Imperial College London

ProfessorAlunHughes

Faculty of MedicineNational Heart & Lung Institute

Visiting Professor
 
 
 
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Contact

 

a.hughes Website

 
 
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Assistant

 

Mrs Kim Cyrus +44 (0)20 7594 6047

 
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Location

 

59/61 North Wharf RoadSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

1219 results found

Al Saikhan L, Park C, Tillin T, Lloyd G, Mayet J, Chaturvedi N, Hughes ADet al., 2022, Relationship Between Image Quality and Bias in 3D Echocardiographic Measures: Data From the SABRE (Southall and Brent Revisited) Study., J Am Heart Assoc, Vol: 11

Background Image-quality (IQ) compromises left ventricle assessment by 3-dimensional echocardiography (3DE). Sicker/frailer patients often have suboptimal IQ, and therefore observed associations may be biased by IQ. We investigated its effect in an observational study of older people and when IQ was modified experimentally in healthy volunteers. Methods and Results 3DE feasibility by IQ was assessed in 1294 individuals who attended the second wave of the Southall and Brent Revisited study and was compared with 2-dimensional (2D)-echocardiography feasibility in 147 individuals. Upon successful analysis, means of ejection fraction (3D-EF) and global longitudinal strain (3D-GLS) (plus 2D-EF) were compared in individuals with poor versus good IQ. In 2 studies of healthy participants, 3DE-IQ was impaired by (1) intentionally poor echocardiographic technique, and (2) use of a sheet of ultrasound-attenuating material (neoprene rubber; 2-4 mm). The feasibility was 41% (529/1294) for 3DE versus 61% (89/147) for 2D-EF, P<0.0001. Among acceptable images (n=529), good IQ by the 2015 American Society of Echocardiography/European Association of Cardiovascular Imaging criteria was 33.6% (178/529) and 71.3% (377/529) for 3D-EF and 3D-GLS, respectively. Individuals with poor IQ had lower 3D-EF and 3D-GLS (absolute) than those with good IQ (3D-EF: 52.8±6.0% versus 55.7±5.7%, Mean-Δ -2.9 [-3.9, 1.8]; 3D-GLS: 18.6±3.2% versus 19.2±2.9%, Mean-Δ -0.6 [-1.1, 0.0]). In 2 experimental models of poor IQ (n=36 for both), mean differences were (-2.6 to -3.2) for 3D-EF and (-1.2 to -2.0) for 3D-GLS. Similar findings were found for other 3DE left ventricle volumes and strain parameters. Conclusions 3DE parameters have low feasibility and values are systematically lower in individuals with poor IQ. Although 3D-EF and 3D-GLS have potential advantages over conventional echocardiography, further technical improvements are required to improve the utilit

Journal article

Wielgoszewska B, Maddock J, Green MJ, Di Gessa G, Parsons S, Griffith GJ, Croft J, Stevenson AJ, Booth C, Silverwood RJ, Bann D, Patalay P, Hughes AD, Chaturvedi N, Howe LD, Fitzsimons E, Katikireddi SV, Ploubidis GBet al., 2022, The UK Coronavirus Job Retention Scheme and diet, physical activity, and sleep during the COVID-19 pandemic: evidence from eight longitudinal population surveys, BMC MEDICINE, Vol: 20, ISSN: 1741-7015

Journal article

Webber M, Falconer D, AlFarih M, Joy G, Chan F, Davie C, Hamill Howes L, Wong A, Rapala A, Bhuva A, Davies RH, Morton C, Aguado-Sierra J, Vazquez M, Tao X, Krausz G, Tanackovic S, Guger C, Xue H, Kellman P, Pierce I, Schott J, Hardy R, Chaturvedi N, Rudy Y, Moon JC, Lambiase PD, Orini M, Hughes AD, Captur Get al., 2022, Study protocol: MyoFit46-the cardiac sub-study of the MRC National Survey of Health and Development, BMC CARDIOVASCULAR DISORDERS, Vol: 22, ISSN: 1471-2261

