Publications

BibTex format

@article{Davies:2015:10.1021/acs.jproteome.5b00442,
author = {Davies, SK and Bundy, JG and Leroi, AM},
doi = {10.1021/acs.jproteome.5b00442},
journal = {Journal of Proteome Research},
pages = {4603--4609},
title = {Metabolic Youth in Middle Age: Predicting Aging in Caenorhabditis elegans Using Metabolomics},
url = {http://dx.doi.org/10.1021/acs.jproteome.5b00442},
volume = {14},
year = {2015}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Many mutations and allelic variants are known that influence the rate at which animals age. But when in life do such variants diverge from normal patterns of ageing? And is this divergence visible in their physiologies? To investigate these questions we have used 1H NMR spectroscopy to study how the metabolome of the nematode Caenorhabditis elegans changes as it grows older. We identify a series of metabolic changes that, collectively, predict the age of wild-type worms. We then show that long-lived mutant daf-2(m41) worms are metabolically youthful compared to wild-type worms - but that this relative youth only appears in middle age. Finally, we show that metabolic age predicts the timing and magnitude of differences in age-specific mortality between these strains. Thus the future mortality of these two genotypes can be predicted long before most of the worms die.
AU  - Davies,SK
AU  - Bundy,JG
AU  - Leroi,AM
DO  - 10.1021/acs.jproteome.5b00442
EP  - 4609
PY  - 2015///
SN  - 1535-3907
SP  - 4603
TI  - Metabolic Youth in Middle Age: Predicting Aging in Caenorhabditis elegans Using Metabolomics
T2  - Journal of Proteome Research
UR  - http://dx.doi.org/10.1021/acs.jproteome.5b00442
UR  - http://hdl.handle.net/10044/1/27169
VL  - 14
ER  -

Download

ProfessorArmandLeroi

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)