Imperial College London
Alternate

Prof Andrew G. Livingston

Faculty of Engineering, Department of Chemical Engineering

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 5582a.livingston Website

 
 
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Assistant

 

Miss Jessica Baldock +44 (0)20 7594 5699

 
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Location

 

413ACE ExtensionSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dong:2019:10.1038/s41557-018-0169-6,
author = {Dong, R and Liu, R and Gaffney, P and Schaepertoens, M and Marchetti, P and Williams, C and Chen, R and Livingston, A},
doi = {10.1038/s41557-018-0169-6},
journal = {Nature Chemistry},
pages = {136--145},
title = {Sequence-defined multifunctional polyethers via liquid-phase synthesis with molecular sieving},
url = {http://dx.doi.org/10.1038/s41557-018-0169-6},
volume = {11},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Synthetic chemists have devoted tremendous effort towards the production of precision synthetic polymers with defined sequences and specific functions. However, the creation of a general technology that enables precise control over monomer sequence, with efficient isolation of the target polymers, is highly challenging. Here, we report a robust strategy for the production of sequence-defined synthetic polymers through a combination of liquid-phase synthesis and selective molecular sieving. The polymer is assembled in solution with real-time monitoring to ensure couplings proceed to completion, on a three-armed star-shaped macromolecule to maximize efficiency during the molecular sieving process. This approach is applied to the construction of sequence-defined polyethers, with side-arms at precisely defined locations that can undergo site-selective modification after polymerization. Using this versatile strategy, we have introduced structural and functional diversity into sequence-defined polyethers, unlocking their potential for real-life applications in nanotechnology, healthcare and information storage.
AU  - Dong,R
AU  - Liu,R
AU  - Gaffney,P
AU  - Schaepertoens,M
AU  - Marchetti,P
AU  - Williams,C
AU  - Chen,R
AU  - Livingston,A
DO  - 10.1038/s41557-018-0169-6
EP  - 145
PY  - 2019///
SN  - 1755-4330
SP  - 136
TI  - Sequence-defined multifunctional polyethers via liquid-phase synthesis with molecular sieving
T2  - Nature Chemistry
UR  - http://dx.doi.org/10.1038/s41557-018-0169-6
UR  - http://hdl.handle.net/10044/1/65448
VL  - 11
ER  -
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