Summary
Qualification and Personal History
- PhD in Molecular Endocrinology 2002 (with Distinction), University Western Australia (Group of Prof. Karin Eidne)
- Postdoctoral work at University of California San Francisco) (2002-2007) (Group of Prof. Mark von Zastrow)
- Joined Imperial College London in August 2007 as a Research Team Leader (G protein-coupled receptor (GPCR) Signalling Group) and Lecturer
Research Interests
Understanding fundamental cell biological mechanisms regulating G protein-coupled receptor (GPCR) signal transduction and applying these mechanisms to understand the role of this superfamily of receptors in diverse physiological and pathophysiological systems.
Current Projects
- Molecular mechanisms regulating signal activation of the gonadotrophin hormone receptors (luteinizing hormone and follicle stimulating hormone) via membrane trafficking
- Role of GPCR dimerization and oligomerization on receptor activity via super-resolution imaging
- Role of prostaglandin and oxytocin receptor action in the pregnant human myometrium and the signalling pathways involved in labour and pre-term labour
- Human chorionic gonadotrophin hormone action in human endometrium and reprogramming of receptor activity in recurrent pregnancy loss
- Molecular regulation of free fatty acid receptor (FFA2 and FFA4) signalling in intestinal and brown adipocyte function
This work is funded by the Wellcome Trust, BBSRC and Genesis Research Trust.
Selected Publications
Journal Articles
West C, Hanyaloglu AC, 2015, Minireview: Spatial Programming of G Protein-Coupled Receptor Activity: Decoding Signaling in Health and Disease., Molecular Endocrinology, Vol:29, ISSN:1944-9917, Pages:1095-1106
Jonas KC, Fanelli F, Huhtaniemi IT, et al., 2014, Single molecule analysis of functionally asymmetric G protein-coupled receptor (GPCR) oligomers reveals diverse spatial and structural assemblies, Journal of Biological Chemistry, Vol:290, ISSN:1083-351X, Pages:3875-3892
Sposini S, Caltabiano G, Hanyaloglu AC, et al., 2014, Identification of transmembrane domains that regulate spatial arrangements and activity of prokineticin receptor 2 dimers, Molecular and Cellular Endocrinology, Vol:399, ISSN:1872-8057, Pages:362-372
Jean-Alphonse F, Bowersox S, Chen S, et al., 2013, Spatially restricted G protein-coupled receptor signaling via divergent endocytic compartments, Journal of Biological Chemistry, Vol:289, ISSN:1083-351X
Kandola MK, Sykes L, Lee YS, et al., 2013, EP2 Receptor Activates Dual G Protein Signaling Pathways that Mediate Contrasting Proinflammatory and Relaxatory Responses in Term Pregnant Human Myometrium, Endocrinology, Vol:Epub ahead of print
Jonas KC, Rivero-Mueller A, Huhtaniemi IT, et al., 2013, G Protein-Coupled Receptor Transactivation: From Molecules to Mice, Methods in Cell Biology, Vol:117, ISSN:0091-679X, Pages:433-450
Hanyaloglu AC, von Zastrow M, 2008, Regulation of GPCRs by Membrane Trafficking and Its Potential Implications, Annual Review of Pharmacology and Toxicology, Vol:Epub ahead of print
Chapters
Jonas KC, Huhtaniemi I, Hanyaloglu AC, 2016, Single-molecule resolution of G protein-coupled receptor (GPCR) complexes, G PROTEIN-COUPLED RECEPTORS: SIGNALING, TRAFFICKING AND REGULATION, Editor(s): Shukla, ELSEVIER ACADEMIC PRESS INC, Pages:55-72, ISBN:978-0-12-803595-5