ProfessorAngelikaGrundling

Faculty of Medicine, Department of Infectious Disease

Professor of Molecular Microbiology

Contact

Location

3.21Flowers buildingSouth Kensington Campus

Summary

Angelika Gründling is a Professor in Molecular Microbiology at Imperial College London, where she started her independent research career in 2007. The research focuses onthe investigation of fundamental processes that are essential for the growth of Gram-positive bacterial pathogens. She combines genetic, biochemical and in collaborations structural approaches to provide mechanistic insight into cell wall synthesis and nucleotide signalling pathways in Staphylococcus aureus and Listeria monocytogenes.Angelika obtained her Ph.D. in Microbiology from the University of Vienna in 2000. She performed her postdoctoral training at the Harvard Medical School, where she investigated flagallar motility in the bacterial pathogen Listeria monocytogenes and at the University of Chicago, where she initiated her studies on the cell wall of S. aureus. At Imperial College London she continues her work on the bacterial cell wall and more recently on the essential signalling nucleotide c-di-AMP.

Publications

Journals

Rismondo J, Gillis A, Grundling A, 2021, Modifications of cell wall polymers in Gram-positive bacteria by multi-component transmembrane glycosylation systems, Current Opinion in Microbiology, Vol:60, ISSN:1369-5274, Pages:24-33

Wu C-H, Rismondo J, Morgan RML, et al.Wu C-H, Rismondo J, Morgan RML, Shen Y, Loessner MJ, Larrouy-Maumus G, Freemont PS, Grundling A close, 2021, Bacillus subtilis YngB contributes to wall teichoic acid glucosylation and glycolipid formation during anaerobic growth, Journal of Biological Chemistry, Vol:296, ISSN:0021-9258, Pages:1-14

Rismondo J, Schulz LM, Yacoub M, et al.Rismondo J, Schulz LM, Yacoub M, Wadhawan A, Hoppert M, Dionne MS, Gründling A close, 2021, EslB is required for cell wall biosynthesis and modification in Listeria monocytogenes., Journal of Bacteriology, Vol:203, ISSN:0021-9193, Pages:1-16

Zhang K, Raju C, Zhong W, et al.Zhang K, Raju C, Zhong W, Pethe K, Gründling A, Chan-Park MB close, 2021, Cationic glycosylated block Co-β-peptide acts on the cell wall of gram-positive bacteria as anti-biofilm agents, Acs Applied Bio Materials, ISSN:2576-6422

Zhong W, Shi Z, Mahadevegowda SH, et al.Zhong W, Shi Z, Mahadevegowda SH, Liu B, Zhang K, Hui Koh C, Ruan L, Chen Y, Zeden MS, Pee CJE, Marimuthu K, Pratim De P, Tek Ng O, Zhu Y, Chi YR, Hammond PT, Yang L, Gan Y-H, Pethe K, Greenberg EP, Grundling A, Chan-Park MB close, 2020, Designer broad-spectrum polyimidazolium antibiotics, Proceedings of the National Academy of Sciences of Usa, Vol:117, ISSN:0027-8424, Pages:31376-31385

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