Publications
1335 results found
Seraphim A, Knott KD, Menacho K, et al., 2021, Prognostic Value of Pulmonary Transit Time and Pulmonary Blood Volume Estimation Using Myocardial Perfusion CMR, JACC-CARDIOVASCULAR IMAGING, Vol: 14, Pages: 2107-2119, ISSN: 1936-878X
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- Citations: 11
Webber M, Joy G, Falconer D, et al., 2021, MYOCARDIAL INFLAMMATION AND DIFFUSE FIBROSIS UNDERPIN THE ELECTROPHYSIOLOGICAL DERANGEMENTS OF THE AGEING HUMAN HEART-A CMR-ECGI STUDY, Annual Meeting of the British-Society-of-Cardiovascular-Magnetic-Resonance (BSCMR), Publisher: BMJ PUBLISHING GROUP, Pages: A10-A11, ISSN: 1355-6037
Fornasiero M, Pierce I, Webber M, et al., 2021, A MEDICAL DEVICE-GRADE T2 PHANTOM FOR QUALITY ASSURANCE OF INFLAMMATION IMAGING BY CMR, Annual Meeting of the British-Society-of-Cardiovascular-Magnetic-Resonance (BSCMR), Publisher: BMJ PUBLISHING GROUP, Pages: A9-A10, ISSN: 1355-6037
Gordillo-Maranon M, Zwierzyna M, Charoen P, et al., 2021, Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics, NATURE COMMUNICATIONS, Vol: 12
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- Citations: 3
Evans RA, McAuley H, Harrison EM, et al., 2021, Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study, The Lancet Respiratory Medicine, Vol: 9, Pages: 1275-1287, ISSN: 2213-2600
BACKGROUND: The impact of COVID-19 on physical and mental health and employment after hospitalisation with acute disease is not well understood. The aim of this study was to determine the effects of COVID-19-related hospitalisation on health and employment, to identify factors associated with recovery, and to describe recovery phenotypes. METHODS: The Post-hospitalisation COVID-19 study (PHOSP-COVID) is a multicentre, long-term follow-up study of adults (aged ≥18 years) discharged from hospital in the UK with a clinical diagnosis of COVID-19, involving an assessment between 2 and 7 months after discharge, including detailed recording of symptoms, and physiological and biochemical testing. Multivariable logistic regression was done for the primary outcome of patient-perceived recovery, with age, sex, ethnicity, body-mass index, comorbidities, and severity of acute illness as covariates. A post-hoc cluster analysis of outcomes for breathlessness, fatigue, mental health, cognitive impairment, and physical performance was done using the clustering large applications k-medoids approach. The study is registered on the ISRCTN Registry (ISRCTN10980107). FINDINGS: We report findings for 1077 patients discharged from hospital between March 5 and Nov 30, 2020, who underwent assessment at a median of 5·9 months (IQR 4·9-6·5) after discharge. Participants had a mean age of 58 years (SD 13); 384 (36%) were female, 710 (69%) were of white ethnicity, 288 (27%) had received mechanical ventilation, and 540 (50%) had at least two comorbidities. At follow-up, only 239 (29%) of 830 participants felt fully recovered, 158 (20%) of 806 had a new disability (assessed by the Washington Group Short Set on Functioning), and 124 (19%) of 641 experienced a health-related change in occupation. Factors associated with not recovering were female sex, middle age (40-59 years), two or more comorbidities, and more severe acute illness. The magnitude of the persistent health bur
Topriceanu C, Moon JC, Hardy R, et al., 2021, Childhood bradycardia associates with atrioventricular conduction defects in older age: a longitudinal birth cohort study, EUROPEAN HEART JOURNAL, Vol: 42, Pages: 2398-2398, ISSN: 0195-668X
Topriceanu C-C, Wong A, Moon JC, et al., 2021, Impact of lockdown on key workers: findings from the COVID-19 survey in four UK national longitudinal studies, JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, Vol: 75, Pages: 955-962, ISSN: 0143-005X
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- Citations: 9
Al Saikhan L, Park C, Tillin T, et al., 2021, Myocardial strain by 3D-speckle tracking echocardiography predicts long-term risk of cardiovascular morbidity and mortality in the general population: the Southall And Brent Revisited (SABRE) study, Publisher: OXFORD UNIV PRESS, Pages: 67-67, ISSN: 0195-668X
Ratneswaren A, Hadjiloizou N, Ahmad Y, et al., 2021, Coronary haemodynamics associated with left ventricular hypertrophy in aortic stenosis and hypertension, Publisher: OXFORD UNIV PRESS, Pages: 1728-1728, ISSN: 0195-668X
