyl-C-11]venlafaxine: A non-classical, fast-acting antidepressant, JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, Vol: 39, Pages: 89-95, ISSN: 0362-4803
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- Citations: 3
Svensson P, Johannsen P, Jensen TS, et al., 1997, Cerebral representation of graded painful phasic and tonic heat in humans: A positron emission tomography study, 8th World Congress on Pain, Publisher: INT ASSOC STUDY PAIN (IASP) PRESS, Pages: 867-878
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- Citations: 5
Gee AD, Gillings N, Smith D, et al., 1997, In vivo characterization of amphetamine binding sites, JOURNAL OF NEUROCHEMISTRY, Vol: 69, Pages: S222-S222, ISSN: 0022-3042
Moller N, Frystyk J, Skjaerbaek C, et al., 1996, Systemic and regional tumour metabolism in a patient with non-islet cell tumour hypoglycaemia: Role of increased levels of free insulin-like growth factors, DIABETOLOGIA, Vol: 39, Pages: 1534-1535, ISSN: 0012-186X
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- Citations: 5
Gee A, 1996, Chemistry of neuroreceptor ligands: From atoms to neurons, JOURNAL OF NEUROCHEMISTRY, Vol: 66, Pages: S67-S67, ISSN: 0022-3042
LEWIS P, GRIFFIN S, MARSDEN P, et al., 1994, WHOLE-BODY F-18 FLUORODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY IN PREOPERATIVE EVALUATION OF LUNG-CANCER, LANCET, Vol: 344, Pages: 1265-1266, ISSN: 0140-6736
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- Citations: 180
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