Journal article

Anbar R, Sultan SR, Al Saikhan L, Alkharaiji M, Chaturvedi N, Hardy R, Richards M, Hughes Aet al., 2022, Is carotid artery atherosclerosis associated with poor cognitive function assessed using the Mini-Mental State Examination? A systematic review and meta-analysis, BMJ OPEN, Vol: 12, ISSN: 2044-6055

Journal article

Fatih N, Chaturvedi N, Lane CA, Parker TD, Lu K, Cash DM, Malone IB, Silverwood R, Wong A, Barnes J, Sudre CH, Richards M, Fox NC, Schott JM, Hughes A, James S-Net al., 2022, Sex-related differences in whole brain volumes at age 70 in association with hyperglycemia during adult life., Neurobiol Aging, Vol: 112, Pages: 161-169

Longitudinal studies of the relationship between hyperglycemia and brain health are rare and there is limited information on sex differences in associations. We investigated whether glycosylated hemoglobin (HbA1c) measured at ages of 53, 60-64 and 69 years, and cumulative glycemic index (CGI), a measure of cumulative glycemic burden, were associated with metrics of brain health in later life. Participants were from Insight 46, a substudy of the Medical Research Council National Survey of Health and Development (NSHD) who undertook volumetric MRI, florbetapir amyloid-PET imaging and cognitive assessments at ages of 69-71. Analyses were performed using linear and logistic regression as appropriate, with adjustment for potential confounders. We observed a sex interaction between HbA1c and whole brain volume (WBV) at all 3 time points. Following stratification of our sample, we observed that HbA1c at all ages, and CGI were positively associated with lower WBV exclusively in females. HbA1c (or CGI) was not associated with amyloid status, white matter hyperintensities (WMHs), hippocampal volumes (HV) or cognitive outcomes in either sex. Higher HbA1c in adulthood is associated with smaller WBV at 69-71 years in females but not in males. This suggests that there may be preferential target organ damage in the brain for females with hyperglycemia.

Journal article

Palombo C, Kozakova M, Morizzo C, Losso L, Pagani M, Salvi P, Parker KH, Hughes ADet al., 2022, Carotid Reservoir Pressure Decrease After Prolonged Head Down Tilt Bed Rest in Young Healthy Subjects Is Associated With Reduction in Left Ventricular Ejection Time and Diastolic Length, FRONTIERS IN PHYSIOLOGY, Vol: 13

Journal article

Chiesa ST, Charakida M, Georgiopoulos G, Roberts JD, Stafford SJ, Park C, Mykkanen J, Kahonen M, Lehtimaki T, Ala-Korpela M, Raitakari O, Pietiainen M, Pussinen P, Muthurangu V, Hughes AD, Sattar N, Timpson NJ, Deanfield JEet al., 2022, Glycoprotein Acetyls: A Novel Inflammatory Biomarker of Early Cardiovascular Risk in the Young, JOURNAL OF THE AMERICAN HEART ASSOCIATION, Vol: 11

Journal article

Gu B, Huang Y, Manchester E, Hughes A, Thom S, Chen R, Xu XYet al., 2022, Multiphysics modelling and simulation of thrombolysis via activated platelet-targeted nanomedicine, Pharmaceutical Research, Vol: 39, Pages: 41-56, ISSN: 0724-8741

