Imperial College London
Alternate

Professor Amin Hajitou

Faculty of Medicine, Department of Brain Sciences

Professor of Targeted Therapeutics
 
 
 
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Contact

 

+44 (0)20 7594 6546a.hajitou Website

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Vassileva:2021:10.3390/biomedicines9070811,
author = {Vassileva, V and Braga, M and Barnes, C and Przystal, J and Ashek, A and Allott, L and Brickute, D and Abrahams, J and Suwan, K and Carcaboso, AM and Hajitou, A and Aboagye, EO},
doi = {10.3390/biomedicines9070811},
journal = {Biomedicines},
pages = {1--14},
title = {Effective detection and monitoring of glioma using [18F]FPIA PET imaging},
url = {http://dx.doi.org/10.3390/biomedicines9070811},
volume = {9},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Reprogrammed cellular metabolism is a cancer hallmark. In addition to increased glycolysis, the oxidation of acetate in the citric acid cycle is another common metabolic phenotype. We have recently developed a novel fluorine-18-labelled trimethylacetate-based radiotracer, [18F]fluoro-pivalic acid ([18F]FPIA), for imaging the transcellular flux of short-chain fatty acids, and investigated whether this radiotracer can be used for the detection of glioma growth. Methods: We evaluated the potential of [18F]FPIA PET to monitor tumor growth in orthotopic patient-derived (HSJD-GBM-001) and cell line-derived (U87, LN229) glioma xenografts, and also included [18F]FDG PET for comparison. We assessed proliferation (Ki-67) and the expression of lipid metabolism and transport proteins (CPT1, SLC22A2, SLC22A5, SLC25A20) by immunohistochemistry, along with etomoxir treatment to provide insights into [18F]FPIA uptake. Results: Longitudinal PET imaging showed gradual increase in [18F]FPIA uptake in orthotopic glioma models with disease progression (p < 0.0001), and high tumor-to-brain contrast compared to [18F]FDG (p < 0.0001). [18F]FPIA uptake correlated positively with Ki-67 (p < 0.01), SLC22A5 (p < 0.001) and SLC25A20 (p = 0.001), and negatively with CPT1 (p < 0.01) and SLC22A2 (p < 0.01). Etomoxir reduced [18F]FPIA uptake, which correlated with decreased Ki-67 (p < 0.05). Conclusions: Our findings support the use of [18F]FPIA PET for the detection and longitudinal monitoring of glioma, showing a positive correlation with tumor proliferation, and suggest transcellular flux-mediated radiotracer uptake.
AU  - Vassileva,V
AU  - Braga,M
AU  - Barnes,C
AU  - Przystal,J
AU  - Ashek,A
AU  - Allott,L
AU  - Brickute,D
AU  - Abrahams,J
AU  - Suwan,K
AU  - Carcaboso,AM
AU  - Hajitou,A
AU  - Aboagye,EO
DO  - 10.3390/biomedicines9070811
EP  - 14
PY  - 2021///
SN  - 2227-9059
SP  - 1
TI  - Effective detection and monitoring of glioma using [18F]FPIA PET imaging
T2  - Biomedicines
UR  - http://dx.doi.org/10.3390/biomedicines9070811
UR  - https://www.mdpi.com/2227-9059/9/7/811
UR  - http://hdl.handle.net/10044/1/90403
VL  - 9
ER  -
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