Imperial College London
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ProfessorAylinHanyaloglu

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor in Molecular Medicine
 
 
 
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Contact

 

+44 (0)20 7594 2128a.hanyaloglu Website

 
 
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Assistant

 

Miss Kiran Dosanjh +44 (0)20 7594 2176

 
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Location

 

2009Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sposini:2018:10.1007/978-3-319-96704-2_10,
author = {Sposini, S and Hanyaloglu, AC},
doi = {10.1007/978-3-319-96704-2_10},
journal = {Prog Mol Subcell Biol},
pages = {273--299},
title = {Evolving View of Membrane Trafficking and Signaling Systems for G Protein-Coupled Receptors.},
url = {http://dx.doi.org/10.1007/978-3-319-96704-2_10},
volume = {57},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The G protein-coupled receptor (GPCR) superfamily activates complex signal pathways, yet untangling these signaling systems to understand how specificity in receptor signaling pathways is achieved, has been a challenging question. The roles of membrane trafficking in GPCR signal regulation has undergone a recent paradigm shift, from a mechanism that programs the plasma membrane G protein signaling profile to providing distinct signaling platforms critical for specifying receptor function in vivo. In this chapter, we discuss this evolution of our understanding in the endocytic trafficking systems employed by GPCRs, and how such systems play a deeply integrated role with signaling. We describe recent studies that suggest that the endomembrane compartment can provide a mechanism to both specify, and yet also diversify, GPCR signal transduction. These new evolving models could aid mechanistic understanding of complex disease and provide novel therapeutic avenues.
AU  - Sposini,S
AU  - Hanyaloglu,AC
DO  - 10.1007/978-3-319-96704-2_10
EP  - 299
PY  - 2018///
SN  - 0079-6484
SP  - 273
TI  - Evolving View of Membrane Trafficking and Signaling Systems for G Protein-Coupled Receptors.
T2  - Prog Mol Subcell Biol
UR  - http://dx.doi.org/10.1007/978-3-319-96704-2_10
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30097779
VL  - 57
ER  -
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