Purpose:This study establishes a multiphysics simulation platform for both conventional and targeted thrombolysis using tissue plasminogen activator (tPA). Based on our computational results, the effects of therapeutic parameters on the dynamics of thrombolysis and the risk of side effects are investigated.Methods:The model extends our previously developed one-dimensional(1D) mathematical models for fibrinolysis by incorporating targeted thrombolysis. It consists of two parts: (i) a coupled mathematical model of systemic pharmacokinetics (PK) and pharmacodynamics (PD) and local PD in a 1D occluded artery, and (ii) a mechanistic model for a targeted thrombolytic system via activated platelet-targeted tPA-loaded nanovesicles (tPA-NV), with model parameters derived from our in vitro experiments. A total of 16 therapeutic scenarios are simulated by varying the clot location and composition as well as the dosing regimen with free tPA or tPA-NV.Results:Our simulation results indicate that tPA-NV offers several advantages over free tPA for thrombolysis. It reduces systemic exposure of tPA, thereby minimising the risk of bleeding complications. Simulations with different tPA-NV doses reveal that tPA-NV at 10% of the recommended dose can be as effective as the standard regimen with the full recommended dose of free tPA, demonstrating the potential of our tPA-NV as a new thrombolytic strategy with a reduced tPA dose. Moreover, faster recanalisation can be achieved with tPA-NV, especially for platelet-rich(or fibrin-poor) clots.Conclusions:Our simulation platform for thrombolysis with well-tuned model parameters can be used to evaluate and optimise treatment regimens of existing and new thrombolytic therapies via benefit/risk assessment under various therapeutic scenarios.

Journal article

Hughes AD, Eastwood SV, Tillin T, Chaturvedi Net al., 2022, Antihypertensive Medication Use and Its Effects on Blood Pressure and Haemodynamics in a Tri-ethnic Population Cohort: Southall and Brent Revisited (SABRE), FRONTIERS IN CARDIOVASCULAR MEDICINE, Vol: 8, ISSN: 2297-055X

Journal article

Bann D, Villadsen A, Maddock J, Hughes A, Ploubidis GB, Silverwood R, Patalay Pet al., 2021, Changes in the behavioural determinants of health during the COVID-19 pandemic: gender, socioeconomic and ethnic inequalities in five British cohort studies, JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, Vol: 75, Pages: 1136-1142, ISSN: 0143-005X

Journal article

Swadling L, Diniz MO, Schmidt NM, Amin OE, Chandran A, Shaw E, Pade C, Gibbons JM, Le Bert N, Tan AT, Jeffery-Smith A, Tan CCS, Tham CYL, Kucykowicz S, Aidoo-Micah G, Rosenheim J, Davies J, Johnson M, Jensen MP, Joy G, McCoy LE, Valdes AM, Chain BM, Goldblatt D, Altmann DM, Boyton RJ, Manisty C, Treibel TA, Moon JC, COVIDsortium investigators, Dorp LV, Balloux F, McKnight Á, Noursadeghi M, Bertoletti A, Maini MKet al., 2021, Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2, Nature, Vol: 601, Pages: 110-117, ISSN: 0028-0836

Individuals with potential exposure to SARS-CoV-2 do not necessarily develop PCR or antibody positivity, suggesting some may clear sub-clinical infection before seroconversion. T-cells can contribute to the rapid clearance of SARS-CoV-2 and other coronavirus infections1-3. We hypothesised that pre-existing memory T-cell responses, with cross-protective potential against SARS-CoV-24-11, would expand in vivo to support rapid viral control, aborting infection. We measured SARS-CoV-2-reactive T-cells, including those against the early transcribed replication transcription complex (RTC)12,13, in intensively monitored healthcare workers (HCW) remaining repeatedly negative by PCR, antibody binding, and neutralisation (seronegative HCW, SN-HCW). SN-HCW had stronger, more multispecific memory T-cells than an unexposed pre-pandemic cohort, and more frequently directed against the RTC than the structural protein-dominated responses seen post-detectable infection (matched concurrent cohort). SN-HCW with the strongest RTC-specific T-cells had an increase in IFI27, a robust early innate signature of SARS-CoV-214, suggesting abortive infection. RNA-polymerase within RTC was the largest region of high sequence conservation across human seasonal coronaviruses (HCoV) and SARS-CoV-2 clades. RNA-polymerase was preferentially targeted (amongst regions tested) by T-cells from pre-pandemic cohorts and SN-HCW. RTC epitope-specific T-cells cross-recognising HCoV variants were identified in SN-HCW. Enriched pre-existing RNA-polymerase-specific T-cells expanded in vivo to preferentially accumulate in the memory response after putative abortive compared to overt SARS-CoV-2 infection. Our data highlight RTC-specific T-cells as targets for vaccines against endemic and emerging Coronaviridae.

