Publications
121 results found
Gupta AK, 2010, Racial differences in response to antihypertensive therapy: does one size fits all?, Int J Prev Med, Vol: 1, Pages: 217-219
Prieto-Merino D, Gupta AK, Dobson J, et al., 2009, ASCORE: an up-to-date cardiovascular risk score for hypertensive patients reflecting contemporary clinical practices developed using the ASCOT trial database, JOURNAL OF HUMAN HYPERTENSION, Vol: 23, Pages: 695-695, ISSN: 0950-9240
Prieto-Merino D, Gupta AK, Dobson J, et al., 2009, ASCORE: AN UP-TO-DATE CARDIOVASCULAR RISK SCORE FOR HYPERTENSIVE PATIENTS REFLECTING CONTEMPORARY CLINICAL PRACTICES DEVELOPED USING THE ASCOT TRIAL DATABASE, 19th European Meeting on Hypertension, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S315-S315, ISSN: 0263-6352
Gupta AK, Poulter NR, 2009, Blood pressure control in type 2 diabetes: an update of recent evidence, Hot Topics in Diabetes, Pages: 25-36, ISBN: 978-1-897859-97-1
Gupta AK, Venkataraman J, Collins OM, 2008, Measurement and Reduction of ISI in High-Dynamic-Range 1-bit Signal Generation, IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS I-REGULAR PAPERS, Vol: 55, Pages: 3593-3606, ISSN: 1549-8328
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- Citations: 14
Arshad S, Gupta AK, Poulter NR, 2008, Comparison of effectiveness and safety of fixed-dose combinations of antihypertensive agents with the free-drug combination of its components when given separately in hypertensive patients: a meta-analysis of 32 134 patients, JOURNAL OF HUMAN HYPERTENSION, Vol: 22, Pages: 726-726, ISSN: 0950-9240
Gupta AK, Poulter NR, Eldridge S, et al., 2008, Ethnic differences in blood pressure response to atenolol and amlodipine monotherapy and to add on diuretic and ACE inhibitor dual therapy in hypertensive patients from UK in ASCOT-BPLA, JOURNAL OF HUMAN HYPERTENSION, Vol: 22, Pages: 726-727, ISSN: 0950-9240
Gupta A, Dahlof B, Sever PS, et al., 2008, Relationship of baseline-and cumulative mean fasting plasma glucose with cardiovascular events and deaths among hypertensive patients in ASCOT-BPLA, EUROPEAN HEART JOURNAL, Vol: 29, Pages: 512-512, ISSN: 0195-668X
Poulter NR, Chang CL, Dahlof B, et al., 2008, Evaluating the efficacy of the stepped-care anti-hypertensive strategies used in the Anglo-Scandinavian Cardiac Outcomes Trial BP Lowering Arm (ASCOT-BPLA), 18th Scientific Meeting of the European-Society-of-Hypertension/22nd Scientific Meeting of the International-Society-of-Hypertension, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S10-S10, ISSN: 0263-6352
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- Citations: 1
Gupta AK, Dahlof B, Dobson J, et al., 2008, Determinants of new-onset diabetes among 19,257 hypertensive patients randomized in the anglo-scandinavian cardiac outcomes trial-blood pressure lowering arm and the relative influence of antihypertensive medication, Pages: 982-988, ISSN: 0149-5992
OBJECTIVE - The purpose of this study was to determine the baseline predictors of new- onset diabetes (NOD) in hypertensive patients and to develop a risk score to identify those at high risk of NOD. RESEARCH DESIGN AND METHODS - Among 19,257 hypertensive patients in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA) who were randomly assigned to receive one of two antihypertensive regimens (atenolol ± thiazide or amlodipine ± perindopril), 14,120 were at risk of developing diabetes at baseline. Of these, 1,366 (9.7%) subsequently developed NOD during median follow-up of 5.5 years. A multivariate Cox model was developed to identify the independent predictors of NOD and individual risk scores. RESULTS - NOD was significantly associated with an increase in baseline fasting plasma glucose (FPG), BMI, serum triglycerides, and systolic blood pressure. In contrast, amlodipine ± perindopril in comparison with atenolol ± thiazide treatment (hazard ratio 0.66 [95% CI 0.59-0.74]), high HDL cholesterol, alcohol use, and age >55 years were found to be significantly protective factors. FPG was the most powerful predictor with risk increasing by 5.8 times (95% CI 5.23-6.43) for each millimole per liter rise >5 mmol/l. The risk of NOD increased steadily with increasing quartile of risk score, with a 19-fold increase (95% CI 14.3-25.4) among those in the highest compared with those in the lowest quartile. The model showed excellent internal validity and discriminative ability. CONCLUSIONS - Baseline FPG >5 mmol/l, BMI, and use of an atenolol ± diuretic regimen were among the major determinants of NOD in hypertensive patients. The model developed from these data allows accurate prediction of NOD among hypertensive subjects. © 2008 by the American Diabetes Association.
