Imperial College London

ProfessorAllanLawrie

Faculty of MedicineNational Heart & Lung Institute

Chair of Pulmonary Vascular Diseases
 
 
 
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Contact

 

+44 (0)20 7594 6819a.lawrie Website

 
 
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Location

 

530ICTEM buildingHammersmith Campus

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Summary

 

Summary

Allan completed his PhD “The effects of ultrasound on vascular gene delivery” (Supervisor - Prof Chris Newman) in the Department of Cardiovascular Science at the University of Sheffield in 2002. Allan followed this with a post-doctoral position with Prof Marlene Rabinovitch at Stanford University, California where he developed an interest in the molecular mechanisms of Pulmonary Hypertension.

Allan returned to the University of Sheffield in 2004 to establish a translational science research programme in Pulmonary Hypertension. Allan has been successful in obtaining early career and senior Fellowships from the Medical Research Council and British Heart Foundation focused on understanding the role of the osteoprotegerin (OPG) / tumor necrosis factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) axis in PH. Allan also obtained a Medical Research Council DPFS award to co-develop a novel therapeutic antibody targeting OPG for the treatment of pulmonary hypertension. Working closely colleagues in Sheffield all co-launched and Directed the formation of the Donald Heath Centre for Pulmonary Hypertension research. 

Allan moved to the National Heart and Lung Institute at Imperial College London in April 2022.

Research Interests

Allan maintains a strong interest in understanding the molecular mechanisms underlying pulmonary hypertension with a firm focus on translation in areas of novel therapies, biomarkers.

Allan has also developed an interest in the use of ‘Real-World’ data including healthcare resource utilisation and personal monitoring (activity) data to improve early disease detection and monitoring. Working across academia and industry partners Allan's research has utilised artificial intelligence and machine learning models to develop algorithms that can be applied to NHS Coding data (Hospital Episode Statistics), 'Omic data, and most recently personal activity data to identify clusters and trajectories of patients.

Allan current research is focused around the heterogeneity that exists across socioeconomic groups, physical activity, clinical phenotype, and biology with the aim of developing digital biomarkers for cardiovascular disease that can help predict and monitor disease, and hospitalisation.

Internal Professional Activities


Allan sits on the Executive Committee for the Imperial British Heart Foundation Centre of Excellence (https://www.imperial.ac.uk/bhf-research-excellence/), is a Co-Director of the British Heart Foundation 4-year Doctoral Training Programme, and Chair of the NHLI Research Committee, Research Lead and Open Research Champion for NHLI and representative for the Faculty of Medicine Research Committee.

External Professional Activities

In addition to serving on grant panels and an active manuscript reviewer all is a Fellow of the Pulmonary Vascular Research Institute, sits on the Research committee, and is a Trustee of the Board of Scleroderma & Raynaud's UK.


Publications

Journals

Alhathli E, Julian T, Girach ZUA, et al., 2024, Mendelian randomization study with clinical follow-up links metabolites to risk and severity of pulmonary arterial hypertension, Journal of the American Heart Association, Vol:13, ISSN:2047-9980

Yogeswaran A, Gall H, Fünderich M, et al., 2024, Comparison of contemporary risk scores in all groups of pulmonary hypertension - a PVRI GoDeep meta-registry analysis, Chest, ISSN:0012-3692

Lord JM, Veenith T, Sullivan J, et al., 2024, Accelarated immune ageing is associated with COVID-19 disease severity, Immunity and Ageing, Vol:21, ISSN:1742-4933

Ulrich A, Wu Y, Draisma H, et al., 2024, Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension, Nature Communications, Vol:15, ISSN:2041-1723

Kiely DG, Hamilton N, Wood S, et al., 2024, Risk assessment and real-world outcomes in chronic thromboembolic pulmonary hypertension: insights from a UK pulmonary hypertension referral service, Bmj Open, Vol:14, ISSN:2044-6055

More Publications