Journal article

Al Saikhan L, Alobaida M, Bhuva A, Chaturvedi N, Heasman J, Hughes AD, Jones S, Eastwood S, Manisty C, March K, Ghosh AK, Mayet J, Oguntade A, Tillin T, Williams S, Wright A, Park Cet al., 2021, Imaging Protocol, Feasibility, and Reproducibility of Cardiovascular Phenotyping in a Large Tri-Ethnic Population-Based Study of Older People: The Southall and Brent Revisited (SABRE) Study (vol 7,591946,2020), FRONTIERS IN CARDIOVASCULAR MEDICINE, Vol: 8, ISSN: 2297-055X

Journal article

Seraphim A, Knott KD, Menacho K, Augusto JB, Davies R, Pierce I, Joy G, Bhuva AN, Xue H, Treibel TA, Cooper JA, Petersen SE, Fontana M, Hughes AD, Moon JC, Manisty C, Kellman Pet al., 2021, Prognostic Value of Pulmonary Transit Time and Pulmonary Blood Volume Estimation Using Myocardial Perfusion CMR, JACC-CARDIOVASCULAR IMAGING, Vol: 14, Pages: 2107-2119, ISSN: 1936-878X

Journal article

Fornasiero M, Pierce I, Webber M, Keenan KE, Stupic KF, Bruehl R, Ittermann B, Pang W, Hughes AD, Nezafat R, Kellman P, Moon JC, Captur Get al., 2021, A MEDICAL DEVICE-GRADE T2 PHANTOM FOR QUALITY ASSURANCE OF INFLAMMATION IMAGING BY CMR, Annual Meeting of the British-Society-of-Cardiovascular-Magnetic-Resonance (BSCMR), Publisher: BMJ PUBLISHING GROUP, Pages: A9-A10, ISSN: 1355-6037

Conference paper

Webber M, Joy G, Falconer D, Tao X, Pierce I, Moon JC, Hughes AD, Lambiase PD, Rudy Y, Orini M, Captur Get al., 2021, MYOCARDIAL INFLAMMATION AND DIFFUSE FIBROSIS UNDERPIN THE ELECTROPHYSIOLOGICAL DERANGEMENTS OF THE AGEING HUMAN HEART-A CMR-ECGI STUDY, Annual Meeting of the British-Society-of-Cardiovascular-Magnetic-Resonance (BSCMR), Publisher: BMJ PUBLISHING GROUP, Pages: A10-A11, ISSN: 1355-6037

Conference paper

Gordillo-Maranon M, Zwierzyna M, Charoen P, Drenos F, Chopade S, Shah T, Engmann J, Chaturvedi N, Papacosta O, Wannamethee G, Wong A, Sofat R, Kivimaki M, Price JF, Hughes AD, Gaunt TR, Lawlor DA, Gaulton A, Hingorani AD, Schmidt AF, Finan Cet al., 2021, Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics, NATURE COMMUNICATIONS, Vol: 12

Journal article

Farmaki A-E, Garfield V, Eastwood SV, Farmer RE, Mathur R, Giannakopoulou O, Patalay P, Kuchenbaecker K, Sattar N, Hughes A, Bhaskaran K, Smeeth L, Chaturvedi Net al., 2021, Type 2 diabetes risks and determinants in second-generation migrants and mixed ethnicity people of South Asian and African Caribbean descent in the UK, DIABETOLOGIA, Vol: 65, Pages: 113-127, ISSN: 0012-186X