Gupta AK, Dahlof B, Dobson J, et al., 2008, Determinants of new-onset diabetes among 19,257 hypertensive patients randomized in the Anglo-Scandinavian Cardiac Outcomes Trial-blood pressure lowering arm and the relative influence of antihypertensive medication, DIABETES CARE, Vol: 31, Pages: 982-988, ISSN: 0149-5992
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- Citations: 124
Gupta AK, Poulter NR, 2008, Diabetogenicity of antihypertensive therapy in’ Editors Jiten Vora, Hot Topics in Diabetes, London, UK, Publisher: Synergy medical communications, Pages: 23-32
Gupta AK, Poulter NR, Dahlof B, et al., 2007, Role of metabolic syndrome, independent of its components, in prediction of cardiovascular outcomes in hypertensive patients in the ASCOT-BPLA, JOURNAL OF HUMAN HYPERTENSION, Vol: 21, Pages: 836-837, ISSN: 0950-9240
Gupta AK, Poulter NR, 2007, Antihypertensive-associated incident diabetes: Controversy persists, ARCHIVES OF INTERNAL MEDICINE, Vol: 167, Pages: 1433-1433, ISSN: 0003-9926
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- Citations: 1
Gupta AK, Poulter N, 2007, Improving the prognosis in patients with diabetes: What will ADVANCE tell us?, AMERICAN JOURNAL OF HYPERTENSION, Vol: 20, Pages: 19S-22S, ISSN: 0895-7061
Gupta AK, Poulter NR, Dahlot B, et al., 2007, Role of metabolic syndrome, independent of its components, in prediction of cardiovascular outcomes in hypertensive patients of ASCOT- BPLA, 56th Annual Scientific Session of the American-College-of-Cardiology, Publisher: ELSEVIER SCIENCE INC, Pages: 417A-417A, ISSN: 0735-1097
Gupta AK, Poulter NR, Dahlof B, et al., 2006, Determinants of new onset diabetes among hypertensive patients randomised in the ASCOT-BPLA trial, 21sth Scientific Meeting of the International-Society-of-Hypertension/5th Asian-Pacific Congress of Hypertension/29th Annual Scientific Meeting of the Japanese-Society-of-Hypertension, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: 43-43, ISSN: 0263-6352
Gupta AK, Ahuja J, Fraser K, 2006, Primary Prevention of Diabetes Mellitus: Present and Future, Contemporary Perspectives on Clinical Pharmacotherapeutics, Editors: Kohli, New Delhi, India, Publisher: Elsevier, Pages: 519-533
Ahuja J, Gupta AK, Gupta M, et al., 2004, Thalidomide Rediscovered, Journal of Indian Academy of Clinical Medicine, Vol: 5, Pages: 34-38
Ahuja J, Gupta M, Gupta AK, et al., 2004, Pharmacoeconomics, Vol: 17, Pages: 80-83
Makkar RPS, Arora A, Monga A, et al., 2003, Burning feet syndrome. A clinical review., Aust Fam Physician, Vol: 32, Pages: 1006-1009, ISSN: 0300-8495
BACKGROUND: Burning pain in the feet has been known to occur as a distinct clinical symptom for almost two centuries. Despite being a common and fascinating clinical entity, this syndrome has received scant attention in the medical literature and has been described only in anecdotal reports. OBJECTIVE: This article describes and discusses the various aspects of this intriguing syndrome. DISCUSSION: Burning feet syndrome (BFS) is a common disorder especially among the elderly and is frequently encountered in general practice. There is no specific aetiology and it can occur as an isolated symptom or as part of a symptom complex in a variety of clinical settings. In contrast to the presence of distressing subjective symptoms, the physical examination is marked by a paucity of objective signs. The pathophysiology of BFS is not very clear and treatment varies depending on the aetiology.
