Imperial College London
Alternate

Emeritus ProfessorAndrewGeorge

Faculty of Medicine, Department of Surgery & Cancer

Emeritus Professor
 
 
 
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Contact

 

a.george

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Zhao:2018:10.1016/j.ebiom.2018.01.025,
author = {Zhao, H and Alam, A and Pac, Soo A and George, AJT and Ma, D},
doi = {10.1016/j.ebiom.2018.01.025},
journal = {EBioMedicine},
pages = {31--42},
title = {Ischemia-reperfusion injury reduces long term renal graft survival: mechanism and beyond},
url = {http://dx.doi.org/10.1016/j.ebiom.2018.01.025},
volume = {28},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Ischemia-reperfusion injury (IRI) during renal transplantation often initiates non-specific inflammatory responses that can result in the loss of kidney graft viability. However, the long-term consequence of IRI on renal grafts survival is uncertain. Here we review clinical evidence and laboratory studies, and elucidate the association between early IRI and later graft loss. Our critical analysis of previous publications indicates that early IRI does contribute to later graft loss through reduction of renal functional mass, graft vascular injury, and chronic hypoxia, as well as subsequent fibrosis. IRI is also known to induce kidney allograft dysfunction and acute rejection, reducing graft survival. Therefore, attempts have been made to substitute traditional preserving solutions with novel agents, yielding promising results.
AU  - Zhao,H
AU  - Alam,A
AU  - Pac,Soo A
AU  - George,AJT
AU  - Ma,D
DO  - 10.1016/j.ebiom.2018.01.025
EP  - 42
PY  - 2018///
SN  - 2352-3964
SP  - 31
TI  - Ischemia-reperfusion injury reduces long term renal graft survival: mechanism and beyond
T2  - EBioMedicine
UR  - http://dx.doi.org/10.1016/j.ebiom.2018.01.025
UR  - http://hdl.handle.net/10044/1/56746
VL  - 28
ER  -
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