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@article{Morris:2021:10.1186/s13071-021-04789-0,
author = {Morris, AL and Ghani, A and Ferguson, N},
doi = {10.1186/s13071-021-04789-0},
journal = {Parasites and Vectors},
pages = {1--12},
title = {Fine-scale estimation of key life-history parameters of malaria vectors: implications for next-generation vector control technologies},
url = {http://dx.doi.org/10.1186/s13071-021-04789-0},
volume = {14},
year = {2021}
}

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TY  - JOUR
AB  - BackgroundMosquito control has the potential to significantly reduce malaria burden on a region, but to influence public health policy must also show cost-effectiveness. Gaps in our knowledge of mosquito population dynamics mean that mathematical modelling of vector control interventions have typically made simplifying assumptions about key aspects of mosquito ecology. Often, these assumptions can distort the predicted efficacy of vector control, particularly next-generation tools such as gene drive, which are highly sensitive to local mosquito dynamics.MethodsWe developed a discrete-time stochastic mathematical model of mosquito population dynamics to explore the fine-scale behaviour of egg-laying and larval density dependence on parameter estimation. The model was fitted to longitudinal mosquito population count data using particle Markov chain Monte Carlo methods.ResultsBy modelling fine-scale behaviour of egg-laying under varying density dependence scenarios we refine our life history parameter estimates, and in particular we see how model assumptions affect population growth rate (Rm), a crucial determinate of vector control efficacy.ConclusionsSubsequent application of these new parameter estimates to gene drive models show how the understanding and implementation of fine-scale processes, when deriving parameter estimates, may have a profound influence on successful vector control. The consequences of this may be of crucial interest when devising future public health policy.
AU  - Morris,AL
AU  - Ghani,A
AU  - Ferguson,N
DO  - 10.1186/s13071-021-04789-0
EP  - 12
PY  - 2021///
SN  - 1756-3305
SP  - 1
TI  - Fine-scale estimation of key life-history parameters of malaria vectors: implications for next-generation vector control technologies
T2  - Parasites and Vectors
UR  - http://dx.doi.org/10.1186/s13071-021-04789-0
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000662741400003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-021-04789-0
UR  - http://hdl.handle.net/10044/1/98363
VL  - 14
ER  -

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