Ratneswaren A, Shah ASV, Thom SA, et al., 2021, Tissue Doppler E prime velocity and E/E prime predict 19-year cardiovascular mortality in hypertension, Publisher: OXFORD UNIV PRESS, Pages: 2336-2336, ISSN: 0195-668X
Gupta RK, Rosenheim J, Bell LC, et al., 2021, Blood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy study., The Lancet Microbe, Vol: 2, Pages: e508-e517, ISSN: 2666-5247
Background: We hypothesised that host-response biomarkers of viral infections might contribute to early identification of individuals infected with SARS-CoV-2, which is critical to breaking the chains of transmission. We aimed to evaluate the diagnostic accuracy of existing candidate whole-blood transcriptomic signatures for viral infection to predict positivity of nasopharyngeal SARS-CoV-2 PCR testing. Methods: We did a nested case-control diagnostic accuracy study among a prospective cohort of health-care workers (aged ≥18 years) at St Bartholomew's Hospital (London, UK) undergoing weekly blood and nasopharyngeal swab sampling for whole-blood RNA sequencing and SARS-CoV-2 PCR testing, when fit to attend work. We identified candidate blood transcriptomic signatures for viral infection through a systematic literature search. We searched MEDLINE for articles published between database inception and Oct 12, 2020, using comprehensive MeSH and keyword terms for "viral infection", "transcriptome", "biomarker", and "blood". We reconstructed signature scores in blood RNA sequencing data and evaluated their diagnostic accuracy for contemporaneous SARS-CoV-2 infection, compared with the gold standard of SARS-CoV-2 PCR testing, by quantifying the area under the receiver operating characteristic curve (AUROC), sensitivities, and specificities at a standardised Z score of at least 2 based on the distribution of signature scores in test-negative controls. We used pairwise DeLong tests compared with the most discriminating signature to identify the subset of best performing biomarkers. We evaluated associations between signature expression, viral load (using PCR cycle thresholds), and symptom status visually and using Spearman rank correlation. The primary outcome was the AUROC for discriminating between samples from participants who tested negative throughout the study (test-negative controls) and samples from participants with PCR-conf
O'Loughlin J, Casanova F, Hughes A, et al., 2021, HIGHER BMI CAUSES LOWER ODDS OF DEPRESSION IN INDIVIDUALS OF EAST ASIAN ANCESTRY, World Congress of Psychiatric Genetics (WCPG), Publisher: ELSEVIER, Pages: E210-E211, ISSN: 0924-977X
Schmidt AF, Hunt NB, Gordillo-Maranon M, et al., 2021, Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease, NATURE COMMUNICATIONS, Vol: 12
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- Citations: 27
Walton E, Marioni R, Elliott HR, et al., 2021, Characterizing the human methylome across the life course: findings from eight UK-based studies
<jats:title>Abstract</jats:title><jats:p>Variation in DNA methylation (DNAm) is associated with multiple biological processes that track growth and development, ageing and age-related diseases. However, there is little understanding of what constitutes typical patterns of DNAm variation and how these patterns change across the life course. In this study, we synthesised a map of the human methylome across the life course, focussing on changes in variability and mean DNAm.</jats:p><jats:p>Harmonizing DNAm datasets across eight longitudinal and cross-sectional UK-based studies, we meta-analysed n=13,215 blood samples from n=7,037 unique individuals from birth to 98 years of age. Changes in CpG-specific variability and means were described across the life course using a meta-regression framework. CpG-specific associations of variability or mean DNAm in relation to the likelihood of association with 100 traits linked to environmental exposures, health and disease were tested within and across ten developmental age bins across the life course.</jats:p><jats:p>Age was linked to DNAm variability at 29,212 CpG sites. On average, we observed a 1.26 fold increase in DNAm variability per year across the life course. 33,730 CpGs displayed changes in mean DNAm, with 64% of these loci showing decreases in DNAm over time. CpG sites linked to traits were in general more variable across the life course.</jats:p><jats:p>Our study provides, for the first time, a map of the human methylome across the life course, which is publicly accessible through a searchable online database. This resource allows researchers to query CpG-specific trajectories from birth to old age and link these to health and disease.</jats:p>
