Professor Angelika Gründling

Faculty of Medicine, Department of Infectious Disease

Professor of Molecular Microbiology

Contact

Location

3.21Flowers buildingSouth Kensington Campus

Summary

Angelika Gründling is a Professor in Molecular Microbiology at Imperial College London, where she started her independent research career in 2007. The research focuses onthe investigation of fundamental processes that are essential for the growth of Gram-positive bacterial pathogens. She combines genetic, biochemical and in collaborations structural approaches to provide mechanistic insight into cell wall synthesis and nucleotide signalling pathways in Staphylococcus aureus and Listeria monocytogenes.Angelika obtained her Ph.D. in Microbiology from the University of Vienna in 2000. She performed her postdoctoral training at the Harvard Medical School, where she investigated flagallar motility in the bacterial pathogen Listeria monocytogenes and at the University of Chicago, where she initiated her studies on the cell wall of S. aureus. At Imperial College London she continues her work on the bacterial cell wall and more recently on the essential signalling nucleotide c-di-AMP.

Publications

Journals

Schulz LM, Rothe P, Halbedel S, et al.Schulz LM, Rothe P, Halbedel S, Gründling A, Rismondo J close, 2022, Imbalance of peptidoglycan biosynthesis alters the cell surface charge of Listeria monocytogenes, The Cell Surface, Vol:8, ISSN:2468-2330, Pages:1-16

Nolan AC, Zeden MS, Campbell C, et al.Nolan AC, Zeden MS, Campbell C, Kviatkovski I, Urwin L, Corrigan RM, Gründling A, O’Gara JP close, 2022, Purine nucleosides interfere with c-di-AMP levels and act as adjuvants to re-sensitise MRSA to β-lactam antibiotics

Chee Wezen X, Chandran A, Eapen RS, et al.Chee Wezen X, Chandran A, Eapen RS, Waters E, Bricio-Moreno L, Tosi T, Dolan S, Millership C, Kadioglu A, Gründling A, Itzhaki LS, Welch M, Rahman T close, 2022, Structure-based discovery of lipoteichoic acid synthase inhibitors., Journal of Chemical Information and Modeling, Vol:62, ISSN:1549-9596, Pages:2586-2599

Pathania M, Tosi T, Millership C, et al.Pathania M, Tosi T, Millership C, Hoshiga F, Morgan RML, Freemont PS, Grundling A close, 2021, Structural basis for the inhibition of the Bacillus subtilis c-di-AMP cyclase CdaA by the phosphoglucomutase GlmM, Journal of Biological Chemistry, Vol:297, ISSN:0021-9258, Pages:1-15

Grundling A, Collet J-F, 2021, Editorial overview: "All in all, it is not just another brick in the wall": new concepts and mechanisms on how bacteria build their wall, Current Opinion in Microbiology, Vol:62, ISSN:1369-5274, Pages:110-113

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