Imperial College London
Alternate

ProfessorAlunHughes

Faculty of Medicine, National Heart & Lung Institute

Visiting Professor
 
 
 
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Contact

 

a.hughes Website

 
 
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Assistant

 

Mrs Kim Cyrus +44 (0)20 7594 6047

 
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Location

 

59/61 North Wharf RoadSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Huang:2021:10.1126/sciadv.abf9033,
author = {Huang, Y and Gu, B and Salles, II and Taylor, KA and Yu, L and Ren, J and Liu, X and Emerson, M and Longstaff, C and Hughes, AD and Thom, SA and Xu, XY and Chen, R},
doi = {10.1126/sciadv.abf9033},
journal = {Science Advances},
title = {Fibrinogen-mimicking, multi-arm nanovesicles for human thrombus-specific delivery of tissue plasminogen activator and targeted thrombolytic therapy},
url = {http://dx.doi.org/10.1126/sciadv.abf9033},
volume = {7},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Clinical use of tissue plasminogen activator (tPA) in thrombolytic therapy is limited by its short circulation time and hemorrhagic side effects. Inspired by fibrinogen binding to activated platelets, we report a fibrinogen-mimicking, multi-arm nanovesicle for thrombus-specific tPA delivery and targeted thrombolysis. This novel system is based on the lipid nanovesicle coated with polyethylene glycol (PEG) terminally conjugated with a cyclic RGD (cRGD) peptide. Our experiments with human blood demonstrated its highly selective binding to activated platelets and efficient tPA release at a thrombus site under both static and physiological flow conditions. Its clot dissolution time in a microfluidic system was comparable to that of free tPA. Furthermore, we report a purpose-built computational model capable of simulating targeted thrombolysis of the tPA-loaded nanovesicle and with potential in predicting the dynamics of thrombolysis in physiologically realistic scenarios. This combined experimental and computational work presents a promising platform for development of thrombolytic nanomedicines.
AU  - Huang,Y
AU  - Gu,B
AU  - Salles,II
AU  - Taylor,KA
AU  - Yu,L
AU  - Ren,J
AU  - Liu,X
AU  - Emerson,M
AU  - Longstaff,C
AU  - Hughes,AD
AU  - Thom,SA
AU  - Xu,XY
AU  - Chen,R
DO  - 10.1126/sciadv.abf9033
PY  - 2021///
SN  - 2375-2548
TI  - Fibrinogen-mimicking, multi-arm nanovesicles for human thrombus-specific delivery of tissue plasminogen activator and targeted thrombolytic therapy
T2  - Science Advances
UR  - http://dx.doi.org/10.1126/sciadv.abf9033
UR  - http://hdl.handle.net/10044/1/89297
VL  - 7
ER  -
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