Imperial College London
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ProfessorAdamHampshire

Faculty of Medicine, Department of Brain Sciences

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 7993a.hampshire

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Stewart:2020:10.1002/aur.2277,
author = {Stewart, GR and Corbett, A and Ballard, C and Creese, B and Aarsland, D and Hampshire, A and Charlton, RA and Happé, F},
doi = {10.1002/aur.2277},
journal = {Autism Res},
pages = {641--654},
title = {The Mental and Physical Health of Older Adults With a Genetic Predisposition for Autism.},
url = {http://dx.doi.org/10.1002/aur.2277},
volume = {13},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Autism commonly aggregates in families, with twin studies estimating heritability to be around 80%. Subclinical autism-like characteristics have also been found at elevated rates in relatives of autistic probands. Physical and psychiatric conditions have been reported at elevated rates in autistic children and adults, and also in their relatives. However, to date, there has been no exploration of how aging may affect this pattern. This study examined cross-sectional data from the ongoing online PROTECT study. A total of 20,220 adults aged 50 years and older reported whether they have an autistic first-degree relative. In total, 739 older adults reported having an autistic first-degree relative (AFDR group) and 11,666 were identified as having no family history of any neurodevelopmental disorder (NFD group). The AFDR group demonstrated significantly higher frequencies of self-reported psychiatric diagnoses and a greater total number of co-occurring psychiatric diagnoses than the NFD group. Furthermore, the AFDR group reported elevated current self-report symptoms of depression, anxiety, traumatic experience, and post-traumatic stress than the NFD group. By contrast, few differences between AFDR and NFD groups were observed in physical health conditions, and no differences were observed in the total number of co-occurring physical health diagnoses. These findings suggest that adults who have an AFDR may be at greater risk of poor mental, but not physical, health in later life. Older adults with autistic relatives may benefit from close monitoring to mitigate this susceptibility and to provide timely intervention. Autism Res 2020, 13: 641-654. © 2020 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: Children and adults with an autistic relative have been found to experience more psychiatric difficulties than those with no family links to autism. However, a few studies have e
AU  - Stewart,GR
AU  - Corbett,A
AU  - Ballard,C
AU  - Creese,B
AU  - Aarsland,D
AU  - Hampshire,A
AU  - Charlton,RA
AU  - Happé,F
DO  - 10.1002/aur.2277
EP  - 654
PY  - 2020///
SP  - 641
TI  - The Mental and Physical Health of Older Adults With a Genetic Predisposition for Autism.
T2  - Autism Res
UR  - http://dx.doi.org/10.1002/aur.2277
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32045138
VL  - 13
ER  -
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