Summary
Angelika Gründling is a Professor in Molecular Microbiology at Imperial College London, where she started her independent research career in 2007. The research focuses onthe investigation of fundamental processes that are essential for the growth of Gram-positive bacterial pathogens. She combines genetic, biochemical and in collaborations structural approaches to provide mechanistic insight into cell wall synthesis and nucleotide signalling pathways in Staphylococcus aureus and Listeria monocytogenes.Angelika obtained her Ph.D. in Microbiology from the University of Vienna in 2000. She performed her postdoctoral training at the Harvard Medical School, where she investigated flagallar motility in the bacterial pathogen Listeria monocytogenes and at the University of Chicago, where she initiated her studies on the cell wall of S. aureus. At Imperial College London she continues her work on the bacterial cell wall and more recently on the essential signalling nucleotide c-di-AMP.
Publications
Journals
Rismondo J, Halbedel S, Grundling A, Cell shape and antibiotic resistance is maintained by the activity of multiple FtsW and RodA enzymes in Listeria monocytogenes, Mbio, ISSN:2150-7511
Schuster C, Howard S, Grundling A, 2019, Use of the counter selectable marker PheS* for genome engineering in Staphylococcus aureus, Microbiology, ISSN:1350-0872
Tosi T, Hoshiga F, Millership C, et al., 2019, Inhibition of the Staphylococcus aureus c-di-AMP cyclase DacA by direct interaction with the phosphoglucosamine mutase GlmM, Plos Pathogens, Vol:15, ISSN:1553-7366
Karinou E, Schuster C, Pazos M, et al., 2018, Inactivation of the monofunctional peptidoglycan glycosyltransferase SgtB allows Staphylococcus aureus to survive in the absence of lipoteichoic acid, Journal of Bacteriology, Vol:201, ISSN:0021-9193