Imperial College London

ProfessorAlunHughes

Faculty of MedicineNational Heart & Lung Institute

Visiting Professor
 
 
 
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Contact

 

a.hughes Website

 
 
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Assistant

 

Mrs Kim Cyrus +44 (0)20 7594 6047

 
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Location

 

59/61 North Wharf RoadSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

1256 results found

Elliott HR, Burrows K, Min JL, Tillin T, Mason D, Wright J, Santorelli G, Smith GD, Lawlor DA, Hughes AD, Chaturvedi N, Relton CLet al., 2022, Characterisation of ethnic differences in DNA methylation between UK-resident South Asians and Europeans, CLINICAL EPIGENETICS, Vol: 14, ISSN: 1868-7075

Journal article

Aizawa K, Hughes AD, Casanova F, Gates PE, Mawson DM, Gooding KM, Gilchrist M, Goncalves I, Nilsson J, Khan F, Colhoun HM, Palombo C, Parker KH, Shore ACet al., 2022, Reservoir Pressure Integral Is Independently Associated With the Reduction in Renal Function in Older Adults, HYPERTENSION, Vol: 79, Pages: 2364-2372, ISSN: 0194-911X

Journal article

Bui T, Picone DS, Schultz MG, Armstrong MK, Peng X, Black JA, Dwyer N, Roberts-Thomson P, Adams H, Hughes AD, Sharman JEet al., 2022, Comparison between cuff-based and invasive systolic blood pressure amplification, JOURNAL OF HYPERTENSION, Vol: 40, Pages: 2037-2044, ISSN: 0263-6352

Journal article

Green MJ, Maddock J, Di Gessa G, Wielgoszewska B, Parsons S, Griffith GJ, Croft J, Stevenson AJ, Huggins CF, Booth C, Wels J, Silverwood RJ, Patalay P, Hughes AD, Chaturvedi N, Howe LD, Fitzsimons E, Katikireddi SV, Ploubidis GBet al., 2022, The UK Coronavirus Job Retention Scheme and smoking, alcohol consumption and vaping during the COVID-19 pandemic: evidence from eight longitudinal population surveys, BMC MEDICINE, Vol: 20, ISSN: 1741-7015

Journal article

Christie IN, Windsor R, Mutsaerts HJMM, Tillin T, Sudre CH, Hughes AD, Golay X, Gourine A, Hosford PSet al., 2022, Cerebral perfusion in untreated, controlled, and uncontrolled hypertension, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, ISSN: 0271-678X

Journal article

Molinari M, Cremaschi A, De Iorio M, Chaturvedi N, Hughes A, Tillin Tet al., 2022, Bayesian dynamic network modelling: an application to metabolic associations in cardiovascular diseases, JOURNAL OF APPLIED STATISTICS, ISSN: 0266-4763

Journal article

Knuppel A, Eastwood SV, Silverwood RJ, Tilling KM, Hughes AD, Williams DM, Chaturvedi Net al., 2022, The role of glycated haemoglobin, body mass index and waist-to-hip ratio in determining the risk of COVID-19 and long COVID, Publisher: SPRINGER, Pages: S188-S189, ISSN: 0012-186X

Conference paper

Wels J, Booth C, Wielgoszewska B, Green MJ, Di Gessa G, Huggins CF, Griffith GJ, Kwong ASF, Bowyer RCE, Maddock J, Patalay P, Silverwood RJ, Fitzsimons E, Shaw R, Thompson EJ, Steptoe A, Hughes A, Chaturvedi N, Steves CJ, Katikireddi SV, Ploubidisb GBet al., 2022, Mental and social wellbeing and the UK coronavirus job retention scheme: Evidence from nine longitudinal studies, SOCIAL SCIENCE & MEDICINE, Vol: 308, ISSN: 0277-9536

Journal article

Jamieson A, Astin R, Bell R, Hamer M, Howes LH, Heightman M, Hillman T, Hughes A, Montgomery H, Al Saikhan L, Scully M, Treibel T, Jones Set al., 2022, Skeletal muscle oxygen consumption and oxidative capacity in long COVID measured using Near Infrared Spectroscopy (NIRS), Publisher: WILEY, Pages: 723-723, ISSN: 1748-1708