Journal article

Al Saikhan L, Park C, Tillin T, Williams S, Jones S, Manisty C, Mayet J, Chaturvedi N, Hughes Aet al., 2021, Myocardial strain by 3D-speckle tracking echocardiography predicts long-term risk of cardiovascular morbidity and mortality in the general population: the Southall And Brent Revisited (SABRE) study, Publisher: OXFORD UNIV PRESS, Pages: 67-67, ISSN: 0195-668X

Conference paper

Ratneswaren A, Hadjiloizou N, Ahmad Y, Sen S, Maliq I, Parker K, Francis D, Hughes AD, Davies JE, Mayet Jet al., 2021, Coronary haemodynamics associated with left ventricular hypertrophy in aortic stenosis and hypertension, Publisher: OXFORD UNIV PRESS, Pages: 1728-1728, ISSN: 0195-668X

Conference paper

Ratneswaren A, Shah ASV, Thom SA, Sharp ASP, Francis DF, Stanton AV, Poulter NR, Sever PS, Hughes AD, Mayet Jet al., 2021, Tissue Doppler E prime velocity and E/E prime predict 19-year cardiovascular mortality in hypertension, Publisher: OXFORD UNIV PRESS, Pages: 2336-2336, ISSN: 0195-668X

Conference paper

Topriceanu C-C, Wong A, Moon JC, Hughes AD, Chaturvedi N, Conti G, Bann D, Patalay P, Captur Get al., 2021, Impact of lockdown on key workers: findings from the COVID-19 survey in four UK national longitudinal studies, JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, Vol: 75, Pages: 955-962, ISSN: 0143-005X

Journal article

Topriceanu C, Moon JC, Hardy R, Hughes AD, Captur Get al., 2021, Childhood bradycardia associates with atrioventricular conduction defects in older age: a longitudinal birth cohort study, EUROPEAN HEART JOURNAL, Vol: 42, Pages: 2398-2398, ISSN: 0195-668X

Journal article

Schmidt AF, Hunt NB, Gordillo-Maranon M, Charoen P, Drenos F, Kivimaki M, Lawlor DA, Giambartolomei C, Papacosta O, Chaturvedi N, Bis JC, O'Donnell CJ, Wannamethee G, Wong A, Price JF, Hughes AD, Gaunt TR, Franceschini N, Mook-Kanamori DO, Zwierzyna M, Sofat R, Hingorani AD, Finan Cet al., 2021, Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease, NATURE COMMUNICATIONS, Vol: 12

Journal article

Patel KP, Scully PR, Nitsche C, Kammerlander AA, Joy G, Thornton G, Hughes R, Williams S, Tillin T, Captur G, Chacko L, Kelion A, Sabharwal N, Newton JD, Kennon S, Ozkor M, Mullen M, Hawkins PN, Gillmore JD, Menezes L, Pugliese F, Hughes AD, Fontana M, Lloyd G, Treibel TA, Mascherbauer J, Moon JCet al., 2021, Impact of afterload and infiltration on coexisting aortic stenosis and transthyretin amyloidosis, HEART, Vol: 108, Pages: 67-72, ISSN: 1355-6037

Journal article

Clayton G, Howe L, Parks C, Leyland K, Hughes A, Fraser Aet al., 2021, The effect of pregnancy on cardiovascular health in early adulthood: a difference in difference analysis, INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, Vol: 50, ISSN: 0300-5771

Journal article

Su J, Simonsen U, Mellemkjaer S, Howard LS, Manisty C, Hughes ADet al., 2021, Limited value of pulse wave analysis in assessing arterial wave reflection and stiffness in the pulmonary artery, PHYSIOLOGICAL REPORTS, Vol: 9, ISSN: 2051-817X

