Imperial College London
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ProfessorAylinHanyaloglu

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor in Molecular Medicine
 
 
 
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Contact

 

+44 (0)20 7594 2128a.hanyaloglu Website

 
 
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Assistant

 

Miss Kiran Dosanjh +44 (0)20 7594 2176

 
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Location

 

2009Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Casarini:2020:10.1016/j.isci.2020.101812,
author = {Casarini, L and Lazzaretti, C and Paradiso, E and Limoncella, S and Riccetti, L and Sperduti, S and Melli, B and Marcozzi, S and Anzivino, C and Sayers, NS and Czapinski, J and Brigante, G and Potì, F and La, Marca A and De, Pascali F and Reiter, E and Falbo, A and Daolio, J and Villani, MT and Lispi, M and Orlando, G and Klinger, FG and Fanelli, F and Rivero-Müller, A and Hanyaloglu, AC and Simoni, M},
doi = {10.1016/j.isci.2020.101812},
journal = {iScience},
title = {Membrane Estrogen Receptor (GPER) and Follicle-Stimulating Hormone Receptor (FSHR) heteromeric complexes promote human ovarian follicle survival},
url = {http://dx.doi.org/10.1016/j.isci.2020.101812},
volume = {23},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Classically, follicle-stimulating hormone receptor (FSHR)-driven cAMP-mediated signaling boosts human ovarian follicle growth and oocyte maturation. However, contradicting in vitro data suggest a different view on physiological significance of FSHR-mediated cAMP signaling. We found that the G-protein-coupled estrogen receptor (GPER) heteromerizes with FSHR, reprogramming cAMP/death signals into proliferative stimuli fundamental for sustaining oocyte survival. In human granulosa cells, survival signals are missing at high FSHR:GPER ratio, which negatively impacts follicle maturation and strongly correlates with preferential Gαs protein/cAMP-pathway coupling and FSH responsiveness of patients undergoing controlled ovarian stimulation. In contrast, FSHR/GPER heteromers triggered anti-apoptotic/proliferative FSH signaling delivered via the Gβγ dimer, whereas impairment of heteromer formation or GPER knockdown enhanced the FSH-dependent cell death and steroidogenesis. Therefore, our findings indicate how oocyte maturation depends on the capability of GPER to shape FSHR selective signals, indicating hormone receptor heteromers may be a marker of cell proliferation.
AU  - Casarini,L
AU  - Lazzaretti,C
AU  - Paradiso,E
AU  - Limoncella,S
AU  - Riccetti,L
AU  - Sperduti,S
AU  - Melli,B
AU  - Marcozzi,S
AU  - Anzivino,C
AU  - Sayers,NS
AU  - Czapinski,J
AU  - Brigante,G
AU  - Potì,F
AU  - La,Marca A
AU  - De,Pascali F
AU  - Reiter,E
AU  - Falbo,A
AU  - Daolio,J
AU  - Villani,MT
AU  - Lispi,M
AU  - Orlando,G
AU  - Klinger,FG
AU  - Fanelli,F
AU  - Rivero-Müller,A
AU  - Hanyaloglu,AC
AU  - Simoni,M
DO  - 10.1016/j.isci.2020.101812
PY  - 2020///
SN  - 2589-0042
TI  - Membrane Estrogen Receptor (GPER) and Follicle-Stimulating Hormone Receptor (FSHR) heteromeric complexes promote human ovarian follicle survival
T2  - iScience
UR  - http://dx.doi.org/10.1016/j.isci.2020.101812
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33299978
UR  - http://hdl.handle.net/10044/1/85622
VL  - 23
ER  -
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