Imperial College London
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ProfessorArmandLeroi

Faculty of Natural Sciences, Department of Life Sciences

Professor of Evolutionary Developmental Biology
 
 
 
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Contact

 

+44 (0)20 7594 2396a.leroi Website

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lozano:2006:10.1016/j.cub.2006.01.048,
author = {Lozano, E and Sáez, AG and Flemming, AJ and Cunha, A and Leroi, AM},
doi = {10.1016/j.cub.2006.01.048},
journal = {Current Biology},
pages = {493--498},
title = {Regulation of growth by ploidy in Caenorhabditis elegans.},
url = {http://dx.doi.org/10.1016/j.cub.2006.01.048},
volume = {16},
year = {2006}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Some animals, such as the larvae of Drosophila melanogaster, the larvae of the Appendicularian chordate Oikopleura, and the adults of the nematode Caenorhabditis elegans, are unusual in that they grow largely by increases in cell size. The giant cells of such species are highly polyploid, having undergone repeated rounds of endoreduplication. Since germline polyploid strains tend to have large cells, it is often assumed that endoreduplication drives cell growth, but this remains controversial. We have previously shown that adult growth in C. elegans is associated with the endoreduplication of nuclei in the epidermal syncitium, hyp 7. We show here that this relationship is causal. Manipulation of somatic ploidy both upwards and downwards increases and decreases, respectively, adult body size. We also establish a quantitative relationship between ploidy and body size. Finally, we find that TGF-beta (DBL-1) and cyclin E (CYE-1) regulate body size via endoreduplication. To our knowledge, this is the first experimental evidence establishing a cause-and-effect relationship between somatic polyploidization and body size in a metazoan.
AU  - Lozano,E
AU  - Sáez,AG
AU  - Flemming,AJ
AU  - Cunha,A
AU  - Leroi,AM
DO  - 10.1016/j.cub.2006.01.048
EP  - 498
PY  - 2006///
SN  - 0960-9822
SP  - 493
TI  - Regulation of growth by ploidy in Caenorhabditis elegans.
T2  - Current Biology
UR  - http://dx.doi.org/10.1016/j.cub.2006.01.048
UR  - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16527744&query_hl=1
VL  - 16
ER  -
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