Journal article

Khanolkar AR, Chaturvedi N, Kuan V, Davis D, Hughes A, Richards M, Bann D, Patalay Pet al., 2021, Socioeconomic inequalities in prevalence and development of multimorbidity across adulthood: A longitudinal analysis of the MRC 1946 National Survey of Health and Development in the UK, PLOS MEDICINE, Vol: 18, ISSN: 1549-1277

Journal article

Min JL, Hemani G, Hannon E, Dekkers KF, Castillo-Fernandez J, Luijk R, Carnero-Montoro E, Lawson DJ, Burrows K, Suderman M, Bretherick AD, Richardson TG, Klughammer J, Iotchkova V, Sharp G, Al Khleifat A, Shatunov A, Iacoangeli A, McArdle WL, Ho KM, Kumar A, Soderhall C, Soriano-Tarraga C, Giralt-Steinhauer E, Kazmi N, Mason D, McRae AF, Corcoran DL, Sugden K, Kasela S, Cardona A, Day FR, Cugliari G, Viberti C, Guarrera S, Lerro M, Gupta R, Bollepalli S, Mandaviya P, Zeng Y, Clarke T-K, Walker RM, Schmoll V, Czamara D, Ruiz-Arenas C, Rezwan F, Marioni RE, Lin T, Awaloff Y, Germain M, Aissi D, Zwamborn R, van Eijk K, Dekker A, van Dongen J, Hottenga J-J, Willemsen G, Xu C-J, Barturen G, Catala-Moll F, Kerick M, Wang C, Melton P, Elliott HR, Shin J, Bernard M, Yet I, Smarts M, Gorrie-Stone T, Shaw C, Al Chalabi A, Ring SM, Pershagen G, Melen E, Jimenez-Conde J, Roquer J, Lawlor DA, Wright J, Martin NG, Montgomery GW, Moffitt TE, Poulton R, Esko T, Milani L, Metspalu A, Perry JRB, Ong KK, Wareham NJ, Matullo G, Sacerdote C, Panico S, Caspi A, Arseneault L, Gagnon F, Ollikainen M, Kaprio J, Felix JF, Rivadeneira F, Tiemeier H, van IJzendoorn MH, Uitterlinden AG, Jaddoe VWV, Hale C, McIntosh AM, Evans KL, Murray A, Raikkonen K, Lahti J, Nohr EA, Sorensen TIA, Hansen T, Morgen CS, Binder EB, Lucae S, Gonzalez JR, Bustamante M, Sunyer J, Holloway JW, Karmaus W, Zhang H, Deary IJ, Wray NR, Starr JM, Beekman M, VanHeemst D, Slagboom PE, Morange P-E, Tregouet D-A, Veldink JH, Davies GE, de Geus EJC, Boomsma D, Vonk JM, Brunekreef B, Koppelman GH, Alarcon-Riquelme ME, Huang R-C, Pennell CE, van Meurs J, Ikram MA, Hughes AD, Tillin T, Chaturvedi N, Pausova Z, Paus T, Spector TD, Kumari M, Schalkwyk LC, Visscher PM, Smith GD, Bock C, Gaunt TR, Bell JT, Heijmans BT, Mill J, Relton CLet al., 2021, Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation, NATURE GENETICS, Vol: 53, Pages: 1311-+, ISSN: 1061-4036

Journal article

Jones S, Schultz M, Park C, Tillin T, Chaturvedi N, Hughes Aet al., 2021, The effect of anti-hypertensive treatment on exercise blood pressure and exercise capacity in older adults, Publisher: SPRINGERNATURE, Pages: 6-6, ISSN: 0950-9240

Conference paper

Park C, Jones S, Howe L, Ferreira D, Fraser A, Lawlor D, Deanfield J, Williams S, Taylor H, Rapala A, Chaturvedi N, Hughes Aet al., 2021, Central pulse pressure in adolescence is more strongly associated with future left ventricle mass than brachial pulse pressure, Publisher: SPRINGERNATURE, Pages: 4-4, ISSN: 0950-9240

Conference paper

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