ProfessorAngelikaGrundling

Faculty of Medicine, Department of Infectious Disease

Professor of Molecular Microbiology

Contact

Location

3.21Flowers buildingSouth Kensington Campus

Summary

Angelika Gründling is a Professor in Molecular Microbiology at Imperial College London, where she started her independent research career in 2007. The research focuses onthe investigation of fundamental processes that are essential for the growth of Gram-positive bacterial pathogens. She combines genetic, biochemical and in collaborations structural approaches to provide mechanistic insight into cell wall synthesis and nucleotide signalling pathways in Staphylococcus aureus and Listeria monocytogenes.Angelika obtained her Ph.D. in Microbiology from the University of Vienna in 2000. She performed her postdoctoral training at the Harvard Medical School, where she investigated flagallar motility in the bacterial pathogen Listeria monocytogenes and at the University of Chicago, where she initiated her studies on the cell wall of S. aureus. At Imperial College London she continues her work on the bacterial cell wall and more recently on the essential signalling nucleotide c-di-AMP.

Publications

Journals

Schuster CF, Wiedemann DM, Kirsebom FCM, et al.Schuster CF, Wiedemann DM, Kirsebom FCM, Santiago M, Walker S, Gründling A close, 2019, High‐throughput transposon sequencing highlights the cell wall as an important barrier for osmotic stress in methicillin resistant Staphylococcus aureus and underlines a tailored response to different osmotic stressors, Molecular Microbiology, ISSN:0950-382X

Sumrall ET, Shen Y, Keller AP, et al.Sumrall ET, Shen Y, Keller AP, Rismondo J, Pavlou M, Eugster MR, Boulos S, Disson O, Thouvenot P, Kilcher S, Wollscheid B, Cabanes D, Lecuit M, Gründling A, Loessner MJ close, 2019, Phage resistance at the cost of virulence: Listeria monocytogenes serovar 4b requires galactosylated teichoic acids for InlB-mediated invasion, Plos Pathogens, Vol:15, ISSN:1553-7366

Rismondo J, Halbedel S, Grundling A, 2019, Cell shape and antibiotic resistance is maintained by the activity of multiple FtsW and RodA enzymes in Listeria monocytogenes, Mbio, Vol:10, ISSN:2150-7511, Pages:1-17

Schuster CF, Wiedemann DM, Kirsebom FCM, et al.Schuster CF, Wiedemann DM, Kirsebom FCM, Santiago M, Walker S, Gründling A close, 2019, High-throughput transposon sequencing highlights the cell wall as an important barrier for osmotic stress in methicillin resistant Staphylococcus aureus and underlines a tailored response to different osmotic stressors

Schuster C, Howard S, Grundling A, 2019, Use of the counter selectable marker PheS* for genome engineering in Staphylococcus aureus, Microbiology, Vol:165, ISSN:1350-0872, Pages:572-584

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