Dr Alice Halliday received her BSc in Microbiology from the University of Manchester in 2008. She subsequently worked as a research assistant on an NHS-funded project exploring health care needs in relation to immunisation uptake in Manchester. She then moved back to laboratory science, gaining a PhD from the Liverpool School of Tropical Medicine (LSTM) exploring the immune responses to Leishmania infection. Her first postdoc, also at LSTM, involved the development of models of Onchocerciasis for drug screening, both in the UK and in Cameroon.
In 2014, Dr Halliday moved to Imperial College where her work has been focused on exploring cellular immune responses in Tuberculosis, with a particular interest in the development of new diagnostic tools. By interogating immune responses to Mycobacterium tuberculosis antigens using flow cytometry, it has been shown that it is possible to differentiate between different stages of Tuberculosis infection in humans. Dr Halliday aims to validate this approach using large biobanks of samples, taken from patients with the full spectrum of active and latent Tuberculosis infection, with the aim of developing improved diagnostic tests.
et al., 2018, Interleukin-4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3-dependent eosinophilia, Plos Pathogens, Vol:14, ISSN:1553-7366
et al., 2017, Innate activation of human primary epithelial cells broadens the host response to Mycobacterium tuberculosis in the airways, Plos Pathogens, Vol:13, ISSN:1553-7366
et al., 2017, Stratification of Latent Mycobacterium tuberculosis Infection by Cellular Immune Profiling, Journal of Infectious Diseases, Vol:215, ISSN:0022-1899, Pages:1480-1487
et al., 2016, Toll-like receptor 2 (TLR2) plays a role in controlling cutaneous leishmaniasis in vivo, but does not require activation by parasite lipophosphoglycan, Parasites & Vectors, Vol:9, ISSN:1756-3305
et al., 2016, The TLR2/6 ligand PAM2CSK4 is a Th2 polarizing adjuvant in Leishmania major and Brugia malayi murine vaccine models, Parasites & Vectors, Vol:9, ISSN:1756-3305