Imperial College London
Portrait Picture

PROFESSOR AJIT LALVANI

Faculty of Medicine, National Heart & Lung Institute

Chair in Infectious Diseases
 
 
 
//

Contact

 

+44 (0)20 7594 0883a.lalvani

 
 
//

Assistant

 

Dr Luis Berrocal Almanza +44 (0)20 7594 3721

 
//

Location

 

Medical SchoolSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Hingley-Wilson:2014:10.1016/j.tube.2014.01.004,
author = {Hingley-Wilson, SM and Connell, D and Pollock, K and Hsu, T and Tchilian, E and Sykes, A and Grass, L and Potiphar, L and Bremang, S and Kon, OM and Jacobs, WR and Lalvani, A},
doi = {10.1016/j.tube.2014.01.004},
journal = {TUBERCULOSIS},
pages = {262--270},
title = {ESX1-dependent fractalkine mediates chemotaxis and Mycobacterium tuberculosis infection in humans},
url = {http://dx.doi.org/10.1016/j.tube.2014.01.004},
volume = {94},
year = {2014}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Mycobacterium tuberculosis-induced cellular aggregation is essential for granuloma formation and may assist establishment and early spread of M. tuberculosis infection. The M. tuberculosis ESX1 mutant, which has a non-functional type VII secretion system, induced significantly less production of the host macrophage-derived chemokine fractalkine (CX3CL1). Upon infection of human macrophages ESX1-dependent fractalkine production mediated selective recruitment of CD11b+ monocytic cells and increased infection of neighbouring cells consistent with early local spread of infection. Fractalkine levels were raised in vivo at tuberculous disease sites in humans and were significantly associated with increased CD11b+ monocytic cellular recruitment and extent of granulomatous disease. These findings suggest a novel fractalkine-dependent ESX1-mediated mechanism in early tuberculous disease pathogenesis in humans. Modulation of M. tuberculosis-mediated fractalkine induction may represent a potential treatment option in the future, perhaps allowing us to switch off a key mechanism required by the pathogen to spread between cells.
AU  - Hingley-Wilson,SM
AU  - Connell,D
AU  - Pollock,K
AU  - Hsu,T
AU  - Tchilian,E
AU  - Sykes,A
AU  - Grass,L
AU  - Potiphar,L
AU  - Bremang,S
AU  - Kon,OM
AU  - Jacobs,WR
AU  - Lalvani,A
DO  - 10.1016/j.tube.2014.01.004
EP  - 270
PY  - 2014///
SN  - 1472-9792
SP  - 262
TI  - ESX1-dependent fractalkine mediates chemotaxis and Mycobacterium tuberculosis infection in humans
T2  - TUBERCULOSIS
UR  - http://dx.doi.org/10.1016/j.tube.2014.01.004
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000335913700009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/62137
VL  - 94
ER  -
Download