Conference paper

Jones S, Schultz MG, Park C, Tillin T, Chaturvedi N, Hughes ADet al., 2022, Antihypertensive treatment effect on exercise blood pressure and exercise capacity in older adults, JOURNAL OF HYPERTENSION, Vol: 40, Pages: 1682-1691, ISSN: 0263-6352

Journal article

Mason SA, Al Saikhan L, Jones S, James S-N, Murray-Smith H, Rapala A, Williams S, Sudre C, Wong B, Richards M, Fox NC, Hardy R, Schott JM, Chaturvedi N, Hughes ADet al., 2022, Association between carotid atherosclerosis and brain activation patterns during the Stroop task in older adults: An fNIRS investigation, NEUROIMAGE, Vol: 257, ISSN: 1053-8119

Journal article

Picone DS, Stoneman E, Cremer A, Schultz MG, Otahal P, Hughes AD, Black JA, Bos WJ, Chen C-H, Cheng H-M, Dwyer N, Lacy P, Laugesen E, Liang F, Kim H-L, Ohte N, Okada S, Omboni S, Ott C, Pereira T, Pucci G, Rajani R, Schmieder R, Sinha MD, Stewart R, Stouffer GA, Takazawa K, Wang J, Weber T, Westerhof BE, Williams B, Yamada H, Sharman JEet al., 2022, Sex Differences in Blood Pressure and Potential Implications for Cardiovascular Risk Management., Hypertension

BACKGROUND: Accurate blood pressure (BP) measurement is critical for optimal cardiovascular risk management. Age-related trajectories for cuff-measured BP accelerate faster in women compared with men, but whether cuff BP represents the intraarterial (invasive) aortic BP is unknown. This study aimed to determine the sex-differences between cuff BP, invasive aortic BP, and the difference between the 2 measurements. METHODS: Upper-arm cuff BP and invasive aortic BP were measured during coronary angiography in 1615 subjects from the Invasive Blood Pressure Consortium Database. This analysis comprised 22 different cuff BP devices from 28 studies. RESULTS: Subjects were 64±11 years (range 40-89) and 32% women. For the same cuff systolic BP (SBP), invasive aortic SBP was 4.4 mm Hg higher in women compared with men. Cuff and invasive aortic SBP were higher in women compared with men, but the sex-difference was more pronounced from invasive aortic SBP, was the lowest in younger ages, and the highest in older ages. Cuff diastolic blood pressure overestimated invasive diastolic blood pressure in both sexes. For cuff and invasive diastolic blood pressure separately, there were sex*age interactions in which diastolic blood pressure was higher in younger men and lower in older men, compared with women. Cuff pulse pressure underestimated invasive aortic pulse pressure in excess of 10 mm Hg for both sexes in older age. CONCLUSIONS: For the same cuff SBP, invasive aortic SBP was higher in women compared with men. How this translates to cardiovascular risk prediction needs to be determined, but women may be at higher BP-related risk than estimated by cuff measurements.

Journal article

Joshi R, Wannamethee G, Engmann J, Gaunt T, Lawlor D, Price J, Tillin T, Chaturvedi N, Kivimaki M, Hughes A, Wong A, Hingorani AD, Schmidt AFet al., 2022, ASSOCIATION OF TRIGLYCERIDE AND CHOLESTEROL CONTENT IN FOURTEEN LIPOPROTEIN SUBFRACTIONS WITH CORONARY HEART DISEASE: A MENDELIAN RANDOMISATION ANALYSIS, Publisher: ELSEVIER IRELAND LTD, Pages: E148-E149, ISSN: 0021-9150

Conference paper

Wielgoszewska B, Maddock J, Green MJ, Di Gessa G, Parsons S, Griffith GJ, Croft J, Stevenson AJ, Booth C, Silverwood RJ, Bann D, Patalay P, Hughes AD, Chaturvedi N, Howe LD, Fitzsimons E, Katikireddi SV, Ploubidis GBet al., 2022, The UK Coronavirus Job Retention Scheme and diet, physical activity, and sleep during the COVID-19 pandemic: evidence from eight longitudinal population surveys (vol 20, 147, 2022), BMC MEDICINE, Vol: 20, ISSN: 1741-7015