Min JL, Hemani G, Hannon E, et al., 2021, Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation, NATURE GENETICS, Vol: 53, Pages: 1311-+, ISSN: 1061-4036
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- Citations: 103
Khanolkar AR, Chaturvedi N, Kuan V, et al., 2021, Socioeconomic inequalities in prevalence and development of multimorbidity across adulthood: A longitudinal analysis of the MRC 1946 National Survey of Health and Development in the UK, PLOS MEDICINE, Vol: 18, ISSN: 1549-1277
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- Citations: 9
Armstrong MK, Schultz MG, Hughes AD, et al., 2021, Physiological and clinical insights from reservoir-excess pressure analysis, JOURNAL OF HUMAN HYPERTENSION, Vol: 35, Pages: 758-768, ISSN: 0950-9240
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- Citations: 4
Jones S, Schultz M, Park C, et al., 2021, The effect of anti-hypertensive treatment on exercise blood pressure and exercise capacity in older adults, Publisher: SPRINGERNATURE, Pages: 6-6, ISSN: 0950-9240
Park C, Jones S, Howe L, et al., 2021, Central pulse pressure in adolescence is more strongly associated with future left ventricle mass than brachial pulse pressure, Publisher: SPRINGERNATURE, Pages: 4-4, ISSN: 0950-9240
Clayton G, Howe L, Parks C, et al., 2021, The effect of pregnancy on cardiovascular health in early adulthood: a difference in difference analysis, INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, Vol: 50, ISSN: 0300-5771
Su J, Simonsen U, Mellemkjaer S, et al., 2021, Limited value of pulse wave analysis in assessing arterial wave reflection and stiffness in the pulmonary artery, PHYSIOLOGICAL REPORTS, Vol: 9, ISSN: 2051-817X
Feng L, Jehan I, de Silva HA, et al., 2021, Effect of a Multicomponent Intervention on Antihypertensive Medication Intensification in Rural South Asia: <i>Post Hoc</i> Analysis of a Cluster RCT, AMERICAN JOURNAL OF HYPERTENSION, Vol: 34, Pages: 981-988, ISSN: 0895-7061
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- Citations: 1
Huang Z, Park C, Chaturvedi N, et al., 2021, Cardiorespiratory fitness, fatness, and the acute blood pressure response to exercise in adolescence, SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, Vol: 31, Pages: 1693-1698, ISSN: 0905-7188
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- Citations: 4
Torlasco C, D'Silva A, Bhuva AN, et al., 2021, Age matters: differences in exercise-induced cardiovascular remodelling in young and middle aged healthy sedentary individuals., Eur J Prev Cardiol, Vol: 28, Pages: 738-746
AIMS: Remodelling of the cardiovascular system (including heart and vasculature) is a dynamic process influenced by multiple physiological and pathological factors. We sought to understand whether remodelling in response to a stimulus, exercise training, altered with healthy ageing. METHODS: A total of 237 untrained healthy male and female subjects volunteering for their first time marathon were recruited. At baseline and after 6 months of unsupervised training, race completers underwent tests including 1.5T cardiac magnetic resonance, brachial and non-invasive central blood pressure assessment. For analysis, runners were divided by age into under or over 35 years (U35, O35). RESULTS: Injury and completion rates were similar among the groups; 138 runners (U35: n = 71, women 49%; O35: n = 67, women 51%) completed the race. On average, U35 were faster by 37 minutes (12%). Training induced a small increase in left ventricular mass in both groups (3 g/m2, P < 0.001), but U35 also increased ventricular cavity sizes (left ventricular end-diastolic volume (EDV)i +3%; left ventricular end-systolic volume (ESV)i +8%; right ventricular end-diastolic volume (EDV)i +4%; right ventricular end-systolic volume (ESV)i +5%; P < 0.01 for all). Systemic aortic compliance fell in the whole sample by 7% (P = 0.020) and, especially in O35, also systemic vascular resistance (-4% in the whole sample, P = 0.04) and blood pressure (systolic/diastolic, whole sample: brachial -4/-3 mmHg, central -4/-2 mmHg, all P < 0.001; O35: brachial -6/-3 mmHg, central -6/-4 mmHg, all P < 0.001). CONCLUSION: Medium-term, unsupervised physical training in healthy sedentary individuals induces measurable remodelling of both heart and vasculature. This amount is age dependent, with predominant cardiac remodelling when younger and predominantly vascular remodelling when older.
