Imperial College London

DrAliceHalliday

Faculty of MedicineNational Heart & Lung Institute

Research Associate
 
 
 
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Contact

 

a.halliday

 
 
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Location

 

252Medical SchoolSt Mary's Campus

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Summary

 

Summary

Dr Alice Halliday received her BSc in Microbiology from the University of Manchester in 2008. She subsequently worked as a research assistant on an NHS-funded project exploring health care needs in relation to immunisation uptake in Manchester. She then moved back to laboratory science, gaining a PhD from the Liverpool School of Tropical Medicine (LSTM) exploring the immune responses to Leishmania infection. Her first postdoc, also at LSTM, involved the development of models of Onchocerciasis for drug screening, both in the UK and in Cameroon.

In 2014, Dr Halliday moved to Imperial College where her work has been focused on exploring cellular immune responses in Tuberculosis, with a particular interest in the development of new diagnostic tools. By interogating immune responses to Mycobacterium tuberculosis antigens using flow cytometry, it has been shown that it is possible to differentiate between different stages of Tuberculosis infection in humans. Dr Halliday aims to validate this approach using large biobanks of samples, taken from patients with the full spectrum of active and latent Tuberculosis infection, with the aim of developing improved diagnostic tests. 

Click here for Alice's blog post about the making of an animation film about latent Tuberculosis.

Publications

Journals

Reuschl A-K, Edwards MR, Parker R, et al., 2017, Innate activation of human primary epithelial cells broadens the host response to Mycobacterium tuberculosis in the airways, Plos Pathogens, Vol:13, ISSN:1553-7366

Halliday A, Whitworth H, Kottoor SH, et al., 2017, Stratification of Latent Mycobacterium tuberculosis Infection by Cellular Immune Profiling, Journal of Infectious Diseases, Vol:215, ISSN:0022-1899, Pages:1480-1487

Halliday A, Turner JD, GuimarĂ£es A, et al., 2016, The TLR2/6 ligand PAM2CSK4 is a Th2 polarizing adjuvant in Leishmania major and Brugia malayi murine vaccine models., Parasit Vectors, Vol:9

Halliday A, Bates PA, Chance ML, et al., 2016, Toll-like receptor 2 (TLR2) plays a role in controlling cutaneous leishmaniasis in vivo, but does not require activation by parasite lipophosphoglycan, Parasites & Vectors, Vol:9, ISSN:1756-3305

Halliday A, Guimaraes AF, Tyrer HE, et al., 2014, A murine macrofilaricide pre-clinical screening model for onchocerciasis and lymphatic filariasis., Parasit Vectors, Vol:7

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