Imperial College London
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DrAndrewInnes

Faculty of Medicine, Department of Immunology and Inflammation

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 4017a.innes

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{González-Meljem:2018:10.1007/978-3-319-95387-8_3,
author = {González-Meljem, JM and Hasting, S and Gallage, S and Innes, A},
booktitle = {Aging Research - Methodological Issues},
doi = {10.1007/978-3-319-95387-8_3},
editor = {García-Peña and Gutiérrez-Robledo and Pérez-Zepeda},
pages = {25--54},
publisher = {Springer},
title = {Biomedical research in aging.},
url = {http://dx.doi.org/10.1007/978-3-319-95387-8_3},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - CHAP
AB  - Biomedical research has been instrumental in identifying key molecular and cellular changes that occur throughout the aging process, also known as the Hallmarks of Aging. Notably, these are shared between humans and several other species that have served as models for the study of aging in the laboratory. In this chapter, we discuss current knowledge regarding the significance of hallmarks such as: decay of stem cell function, acquisition of genomic instability, DNA damage, telomere attrition, deregulated nutrient sensing, chronic inflammation and cellular senescence. We further describe current methodological issues, experimental techniques and best practices for the study of each hallmark across different in vivo and in vitro systems, while also pointing at their limitations. Finally, we provide future perspectives for the improvement of experimental designs in biomedical research of aging.
AU  - González-Meljem,JM
AU  - Hasting,S
AU  - Gallage,S
AU  - Innes,A
DO  - 10.1007/978-3-319-95387-8_3
EP  - 54
PB  - Springer
PY  - 2018///
SN  - 9783319953861
SP  - 25
TI  - Biomedical research in aging.
T1  - Aging Research - Methodological Issues
UR  - http://dx.doi.org/10.1007/978-3-319-95387-8_3
UR  - https://link.springer.com/chapter/10.1007%2F978-3-319-95387-8_3
ER  -
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