Imperial College London
Alternate

ProfessorAlunHughes

Faculty of Medicine, National Heart & Lung Institute

Visiting Professor
 
 
 
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Contact

 

a.hughes Website

 
 
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Assistant

 

Mrs Kim Cyrus +44 (0)20 7594 6047

 
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Location

 

59/61 North Wharf RoadSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Elliott:2022:10.1101/2022.04.06.22273496,
author = {Elliott, HR and Burrows, K and Min, JL and Tillin, T and Mason, D and Wright, J and Santorelli, G and Smith, GD and Lawlor, DA and Hughes, AD and Chaturvedi, N and Relton, CL},
doi = {10.1101/2022.04.06.22273496},
title = {Characterisation of ethnic differences in DNA methylation between UK resident South Asians and Europeans},
url = {http://dx.doi.org/10.1101/2022.04.06.22273496},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>Ethnic differences in non-communicable disease risk have been described between individuals of South Asian and European ethnicity that are only partially explained by genetics and other known risk factors. DNA methylation is one underexplored mechanism that may explain differences in disease risk. Currently there is little knowledge of how DNA methylation varies between South Asian and European ethnicities.</jats:p><jats:p>This study characterised differences in blood DNA methylation between individuals of self-reported European and South Asian ethnicity from two UK-based cohorts; Southall and Brent Revisited (SABRE) and Born in Bradford (BiB). DNA methylation differences between ethnicities were widespread throughout the genome (n=16,433 CpG sites, 3.4% sites tested). Specifically, 76% of associations were attributable to ethnic differences in cell composition with fewer effects attributable to smoking and genetic variation. Ethnicity associated CpG sites were enriched for EWAS Catalog phenotypes including metabolites. This work highlights the need to consider ethnic diversity in epigenetic research.</jats:p>
AU  - Elliott,HR
AU  - Burrows,K
AU  - Min,JL
AU  - Tillin,T
AU  - Mason,D
AU  - Wright,J
AU  - Santorelli,G
AU  - Smith,GD
AU  - Lawlor,DA
AU  - Hughes,AD
AU  - Chaturvedi,N
AU  - Relton,CL
DO  - 10.1101/2022.04.06.22273496
PY  - 2022///
TI  - Characterisation of ethnic differences in DNA methylation between UK resident South Asians and Europeans
UR  - http://dx.doi.org/10.1101/2022.04.06.22273496
ER  -
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