Journal article

Sudre CH, Moriconi S, Rehwald R, Smith L, Tillin T, Barnes J, Atkinson D, Ourselin S, Chaturvedi N, Hughes AD, Jaeger HR, Cardoso MJet al., 2022, Accelerated vascular aging: Ethnic differences in basilar artery length and diameter, and its association with cardiovascular risk factors and cerebral small vessel disease, FRONTIERS IN CARDIOVASCULAR MEDICINE, Vol: 9, ISSN: 2297-055X

Journal article

Jones S, Tillin T, Williams S, Rapala A, Chaturvedi N, Hughes ADet al., 2022, Skeletal Muscle Tissue Saturation Changes Measured Using Near Infrared Spectroscopy During Exercise Are Associated With Post-Occlusive Reactive Hyperaemia, FRONTIERS IN PHYSIOLOGY, Vol: 13

Journal article

Alfarih M, Augusto JB, Knott KD, Fatih N, Kumar-M P, Boubertakh R, Hughes A, Moon J, Weingartner S, Captur Get al., 2022, Saturation-pulse prepared heart-rate independent inversion-recovery (SAPPHIRE) biventricular T1 mapping: inter-field strength, head-to-head comparison of diastolic, systolic and dark-blood measurements, BMC MEDICAL IMAGING, Vol: 22, ISSN: 1471-2342

Journal article

To C, Aizawa K, Gates PE, Parker KH, Hughes AD, Shore ACet al., 2022, SHORT-TERM HIGH SALT INTAKE ADVERSELY AFFECTS PARAMETERS DERIVED FROM RESERVOIR-EXCESS PRESSURE ANALYSIS AND CENTRAL ARTERY HAEMODYNAMICS IN OVERWEIGHT/OBESE ADULTS, Journal of hypertension, Vol: 40

OBJECTIVE: The association between high salt intake and blood pressure is well-recognised. In overweight/obese individuals, obesity-associated hyperinsulinaemia augments renal sodium reabsorption and in combination with high salt intake this may alter blood pressure and arterial haemodynamics. We determined whether short-term high salt intake altered reservoir-excess pressure and central artery haemodynamic parameters in overweight/obese individuals. DESIGN AND METHOD: We studied 15 middle-aged and older adults (59.3 ± 6.4 yrs, 5F) who were overweight/obese with elevated systolic blood pressure (130 < SBP < 159 mmHg). In a double-blind cross-over design, they were randomly assigned to seven days of low salt diet (LSD: 50 mmol/day) or high salt intake (HIS: LSD with 200 mmol/day of sodium tablets) separated by a two-week washout period. The parameters derived from reservoir-excess pressure analysis including reservoir pressure integral, peak reservoir pressure (MAXPR), excess pressure integral (INTXSP), peak excess pressure (MAXXSP), systolic rate constant and diastolic rate constant (DRC) were obtained by radial artery tonometry. Additionally central artery haemodynamic parameters including aortic systolic pressure (aSBP), diastolic pressure (aDBP), pulse pressure (aPP) and subendocardial viability index (SVI) were derived from ensemble-averaged radial pulse waveform using generalised transfer function. Aortic pulse wave velocity (aPWV) was estimated as proposed by Hughes et al (Front Physiol. 2020). RESULTS: MAXPR (111.0 ± 10.9 vs 105.4 ± 10.4 mmHg), MAXXSP (41.7 ± 12.0 vs 36.6 ± 5.7 mmHg) and DRC (2.0 ± 0.4 vs 1.8 ± 0.3 s-1) were higher following HIS compared to LSD (p < 0.05). There was no convincing evidence that INTXSP was greater following HIS than LSD (6.9 ± 3.2 vs 5.8 ± 1.6 mmHg s, p = 0.055). aSBP (126.3 ± 15.4 vs 117.6 ± 10.1 mmHg), aDBP (76.3 ± 6.2 vs 73.1 ±