Torlasco C, D'Silva A, Bhuva AN, et al., 2021, Age matters: differences in exercise-induced cardiovascular remodelling in young and middle aged healthy sedentary individuals, EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, Vol: 28, Pages: 738-746, ISSN: 2047-4873
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- Citations: 9
Aizawa K, Casanova F, Gates PE, et al., 2021, Reservoir-Excess Pressure Parameters Independently Predict Cardiovascular Events in Individuals With Type 2 Diabetes, HYPERTENSION, Vol: 78, Pages: 40-50, ISSN: 0194-911X
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- Citations: 2
Goudswaard LJ, Harrison S, Van de Klee D, et al., 2021, Blood pressure variability and night-time dipping assessed by 24-hour ambulatory monitoring: Cross-sectional association with cardiac structure in adolescents, PLOS ONE, Vol: 16, ISSN: 1932-6203
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- Citations: 2
Wielgoszewska B, Maddock J, Green MJ, et al., 2021, The UK Coronavirus Job Retention Scheme and changes in diet, physical activity and sleep during the COVID-19 pandemic: Evidence from eight longitudinal studies
<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>In March 2020 the UK implemented the Coronavirus Job Retention Scheme (furlough) to minimize job losses. Our aim was to investigate associations between furlough and diet, physical activity, and sleep during the early stages of the COVID-19 pandemic.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We analysed data from 25,092 participants aged 16 to 66 years from eight UK longitudinal studies. Changes in employment (including being furloughed) were defined by comparing employment status pre- and during the first lockdown. Health behaviours included fruit and vegetable consumption, physical activity, and sleeping patterns. Study-specific estimates obtained using modified Poisson regression, adjusting for socio-demographic characteristics and pre-pandemic health and health behaviours, were statistically pooled using random effects meta-analysis. Associations were also stratified by sex, age, and education.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Across studies, between 8 and 25% of participants were furloughed. Compared to those who remained working, furloughed workers were slightly less likely to be physically inactive (RR:0.85, [0.75-0.97], I<jats:sup>2=</jats:sup>59%) and did not differ in diet and sleep behaviours, although findings for sleep were heterogenous (I<jats:sup>2=</jats:sup>85%). In stratified analyses, furlough was associated with low fruit and vegetable consumption among males (RR=1.11; 95%CI: 1.01-1.22; I<jats:sup>2</jats:sup>: 0%) but not females (RR=0.84; 95%CI: 0.68-1.04; I<jats:sup>2</jats:sup>: 65%). Considering change in these health behaviours, furloughed workers were more likely than those who remained working to report increased fruit and vegetable consum
Huang Y, Gu B, Salles II, et al., 2021, Fibrinogen-mimicking, multi-arm nanovesicles for human thrombus-specific delivery of tissue plasminogen activator and targeted thrombolytic therapy, Science Advances, Vol: 7, ISSN: 2375-2548
Clinical use of tissue plasminogen activator (tPA) in thrombolytic therapy is limited by its short circulation time and hemorrhagic side effects. Inspired by fibrinogen binding to activated platelets, we report a fibrinogen-mimicking, multi-arm nanovesicle for thrombus-specific tPA delivery and targeted thrombolysis. This novel system is based on the lipid nanovesicle coated with polyethylene glycol (PEG) terminally conjugated with a cyclic RGD (cRGD) peptide. Our experiments with human blood demonstrated its highly selective binding to activated platelets and efficient tPA release at a thrombus site under both static and physiological flow conditions. Its clot dissolution time in a microfluidic system was comparable to that of free tPA. Furthermore, we report a purpose-built computational model capable of simulating targeted thrombolysis of the tPA-loaded nanovesicle and with potential in predicting the dynamics of thrombolysis in physiologically realistic scenarios. This combined experimental and computational work presents a promising platform for development of thrombolytic nanomedicines.
Comella A, Michail M, Chan J, et al., 2021, Patients with aortic stenosis exhibit early improved endothelial function following transcatheter aortic valve replacement: The eFAST study, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 332, Pages: 143-147, ISSN: 0167-5273
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- Citations: 5
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