Imperial College London
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Dr Athina Georgiadou

Faculty of Medicine, Department of Infectious Disease

Imperial College Research Fellow
 
 
 
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Contact

 

a.georgiadou

 
 
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Location

 

246St Mary's Research BuildingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Lee:2017:10.1101/193631,
author = {Lee, HJ and Walther, M and Georgiadou, A and Nwakanma, D and Stewart, LB and Levin, M and Otto, TD and Conway, DJ and Coin, LJ and Cunnington, AJ},
doi = {10.1101/193631},
title = {Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria},
url = {http://dx.doi.org/10.1101/193631},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - <jats:title>Abstract</jats:title><jats:p>The pathogenesis of severe <jats:italic>Plasmodium falciparum</jats:italic> malaria is incompletely understood. Since the pathogenic stage of the parasite is restricted to blood, dual RNA-sequencing of host and parasite transcripts in blood can reveal their interactions at a systemic scale. Here we identify human and parasite gene expression associated with severe disease features in Gambian children. Differences in parasite load explained up to 99% of differential expression of human genes but only a third of the differential expression of parasite genes. Co-expression analyses showed a remarkable co-regulation of host and parasite genes controlling translation, and host granulopoiesis genes uniquely co-regulated and differentially expressed in severe malaria. Our results indicate that high parasite load is the proximal stimulus for severe <jats:italic>P. falciparum</jats:italic> malaria, that there is an unappreciated role for many parasite genes in determining virulence, and hint at a molecular arms-race between host and parasite to synthesise protein products.</jats:p>
AU  - Lee,HJ
AU  - Walther,M
AU  - Georgiadou,A
AU  - Nwakanma,D
AU  - Stewart,LB
AU  - Levin,M
AU  - Otto,TD
AU  - Conway,DJ
AU  - Coin,LJ
AU  - Cunnington,AJ
DO  - 10.1101/193631
PY  - 2017///
TI  - Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria
UR  - http://dx.doi.org/10.1101/193631
ER  -
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