Imperial College London
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DrAndrewInnes

Faculty of Medicine, Department of Immunology and Inflammation

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 4017a.innes

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Innes:2021:10.1101/gad.343269.120,
author = {Innes, A and Sun, B and Wagner, V and Brookes, S and McHugh, D and Pombo, J and Porreca, RM and Dharmalingam, G and Vernia, S and Zuber, J and Vannier, J-B and García-Escudero, R and Gil, J},
doi = {10.1101/gad.343269.120},
journal = {Genes and Development},
pages = {379--391},
title = {XPO7 is a tumor suppressor regulating p21CIP1-dependent senescence},
url = {http://dx.doi.org/10.1101/gad.343269.120},
volume = {35},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Senescence is a key barrier to neoplastic transformation. To identify senescence regulators relevant to cancer, we screened a genome-wide shRNA library. Here, we describe exportin 7 (XPO7) as a novel regulator of senescence and validate its function in telomere-induced, replicative and oncogene-induced senescence (OIS). XPO7 is a bidirectional transporter that regulates the nuclear-cytoplasmic shuttling of a broad range of substrates. Depletion of XPO7 results in reduced levels of TCF3 and an impaired induction of the cyclin dependent kinase inhibitor p21CIP1 during OIS. Deletion of XPO7 correlates with poorer overall survival in several cancer types. Moreover, depletion of XPO7 alleviated OIS and increased tumor formation in a mouse model of liver cancer. Our results suggest that XPO7 is a novel tumor suppressor that regulates p21CIP1 expression to control senescence and tumorigenesis.
AU  - Innes,A
AU  - Sun,B
AU  - Wagner,V
AU  - Brookes,S
AU  - McHugh,D
AU  - Pombo,J
AU  - Porreca,RM
AU  - Dharmalingam,G
AU  - Vernia,S
AU  - Zuber,J
AU  - Vannier,J-B
AU  - García-Escudero,R
AU  - Gil,J
DO  - 10.1101/gad.343269.120
EP  - 391
PY  - 2021///
SN  - 0890-9369
SP  - 379
TI  - XPO7 is a tumor suppressor regulating p21CIP1-dependent senescence
T2  - Genes and Development
UR  - http://dx.doi.org/10.1101/gad.343269.120
UR  - http://genesdev.cshlp.org/content/35/5-6/379
UR  - http://hdl.handle.net/10044/1/85437
VL  - 35
ER  -
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