Imperial College London
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ProfessorArmandLeroi

Faculty of Natural Sciences, Department of Life Sciences

Professor of Evolutionary Developmental Biology
 
 
 
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Contact

 

+44 (0)20 7594 2396a.leroi Website

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Davies:2016:10.1111/evo.13020,
author = {Davies, SK and Leroi, A and Burt, A and Bundy, JG and Baer, CF},
doi = {10.1111/evo.13020},
journal = {Evolution},
pages = {2239--2246},
title = {The mutational structure of metabolism in Caenorhabditis elegans.},
url = {http://dx.doi.org/10.1111/evo.13020},
volume = {70},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - A properly functioning organism must maintain metabolic homeostasis. Deleterious mutations degrade organismal function, presumably at least in part via effects on metabolic function. Here we present an initial investigation into the mutational structure of the Caenorhabditis elegans metabolome by means of a mutation accumulation experiment. We find that pool sizes of 29 metabolites vary greatly in their vulnerability to mutation, both in terms of the rate of accumulation of genetic variance (the mutational variance, VM) and the rate of change of the trait mean (the mutational bias, ΔM). Strikingly, some metabolites are much more vulnerable to mutation than any other trait previously studied in the same way. Although we cannot statistically assess the strength of mutational correlations between individual metabolites, principal component analysis provides strong evidence that some metabolite pools are genetically correlated, but also that there is substantial scope for independent evolution of different groups of metabolites. Averaged over MA lines, PC3 is positively correlated with relative fitness, but a model in which metabolites are uncorrelated with fitness is nearly as good by Akaike's Information Criterion (AIC). This article is protected by copyright. All rights reserved.
AU  - Davies,SK
AU  - Leroi,A
AU  - Burt,A
AU  - Bundy,JG
AU  - Baer,CF
DO  - 10.1111/evo.13020
EP  - 2246
PY  - 2016///
SN  - 0014-3820
SP  - 2239
TI  - The mutational structure of metabolism in Caenorhabditis elegans.
T2  - Evolution
UR  - http://dx.doi.org/10.1111/evo.13020
UR  - http://hdl.handle.net/10044/1/52862
VL  - 70
ER  -
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