Monga A, Makkar RP, Arora A, et al., 2003, Case report: Acute hepatitis E infection with coexistent glucose-6-phosphate dehydrogenase deficiency., Can J Infect Dis, Vol: 14, Pages: 230-231, ISSN: 1180-2332
Hepatitis E virus is one of the leading causes of acute viral hepatitis in India but usually manifests as a mild self-limiting illness. Viral hepatitis in the presence of glucose-6-phosphate dehydrogenase (G6PD) deficiency may be associated with complications such as severe anemia, hemolysis, renal failure, hepatic encephalopathy and even death. The incidence of G6PD deficiency in the general population of northern India is reported to be between 2.2% and 14%. Despite both hepatitis E infection and G6PD deficiency being common, their impact on patient illness has only recently been reported. The present study reports a case of severe hemolysis in a patient with G6PD deficiency and hepatitis E infection.
Makkar RPS, Arora A, Monga A, et al., 2003, Alport's syndrome with blue sclera., J Assoc Physicians India, Vol: 51, Pages: 510-511, ISSN: 0004-5772
An Indian case of Alport's syndrome who had association of keratoglobus and blue sclerae is described.
Singh NP, Arora SK, Gupta A, et al., 2003, Stroke: A rare presentation of cardiac hydatidosis, NEUROLOGY INDIA, Vol: 51, Pages: 120-121, ISSN: 0028-3886
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- Citations: 8
Makkar RPS, Mukhopadhyay S, Monga A, et al., 2003, Palmar erythema and hoarseness: an unusual clinical presentation of sarcoidosis, MEDICAL JOURNAL OF AUSTRALIA, Vol: 178, Pages: 75-76, ISSN: 0025-729X
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- Citations: 4
Monga A, Arora A, Makkar RPS, et al., 2003, Hypertriglyceridemia-induced acute pancreatitis--treatment with heparin and insulin., Indian J Gastroenterol, Vol: 22, Pages: 102-103, ISSN: 0254-8860
Heparin and insulin stimulate lipoprotein lipase and are known to decrease serum triglyceride levels. However, their efficacy in hypertriglyceridemia-induced acute pancreatitis is not well documented. We report a 51-year-old man in whom treatment with heparin and insulin was accompanied by reduction in serum triglyceride levels and resolution of pancreatitis.
Makkar RPS, Monga A, Arora A, et al., 2003, Self-referral to specialists--a dodgy proposition., Int J Health Care Qual Assur Inc Leadersh Health Serv, Vol: 16, Pages: 87-89, ISSN: 1366-0756
Patients are often ill-equipped to know which speciality to choose for their health problem. Especially in the presence of non-specific symptoms, choosing the right specialist might not be so obvious. In such cases, misdirected self-referrals by patients to self-chosen specialists can sometimes lead to misdiagnosis resulting in unwarranted delays in getting the right treatment. The general physicians, on the other hand, are in a unique position to oversee the big picture of patients' health, and are therefore better equipped to identify and sort out their individual health problems. Hence instead of a specialist if the first place of contact for patients is a general physician, they are likely to be guided along the right path of treatment for their various health problems. Such a system will minimize errors on the part of the patients by making certain that they are referred to the appropriate specialists.
Monga A, Arora A, Makkar RPS, et al., 2002, A rare site for tuberculosis, CANADIAN MEDICAL ASSOCIATION JOURNAL, Vol: 167, Pages: 1149-1150, ISSN: 0820-3946
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- Citations: 7
Makkar RPS, Mukhopadhyay S, Monga A, et al., 2002, Plasmodium vivax malaria presenting with severe thrombocytopenia., Braz J Infect Dis, Vol: 6, Pages: 263-265, ISSN: 1413-8670
Plasmodium falciparum and Plasmodium vivax malaria are endemic infections in India and are commonly associated with mild hematological abnormalities. Severe thrombocytopenia is common in isolated falciparum and mixed falciparum/vivax malaria, but is very rare in isolated P.vivax infection. We hereby report a case of severe thrombocytopenia (platelet count of 8x10(9)/L) in a case of vivax malaria. This is only the second case ever reported in the literature of such profound thrombocytopenia in a case of isolated P.vivax malaria.
Anuradha S, Agarwal SK, Singh NP, et al., 2002, An unusual presentation of the Papillon-Lefevre syndrome as recurrent liver abscesses., J Assoc Physicians India, Vol: 50, Pages: 974-976, ISSN: 0004-5772
The Papillon-Lefevre syndrome is a rare genetic disorder with a predisposition to severe infections. We describe Papillon-Lefevre syndrome in a 17 year old boy from a family where four out of eight siblings were affected with this disease and who presented with recurrent pyogenic liver abscesses over a period of 9 years, an association never previously reported.
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