Imperial College London

Emeritus ProfessorAndrewGeorge

Faculty of MedicineDepartment of Surgery & Cancer

Emeritus Professor
 
 
 
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Contact

 

a.george

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

180 results found

Urch CE, George AJT, 2020, COVID-19: LESS HASTE, MORE SAFETY Let's stop talking about covid-safe and covid-secure-it's covid-mitigated, BMJ-BRITISH MEDICAL JOURNAL, Vol: 370, ISSN: 1756-1833

Journal article

Zhao H, Alam A, Pac Soo A, George AJT, Ma Det al., 2018, Ischemia-reperfusion injury reduces long term renal graft survival: mechanism and beyond, EBioMedicine, Vol: 28, Pages: 31-42, ISSN: 2352-3964

Ischemia-reperfusion injury (IRI) during renal transplantation often initiates non-specific inflammatory responses that can result in the loss of kidney graft viability. However, the long-term consequence of IRI on renal grafts survival is uncertain. Here we review clinical evidence and laboratory studies, and elucidate the association between early IRI and later graft loss. Our critical analysis of previous publications indicates that early IRI does contribute to later graft loss through reduction of renal functional mass, graft vascular injury, and chronic hypoxia, as well as subsequent fibrosis. IRI is also known to induce kidney allograft dysfunction and acute rejection, reducing graft survival. Therefore, attempts have been made to substitute traditional preserving solutions with novel agents, yielding promising results.

Journal article

Chatterjee J, Dai W, Abd Aziz NH, Teo PY, Wahba J, Phelps DL, Maine CJ, Whilding L, Dina R, Trevisan G, Flower K, George A, Ghaem-Maghami Set al., 2016, Clinical use of programmed cell death-1 (PD-1) and its ligand (PD-L1) expression as discriminatory and predictive markers in ovarian cancer, Clinical Cancer Research, Vol: 23, Pages: 3453-3460, ISSN: 1557-3265

Purpose We aimed to establish whether PD-1 and PD-L1 expression, in ovarian cancer (OC) tumour tissue and blood, could be used as biomarkers for discrimination of tumour histology and prognosis of OC. Experimental Design Immune cells were separated from blood, ascites and tumour tissue obtained from women with suspected OC and studied for the differential expression of possible immune biomarkers using flow cytometry. PD-L1 expression on tumour associated inflammatory cells was assessed by immunohistochemistry and tissue microarray. Plasma soluble PD-L1 was measured using sandwich ELISA. The relationships among immune markers were explored using hierarchical cluster analyses. Results Biomarkers from the discovery cohort that associated with PD-L1+ cells were found. PD-L1+ CD14+ cells and PD-L1+ CD11c+ cells in the monocyte gate showed a distinct expression pattern when comparing benign tumours and epithelial ovarian cancers (EOC) - confirmed in the validation cohort. Receiver operating characteristic curves showed PD-L1+ and PD-L1+ CD14+ cells in the monocyte gate performed better than the well-established tumour marker CA-125 alone. Plasma soluble PD-L1 was elevated in EOC patients compared to healthy women and patients with benign ovarian tumours. Low total PD-1+ expression on lymphocytes was associated with improved survival. Conclusions Differential expression of immunological markers relating to the PD-1/PD-L1 pathway in blood can be used as potential diagnostic and prognostic markers in EOC. These data have implications for the development and trial of anti PD-1/PD-L1 therapy in ovarian cancer.

Journal article

Teo PY, Yang C, Whilding LM, Parente-Pereira AC, Maher J, George AJT, Hedrick JL, Yang YY, Ghaem-Maghami Set al., 2015, Ovarian Cancer Immunotherapy Using PD-L1 siRNA Targeted Delivery from Folic Acid-Functionalized Polyethylenimine: Strategies to Enhance T Cell Killing, ADVANCED HEALTHCARE MATERIALS, Vol: 4, Pages: 1180-1189, ISSN: 2192-2640

Journal article

Zhao H, Huang H, Ologunde R, Lloyd DG, Watts H, Vizcaychipi MP, Lian Q, George AJT, Ma Det al., 2015, Xenon Treatment Protects against Remote Lung Injury after Kidney Transplantation in Rats, ANESTHESIOLOGY, Vol: 122, Pages: 1312-1326, ISSN: 0003-3022

Journal article

Mouratidis PXE, George AJT, 2015, Regulation of indoleamine 2,3-dioxygenase in primary human saphenous vein endothelial cells, JOURNAL OF INFLAMMATION RESEARCH, Vol: 8, Pages: 97-106, ISSN: 1178-7031

Journal article

Zhao H, Perez JS, Lu K, George AJT, Ma Det al., 2014, Role of Toll-like receptor-4 in renal graft ischemia-reperfusion injury, AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, Vol: 306, Pages: F801-F811, ISSN: 1931-857X

