Publications
78 results found
Avenoso D, Bradshaw A, Innes AJ, et al., 2016, Microbial Contamination of Haematopoietic Stem Cell Products: A Single Centre Experience, 59th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, Publisher: American Society of Hematology, Pages: 5741-5741, ISSN: 0006-4971
Pello O, Bradshaw A, Innes AJ, et al., 2016, Clinical Efficacy of BK Virus Specific T-Cells in Treatment of Severe Refractory Hemorrhagic Cystitis after HLA Haploidentical Transplantation, 59th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, Publisher: American Society of Hematology, Pages: 5726-5726, ISSN: 0006-4971
Beckerson J, Szydlo RM, Hickson M, et al., 2016, Impact of Nutrition on Non-Relapse Mortality and Acute Graft Versus Host Disease during Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies, 59th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, Publisher: American Society of Hematology, Pages: 2226-2226, ISSN: 0006-4971
Rohman PJ, Szydlo RM, Hobbs E, et al., 2016, Preconditioning Neutropenia Is a Key Prognostic Factor in Allogeneic Hematopoietic Cell Transplantation for High Risk Acute Myeloid Leukemia, 59th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, Publisher: American Society of Hematology, Pages: 3411-3411, ISSN: 0006-4971
Innes A, Apperley J, Allwood Z, et al., 2016, Development of acute graft-versus-host disease post allogeneic stem cell transplantation results in significant episodes of recurrent and prolonged hospitalisations which are with associated a significant economic burden to stem cell transplant units, 42nd Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation, Publisher: Nature Publishing Group, Pages: S575-S576, ISSN: 1476-5365
Innes AJ, Milojkovic D, Apperley JF, 2016, Allogeneic transplantation for CML in the TKI era: striking the right balance, NATURE REVIEWS CLINICAL ONCOLOGY, Vol: 13, Pages: 79-91, ISSN: 1759-4774
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- Citations: 27
Herranz N, Gallage S, Mellone M, et al., 2015, Erratum: mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype., Nat Cell Biol, Vol: 17
Herranz N, Gallage S, Mellone M, et al., 2015, mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype, Nature Cell Biology, Vol: 17, Pages: 1205-1217, ISSN: 1476-4679
Senescent cells secrete a combination of factors collectively known as the senescence-associated secretory phenotype (SASP). The SASP reinforces senescence and activates an immune surveillance response, but it can also show pro-tumorigenic properties and contribute to age-related pathologies. In a drug screen to find new SASP regulators, we uncovered the mTOR inhibitor rapamycin as a potent SASP suppressor. Here we report a mechanism by which mTOR controls the SASP by differentially regulating the translation of the MK2 (also known as MAPKAPK2) kinase through 4EBP1. In turn, MAPKAPK2 phosphorylates the RNA-binding protein ZFP36L1 during senescence, inhibiting its ability to degrade the transcripts of numerous SASP components. Consequently, mTOR inhibition or constitutive activation of ZFP36L1 impairs the non-cell-autonomous effects of senescent cells in both tumour-suppressive and tumour-promoting contexts. Altogether, our results place regulation of the SASP as a key mechanism by which mTOR could influence cancer, age-related diseases and immune responses.
Innes AJ, Apperley JF, 2014, Chronic Myeloid Leukemia-Transplantation in the Tyrosine Kinase Era, HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, Vol: 28, Pages: 1037-+, ISSN: 0889-8588
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- Citations: 10
Innes AJ, Beattie R, Sergeant R, et al., 2013, Escalating-dose HLA-mismatched DLI is safe for the treatment of leukaemia relapse following alemtuzumab-based myeloablative allo-SCT, BONE MARROW TRANSPLANTATION, Vol: 48, Pages: 1324-1328, ISSN: 0268-3369
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- Citations: 9
Innes AJ, Lurkins J, Szydlo R, et al., 2013, Long-term leukaemia control following DLI is independent of disease eradication, 39th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S251-S251, ISSN: 0268-3369
Beattie R, Sergeant R, Innes A, et al., 2013, The impact of HLA-DPB1 matching in unrelated donor haematopoietic stem cell transplantation: a single centre study, 39th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S100-S100, ISSN: 0268-3369
Innes AJ, Uttenthal B, Marley S, et al., 2013, Mesenchymal stromal cells protect from complement activation in graft-versus-host disease, 39th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S86-S86, ISSN: 0268-3369
Innes AJ, Beattie R, Sergeant R, et al., 2013, HLA-mismatched donor lymphocyte infusion is safe for the treatment of leukaemia relapse following alemtuzumab-based myeloablative allogeneic stem cell transplantation, 39th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S86-S87, ISSN: 0268-3369
Innes A, May PC, Pavlu J, et al., 2012, Unexpected pancytopenia following treatment of acute lymphoblastic leukemia, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 87, Pages: 412-412, ISSN: 0361-8609
Innes AJ, Lurkins J, Szydlo RM, et al., 2011, The Majority of Patients Receiving Donor Lymphocyte Infusions for Relapsed Chronic Myeloid Leukemia Remain PCR Positive Despite Maintaining Long-Term Remission, 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, Publisher: AMER SOC HEMATOLOGY, Pages: 1752-1752, ISSN: 0006-4971
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- Citations: 2
Bain BJ, Innes A, 2010, Unexpected immune hemolytic anemia in an intensive care ward patient, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 85, Pages: 181-181, ISSN: 0361-8609
Innes AJ, Kennedy G, McLaren M, et al., 2003, Dark chocolate inhibits platelet aggregation in healthy volunteers., Platelets, Vol: 14, Pages: 325-327
Cardiovascular disease is a leading cause of death in the UK. The flavonoids found in cocoa may produce a cardio-protective role for chocolate with a high cocoa content. Thirty healthy volunteers were randomised to receive 100 g of white, milk or dark chocolate, and assessments of platelet function were undertaken on venous blood samples before and after chocolate consumption. White and milk chocolate had no significant effect on platelets. However dark chocolate inhibited collagen-induced platelet aggregation in platelet rich plasma. In the future dark chocolate may have a role in prevention of cardiovascular and thromboembolic diseases.
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