Journal article

Hughes R, Ojrzynska-Witek N, Augusto J, Bhuva A, Parry-Williams G, Papatheodorou S, D'Silva A, Torlasco C, Manisty C, Hughes A, Sharma S, Moon Jet al., 2022, MASTERS ATHLETES DEMONSTRATE SEX DIFFERENCES IN AORTIC STIFFNESS, Publisher: BMJ PUBLISHING GROUP, Pages: A111-A111, ISSN: 1355-6037

Conference paper

O'Nunain KM, Park CD, Urquijo H, Leyden GG, Hughes A, Davey Smith G, Richardson Tet al., 2022, A lifecourse mendelian randomization study highlights the long-term influence of childhood body size on later life heart structure, PLOS BIOLOGY, Vol: 20, ISSN: 1544-9173

Journal article

Jordan AN, Aizawa K, Gooding KM, Llewellyn D, Casanova F, Mawson DM, Gates PE, Adingupu DD, Elyas S, Hope SV, Strain WD, Clark CE, Bellenger NG, Sharp ASP, Parker KH, Hughes AD, Shore ACet al., 2022, ARTERIAL HAEMODYNAMIC PARAMETERS LINKED TO ARTERIAL PULSATILITY, EXCESS WAVE PROPAGATION AND COGNITIVE FUNCTION, Journal of hypertension, Vol: 40

OBJECTIVE: Hypertension is associated with the development of cognitive impairment and dementia in an ageing population. Aortic stiffness and alterations in central artery haemodynamics could intensify the penetration of excess wave energy into the cerebral circulation, damaging the microvasculature in addition to age-associated vascular changes. We aimed to determine whether haemodynamic parameters linked to arterial pulsatility and excess wave propagation was associated with cognitive function in a sample of normotensive and hypertensive individuals. DESIGN AND METHOD: We studied 35 treatment-naïve patients with stage II/III hypertension (HT: 63.8 ± 7.4yrs, 19F, SBP 175.6 ± 16.8 mmHg) and 35 age-, sex- and body mass index-matched normotensive individuals (NT: SBP 127.2 ± 8.2 mmHg). Indices of excess pressure including excess pressure integral (INTXSP) and peak excess pressure (MAXXSP) were obtained by radial artery tonometry. Aortic forward compression wave intensity (FCWI) and aortic pulse wave velocity (aPWV) were estimated as proposed by Hughes et al (Front Physiol. 2020). A battery of cognitive examination tests was administered including Addenbrooke's Cognitive Examination-III (ACE), Mini-Mental State Examination (MMSE), Trail making test part A (TMT-A) and B (TMT-B). RESULTS: Both INTXSP (9.2 ± 2.7 vs 5.4 ± 1.2 mmHg s) and MAXXSP (54.1 ± 12.8 vs 33.4 ± 5.9 mmHg) were significantly higher in HT compared to NT (p < 0.001). Additionally, FCWI [14.9 (12.0-20.0) vs 8.0 (6.8-9.3) x105 W/m2] and aPWV (7.2 ± 1.7 vs 4.5 ± 0.8 m/s) were significantly greater in HT compared with NT (p < 0.001). Higher INTXSP was associated with poorer ACE (rs = -0.310, p = 0.009), longer TMT-A (r = 0.409, p < 0.001) and TMT-B (r = 0.380, p = 0.001). Similarly, higher MAXXSP was associated with poorer ACE (rs = -0.343, p = 0.004), longer TMT-A (r = 0.397, p = 0.001) and TMT-B (r = 0.330, p = 0.006), and greater

Journal article

Molinari M, Cremaschi A, De Iorio M, Chaturvedi N, Hughes AD, Tillin Tet al., 2022, Bayesian nonparametric modelling of multiple graphs with an application to ethnic metabolic differences, JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES C-APPLIED STATISTICS, ISSN: 0035-9254