Journal article

Maine CJ, Aziz NHA, Chatterjee J, Hayford C, Brewig N, Whilding L, George AJT, Ghaem-Maghami Set al., 2014, Programmed death ligand-1 over-expression correlates with malignancy and contributes to immune regulation in ovarian cancer, CANCER IMMUNOLOGY IMMUNOTHERAPY, Vol: 63, Pages: 215-224, ISSN: 0340-7004

Journal article

Zhao H, Luo X, Zhou Z, Liu J, Tralau-Stewart C, George AJT, Ma Det al., 2014, Early treatment with xenon protects against the cold ischemia associated with chronic allograft nephropathy in rats, KIDNEY INTERNATIONAL, Vol: 85, Pages: 112-123, ISSN: 0085-2538

Journal article

Zhao H, Ning J, Savage S, Kang H, Lu K, Zheng X, George AJT, Ma Det al., 2013, A novel strategy for preserving renal grafts in an ex vivo setting: potential for enhancing the marginal donor pool, FASEB JOURNAL, Vol: 27, Pages: 4822-4833, ISSN: 0892-6638

Journal article

Teo PY, Yang C, Hedrick JL, Engler AC, Coady DJ, Ghaem-Maghami S, George AJT, Yang YYet al., 2013, Hydrophobic modification of low molecular weight polyethylenimine for improved gene transfection, BIOMATERIALS, Vol: 34, Pages: 7971-7979, ISSN: 0142-9612

Journal article

Zhao H, Yoshida A, Xiao W, Ologunde R, O'Dea KP, Takata M, Tralau-Stewart C, George AJT, Ma Det al., 2013, Xenon treatment attenuates early renal allograft injury associated with prolonged hypothermic storage in rats, FASEB JOURNAL, Vol: 27, Pages: 4076-4088, ISSN: 0892-6638

Journal article

Zhao H, Watts HR, Chong M, Huang H, Tralau-Stewart C, Maxwell PH, Maze M, George AJT, Ma Det al., 2013, Xenon Treatment Protects Against Cold Ischemia Associated Delayed Graft Function and Prolongs Graft Survival in Rats, AMERICAN JOURNAL OF TRANSPLANTATION, Vol: 13, Pages: 2006-2018, ISSN: 1600-6135

Journal article

Khan A, Fu H, Tan LA, Harper JE, Beutelspacher SC, Larkin DFP, Lombardi G, McClure MO, George AJTet al., 2013, Dendritic cell modification as a route to inhibiting corneal graft rejection by the indirect pathway of allorecognition, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 43, Pages: 734-746, ISSN: 0014-2980

Journal article

Zaher SS, Coe D, Chai J-G, Larkin DFP, George AJTet al., 2013, Suppression of the allogeneic response by the anti-allergy drug N-(3,4-dimethoxycinnamonyl) anthranilic acid results from T-cell cycle arrest, IMMUNOLOGY, Vol: 138, Pages: 157-164, ISSN: 0019-2805

Journal article

Chatterjee J, Haslinda Abdul Aziz N, Maine C, Hayford C, Whilding L, George AJT, Ghaem-Maghami Set al., 2012, Role of PD-L1 in In-vitro Interaction Between T-cells and Ovarian Tumour Cells, 22nd.Biennial Conference of European Association for Cancer Research, ISSN: 0959-8049

Conference paper

Lin W, Oh SKW, Choo ABH, George AJTet al., 2012, Activated T cells modulate immunosuppression by embryonic- and bone marrow-derived mesenchymal stromal cells through a feedback mechanism, CYTOTHERAPY, Vol: 14, Pages: 274-284, ISSN: 1465-3249

Journal article

Kamperidis P, Kamalati T, Ferrari M, Jones M, Garrood T, Smith MD, Diez-Posada S, Hughes C, Finucane C, Mather S, Nissim A, George AJT, Pitzalis Cet al., 2011, Development of a novel recombinant biotherapeutic with applications in targeted therapy of human arthritis, ARTHRITIS AND RHEUMATISM, Vol: 63, Pages: 3758-3767, ISSN: 0004-3591

Journal article

Fu H, Khan A, Coe D, Zaher S, Chai J-G, Kropf P, Mueller I, Larkin DFP, George AJTet al., 2011, Arginine depletion as a mechanism for the immune privilege of corneal allografts, European Journal of Immunology, Vol: 41, Pages: 2997-3005, ISSN: 1521-4141

The cornea is an immune privileged tissue. Since arginase has been found to modulate T-cell function by depleting arginine, we investigated the expression of arginase in the cornea and its possible role in immune privilege using a murine transplant model. We found that both the endothelium and epithelium of murine corneas express functional arginase I, capable of down-regulating T-cell proliferation in an in vitro culture system. The administration of the specific arginase inhibitor N-hydroxy-nor-l-Arg to recipient mice resulted in an accelerated rejection of allogeneic C57BL/6 (B6) corneal grafts. In contrast, in vivo blockade of arginase activity had no effect in altering the course of rejection of primary skin grafts that express little, if any, arginase. In addition, the inhibition of arginase did not alter systemic T-cell proliferation. These data show that arginase is functional in the cornea and contributes to the immune privilege of the eye, and that modulation of arginase contributes to graft survival.

