Publications
81 results found
Murakarni Y, Almeida A, Layton M, et al., 2007, A point mutation in an Sp1 binding motif in the promoter of the mannosyltransferase-encoding <i>PIG-M</i> gene causes inherited glycosylphosphatidylinositol deficiency, 21st International Complement Workshop, Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 218-218, ISSN: 0161-5890
Almeida AM, Murakami Y, Baker A, et al., 2006, Targeted molecular therapy for inherited glycosylphosphatidylinositol deficiency., 48th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 148A-148A, ISSN: 0006-4971
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- Citations: 1
Karadimitris A, Patterson S, Spanoudakis E, 2006, Natural killer T cells and haemopoiesis, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 134, Pages: 263-272, ISSN: 0007-1048
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- Citations: 4
Almeida AM, Murakami Y, Layton DM, et al., 2006, Hypomorphic promoter mutation in <i>PIGM</i> causes inherited glycosylphosphatidylinositol deficiency, NATURE MEDICINE, Vol: 12, Pages: 846-851, ISSN: 1078-8956
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- Citations: 163
Kotsianidis L, Silk JD, Spanoudakis E, et al., 2006, Regulation of hematopoiesis in vitro and in vivo by invariant NKT cells, BLOOD, Vol: 107, Pages: 3138-3144, ISSN: 0006-4971
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- Citations: 26
Almeida A, Murakami Y, Hillmen P, et al., 2006, Characterisation of the biochemical and genetic defect in congenital glycosylphosphatidylinositol (GPI) deficiency, 46th Annual Scientific Meetign of the British-Society-for-Haematology, Publisher: BLACKWELL PUBLISHING, Pages: 23-23, ISSN: 0007-1048
Politou M, Karadimitris A, Terpos E, et al., 2006, No evidence of mutations of the <i>PSMB5</i> (beta-5 subunit of proteasome) in a case of myeloma with clinical resistance to bortezomib, LEUKEMIA RESEARCH, Vol: 30, Pages: 240-241, ISSN: 0145-2126
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- Citations: 50
Kotsianidis I, Silk JD, Patterson S, et al., 2005, Regulation of hematopoiesis in vitro and in vivo by invariant NKT cells., 47th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 641A-642A, ISSN: 0006-4971
Almeida AM, Hillmen P, Richards SJ, et al., 2005, Defective modification of mannose residues by terminal phosphoethanolamine underlies inherited GPI deficiency., 47th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 41A-41A, ISSN: 0006-4971
Patterson S, Kotsianidis L, Almeida A, et al., 2005, Human invariant NKT cells are required for effective in vitro alloresponses, JOURNAL OF IMMUNOLOGY, Vol: 175, Pages: 5087-5094, ISSN: 0022-1767
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- Citations: 8
Patterson S, Kotsiandis I, Almeida A, et al., 2004, Human CD4 negative NKT cells potently suppress alloreactive responses in a TGF-β and IL-10-Independent manner, 46th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 131A-131A, ISSN: 0006-4971
Pattersons S, Kotsianidis I, Almeida A, et al., 2004, Depletion of the CD1d-restricted NKT cells suppresses in vitro alloreactivity: A possible means to prevent aGVHD., 46th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 838A-839A, ISSN: 0006-4971
Kotsianidis L, Patterson S, Politou M, et al., 2004, Evidence that human NKT cells enhance haemopoiesis through recognition of CD1d expressed in haemopoietic stem cells with long term clonogenic capacity, 46th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 119B-119B, ISSN: 0006-4971
Karadimitris A, Araten DJ, Luzzatto L, et al., 2003, Severe telomere shortening in patients with paroxysmal nocturnal hemoglobinuria affects both GPI<SUP>-</SUP> and GPI<SUP>+</SUP> hematopoiesis, BLOOD, Vol: 102, Pages: 514-516, ISSN: 0006-4971
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- Citations: 18
Gadola SD, Karadimitris A, Zaccai NR, et al., 2003, Generation of CD1 tetramers as a tool to monitor glycolipid-specific T cells., Philos Trans R Soc Lond B Biol Sci, Vol: 358, Pages: 875-877, ISSN: 0962-8436
CD1 molecules are beta(2)m-associated HLA class-I-like glycoproteins which have the unique ability to present glycolipid and phospholipid antigens to specific T lymphocytes. To study the biology of CD1 and its role in human disease we developed novel techniques for generation of recombinant CD1/lipid complexes by in vitro refolding. Fluorescent tetrameric complexes made from soluble recombinant CD1d/alpha-galactosylceramide complexes allowed highly sensitive and specific ex vivo and in vitro detection and functional characterization of novel human T-lymphocyte populations. Furthermore, protein crystals were obtained from soluble recombinant CD1b/beta(2)m-proteins loaded either with phosphatidylinositol or ganglioside GM2, which led to the first atomic structure determination of a CD1/lipid complex. The analysis of these crystal structures clarified how CD1b molecules can bind lipid ligands of different size, and revealed a broader spectrum of potential CD1b ligands than previously predicted.
Marktel S, Marin D, Foot N, et al., 2003, Chronic myeloid leukemia in chronic phase responding to imatinib: the occurrence of additional cytogenetic abnormalities predicts disease progression, HAEMATOLOGICA, Vol: 88, Pages: 260-267, ISSN: 0390-6078
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- Citations: 76
Lucas M, Gadola S, Meier U, et al., 2003, Frequency and phenotype of circulating Valpha24/Vbeta11 double-positive natural killer T cells during hepatitis C virus infection., J Virol, Vol: 77, Pages: 2251-2257, ISSN: 0022-538X
Natural killer T (NKT) cells are thought to be involved in innate responses against infection. We investigated one specific type of NKT cell, Valpha24/Vbeta11 double positive, in hepatitis C virus (HCV) infection. Lower frequencies of this population were detected in the blood of HCV PCR-positive patients than in controls. Unlike Valpha24/Vbeta11 NKT cells found in blood, those in the liver appeared to be recently activated.
Terpos E, Hatziharissi E, Szydlo R, et al., 2002, Autologous stem cell transplantation improves abnormal bone turnover in multiple myeloma., 44th Annual Meeting of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, Pages: 434A-434A, ISSN: 0006-4971
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- Citations: 3
Karadimitris A, Li K, Notaro R, et al., 2001, Association of clonal T-cell large granular lymphocyte disease and paroxysmal nocturnal haemoglobinuria (PNH): further evidence for a pathogenetic link between T cells, aplastic anaemia and PNH, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 115, Pages: 1010-1014, ISSN: 0007-1048
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- Citations: 38
Karadimitris A, Gadola S, Altamirano M, et al., 2001, Human CD1d-glycolipid tetramers generated by <i>in vitro</i> oxidative refolding chromatography, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 98, Pages: 3294-3298, ISSN: 0027-8424
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- Citations: 169
Karadimitris A, Notaro R, Koehne G, et al., 2000, PNH cells are as sensitive to T-cell-mediated lysis as their normal counterparts: implications for the pathogenesis of paroxysmal nocturnal haemoglobinuria, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 111, Pages: 1158-1163, ISSN: 0007-1048
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- Citations: 29
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