Journal article

Al Saikhan L, Park C, Tillin T, Lloyd G, Mayet J, Chaturvedi N, Hughes ADet al., 2022, Relationship Between Image Quality and Bias in 3D Echocardiographic Measures: Data From the SABRE (Southall and Brent Revisited) Study, JOURNAL OF THE AMERICAN HEART ASSOCIATION, Vol: 11

Journal article

Charalambous C, Moon JC, Holly JMP, Chaturvedi N, Hughes AD, Captur Get al., 2022, Declining Levels and Bioavailability of IGF-I in Cardiovascular Aging Associate With QT Prolongation-Results From the 1946 British Birth Cohort, FRONTIERS IN CARDIOVASCULAR MEDICINE, Vol: 9, ISSN: 2297-055X

Journal article

Elliott HR, Burrows K, Min JL, Tillin T, Mason D, Wright J, Santorelli G, Smith GD, Lawlor DA, Hughes AD, Chaturvedi N, Relton CLet al., 2022, Characterisation of ethnic differences in DNA methylation between UK resident South Asians and Europeans

<jats:title>Abstract</jats:title><jats:p>Ethnic differences in non-communicable disease risk have been described between individuals of South Asian and European ethnicity that are only partially explained by genetics and other known risk factors. DNA methylation is one underexplored mechanism that may explain differences in disease risk. Currently there is little knowledge of how DNA methylation varies between South Asian and European ethnicities.</jats:p><jats:p>This study characterised differences in blood DNA methylation between individuals of self-reported European and South Asian ethnicity from two UK-based cohorts; Southall and Brent Revisited (SABRE) and Born in Bradford (BiB). DNA methylation differences between ethnicities were widespread throughout the genome (n=16,433 CpG sites, 3.4% sites tested). Specifically, 76% of associations were attributable to ethnic differences in cell composition with fewer effects attributable to smoking and genetic variation. Ethnicity associated CpG sites were enriched for EWAS Catalog phenotypes including metabolites. This work highlights the need to consider ethnic diversity in epigenetic research.</jats:p>

Journal article

Wielgoszewska B, Maddock J, Green MJ, Di Gessa G, Parsons S, Griffith GJ, Croft J, Stevenson AJ, Booth C, Silverwood RJ, Bann D, Patalay P, Hughes AD, Chaturvedi N, Howe LD, Fitzsimons E, Katikireddi SV, Ploubidis GBet al., 2022, The UK Coronavirus Job Retention Scheme and diet, physical activity, and sleep during the COVID-19 pandemic: evidence from eight longitudinal population surveys, BMC MEDICINE, Vol: 20, ISSN: 1741-7015

Journal article

Anbar R, Sultan SR, Al Saikhan L, Alkharaiji M, Chaturvedi N, Hardy R, Richards M, Hughes Aet al., 2022, Is carotid artery atherosclerosis associated with poor cognitive function assessed using the Mini-Mental State Examination? A systematic review and meta-analysis, BMJ OPEN, Vol: 12, ISSN: 2044-6055

Journal article

Webber M, Falconer D, AlFarih M, Joy G, Chan F, Davie C, Hamill Howes L, Wong A, Rapala A, Bhuva A, Davies RH, Morton C, Aguado-Sierra J, Vazquez M, Tao X, Krausz G, Tanackovic S, Guger C, Xue H, Kellman P, Pierce I, Schott J, Hardy R, Chaturvedi N, Rudy Y, Moon JC, Lambiase PD, Orini M, Hughes AD, Captur Get al., 2022, Study protocol: MyoFit46-the cardiac sub-study of the MRC National Survey of Health and Development, BMC CARDIOVASCULAR DISORDERS, Vol: 22, ISSN: 1471-2261

Journal article

Fatih N, Chaturvedi N, Lane CA, Parker TD, Lu K, Cash DM, Malone IB, Silverwood R, Wong A, Barnes J, Sudre CH, Richards M, Fox NC, Schott JM, Hughes A, James S-Net al., 2022, Sex-related differences in whole brain volumes at age 70 in association with hyperglycemia during adult life, NEUROBIOLOGY OF AGING, Vol: 112, Pages: 161-169, ISSN: 0197-4580

Journal article

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