Journal article

Leyton J, Iddon L, Perumal M, Indrevoll B, Glaser M, Robins E, George AJT, Cuthbertson A, Luthra SK, Aboagye EOet al., 2011, Targeting Somatostatin Receptors: Preclinical Evaluation of Novel F-18-Fluoroethyltriazole-Tyr(3)-Octreotate Analogs for PET, JOURNAL OF NUCLEAR MEDICINE, Vol: 52, Pages: 1441-1448, ISSN: 0161-5505

Journal article

Iddon L, Leyton J, Indrevoll B, Glaser M, Robins EG, George AJT, Cuthbertson A, Luthra SK, Aboagye EOet al., 2011, Synthesis and in vitro evaluation of [F-18]fluoroethyl triazole labelled [Tyr(3)]octreotate analogues using click chemistry, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol: 21, Pages: 3122-3127, ISSN: 0960-894X

Journal article

Zaher SS, Germain C, Fu H, Larkin DFP, George AJTet al., 2011, 3-Hydroxykynurenine Suppresses CD4(+) T-Cell Proliferation, Induces T-Regulatory-Cell Development, and Prolongs Corneal Allograft Survival, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 52, Pages: 2640-2648, ISSN: 0146-0404

Journal article

Seow WY, Yang Y-Y, George AJT, 2010, Novel Triblock Oligopeptides as Efficient Nonviral Vectors: Characterisation and Further Insights, MACROMOLECULAR RAPID COMMUNICATIONS, Vol: 31, Pages: 1170-1174, ISSN: 1022-1336

Journal article

Yang Y-Y, George AT, Kataoka K, Luo D, Wang Set al., 2010, Macromolecular Synthetic Biomaterials for Delivery of Therapeutics, MACROMOLECULAR RAPID COMMUNICATIONS, Vol: 31, Pages: 1121-1121, ISSN: 1022-1336

Journal article

Zaher SS, Larkin DFP, George AJT, 2010, Prolongation of Mouse Corneal Allograft Survival Following Systemic and Topical 3-Hydroxykynurenine (3HK) Administration, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404

Conference paper

Hansel TT, Kropshofer H, Singer T, Mitchell JA, George AJTet al., 2010, The safety and side effects of monoclonal antibodies, NATURE REVIEWS DRUG DISCOVERY, Vol: 9, Pages: 325-338, ISSN: 1474-1776

Journal article

Mouratidis PXE, George AJT, 2010, Transfection of indoleamine 2,3 dioxygenase in primary endothelial cells., Methods Mol Biol, Vol: 616, Pages: 149-159

The endothelial cell plays a central role in the control of inflammatory processes. The recruitment of inflammatory leucocytes into the blood vessels is controlled by the expression of adhesion molecules on the endothelium as well as the secretion and presentation of chemokines. Indoleamine 2,3 dioxygenase (IDO) is an enzyme that metabolises tryptophan and is known to be central in the regulation of immune responses. IDO can be expressed on endothelial cells and can alter T-cell responses to the endothelium. We show that IDO can be readily transfected in primary endothelial cells and detail a method to determine the activity of the transfected protein.

Journal article

Seow WY, Yang Y-Y, George AJT, 2009, Oligopeptide-mediated gene transfer into mouse corneal endothelial cells: expression, design optimization, uptake mechanism and nuclear localization, NUCLEIC ACIDS RESEARCH, Vol: 37, Pages: 6276-6289, ISSN: 0305-1048

Journal article

Fazekasova H, Golshayan D, Read J, Tsallios A, Tsang JY-S, Dorling A, George AJT, Lechler RI, Lombardi G, Mirenda Vet al., 2009, Regulation of Rat and Human T-Cell Immune Response by Pharmacologically Modified Dendritic Cells, TRANSPLANTATION, Vol: 87, Pages: 1617-1628, ISSN: 0041-1337

Journal article

Theoharis S, Krueger U, Tan PH, Haskard DO, Weber M, George AJTet al., 2009, Targeting gene delivery to activated vascular endothelium using anti E/P-Selectin antibody linked to PAMAM dendrimers, JOURNAL OF IMMUNOLOGICAL METHODS, Vol: 343, Pages: 79-90, ISSN: 0022-1759

Journal article

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