Imperial College London
Alternate

Professor Alun H Davies, MA,DM,DSc,FRCS,FHEA,FEBVS,FACPh

Faculty of Medicine, Department of Surgery & Cancer

Professor of Vascular Surgery
 
 
 
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Contact

 

+44 (0)20 3311 7309a.h.davies

 
 
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Location

 

4E04 EastEast WingCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bergner:2023:10.1097/sla.0000000000004933,
author = {Bergner, R and Onida, S and Velineni, R and Spagou, K and Gohel, MS and Bouschbacher, M and Bohbot, S and Shalhoub, J and Holmes, E and Davies, AH},
doi = {10.1097/sla.0000000000004933},
journal = {Annals of Surgery},
pages = {e467--e474},
title = {Metabolic profiling reveals changes in serum predictive of venous ulcer healing},
url = {http://dx.doi.org/10.1097/sla.0000000000004933},
volume = {277},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objective: The aim of this study was to identify potential biomarkers predictive of healing or failure to heal in a population with venous leg ulceration.Summary Background Data: Venous leg ulceration presents important physical, psychological, social and financial burdens. Compression therapy is the main treatment, but it can be painful and time-consuming, with significant recurrence rates. The identification of a reliable biochemical signature with the ability to identify nonhealing ulcers has important translational applications for disease prognostication, personalized health care and the development of novel therapies.Methods: Twenty-eight patients were assessed at baseline and at 20 weeks. Untargeted metabolic profiling was performed on urine, serum, and ulcer fluid, using mass spectrometry and nuclear magnetic resonance spectroscopy.Results: A differential metabolic phenotype was identified in healing (n = 15) compared to nonhealing (n = 13) venous leg ulcer patients. Analysis of the assigned metabolites found ceramide and carnitine metabolism to be relevant pathways. In this pilot study, only serum biofluids could differentiate between healing and nonhealing patients. The ratio of carnitine to ceramide was able to differentiate between healing phenotypes with 100% sensitivity, 79% specificity, and 91% accuracy.Conclusions: This study reports a metabolic signature predictive of healing in venous leg ulceration and presents potential translational applications for disease prognostication and development of targeted therapies.
AU  - Bergner,R
AU  - Onida,S
AU  - Velineni,R
AU  - Spagou,K
AU  - Gohel,MS
AU  - Bouschbacher,M
AU  - Bohbot,S
AU  - Shalhoub,J
AU  - Holmes,E
AU  - Davies,AH
DO  - 10.1097/sla.0000000000004933
EP  - 474
PY  - 2023///
SN  - 0003-4932
SP  - 467
TI  - Metabolic profiling reveals changes in serum predictive of venous ulcer healing
T2  - Annals of Surgery
UR  - http://dx.doi.org/10.1097/sla.0000000000004933
UR  - https://journals.lww.com/annalsofsurgery/Abstract/9000/Metabolic_Profiling_Reveals_Changes_in_Serum.93544.aspx
UR  - http://hdl.handle.net/10044/1/90285
VL  - 277
ER  -
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