Imperial College London

DrAlexanderLyon

Faculty of MedicineNational Heart & Lung Institute

Clinical Senior Lecturer in Heart Failure
 
 
 
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Contact

 

+44 (0)20 7594 3409a.lyon Website

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

176 results found

Hilfiker-Kleiner D, Ardehali H, Fischmeister R, Burridge P, Hirsch E, Lyon ARet al., 2019, Late onset heart failure after childhood chemotherapy, EUROPEAN HEART JOURNAL, Vol: 40, Pages: 798-800, ISSN: 0195-668X

JOURNAL ARTICLE

de Boer RA, De Keulenaer G, Bauersachs J, Brutsaert D, Cleland JG, Diez J, Du X-J, Ford P, Heinzel FR, Lipson KE, McDonagh T, Lopez-Andres N, Lunde IG, Lyon AR, Pollesello P, Prasad SK, Tocchetti CG, Mayr M, Sluijter JPG, Thum T, Tschoepe C, Zannad F, Zimmermann W-H, Ruschitzka F, Filippatos G, Lindsey ML, Maack C, Heymans Set al., 2019, Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 21, Pages: 272-285, ISSN: 1388-9842

JOURNAL ARTICLE

Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, White HD, Mickley H, Crea F, Van de Werf F, Bucciarelli-Ducci C, Katus HA, Pinto FJ, Antman EM, Hamm CW, De Caterina R, Januzzi JL, Apple FS, Alonso Garcia MA, Underwood SR, Canty JM, Lyon AR, Devereaux PJ, Luis Zamorano J, Lindahl B, Weintraub WS, Newby LK, Virmani R, Vranckx P, Cutlip D, Gibbons RJ, Smith SC, Atar D, Luepker RV, Robertson RM, Bonow RO, Steg PG, O'Gara PT, Fox KAA, Hasdai D, Aboyans V, Achenbach S, Agewall S, Alexander T, Avezum A, Barbato E, Bassand J-P, Bates E, Bittl JA, Breithardt G, Bueno H, Bugiardini R, Cohen MG, Dangas G, de Lemos JA, Delgado V, Filippatos G, Fry E, Granger CB, Halvorsen S, Hlatky MA, Ibanez B, James S, Kastrati A, Leclercq C, Mahaffey KW, Mehta L, Muller C, Patrono C, Piepoli MF, Pineiro D, Roffi M, Rubboli A, Sharma S, Simpson IA, Tendera M, Valgimigli M, van der Wal AC, Windecker Set al., 2019, Fourth universal definition of myocardial infarction (2018), EUROPEAN HEART JOURNAL, Vol: 40, Pages: 237-269, ISSN: 0195-668X

JOURNAL ARTICLE

Lyon AR, 2019, Heart failure resulting from cancer treatment: still serious but an opportunity for prevention, HEART, Vol: 105, Pages: 6-8, ISSN: 1355-6037

JOURNAL ARTICLE

Maack C, Lehrke M, Backs J, Heinzel FR, Hulot J-S, Marx N, Paulus WJ, Rossignol P, Taegtmeyer H, Bauersachs J, Bayes-Genis A, Brutsaert D, Bugger H, Clarke K, Cosentino F, De Keulenaer G, Dei Cas A, Gonzalez A, Huelsmann M, Iaccarino G, Lunde IG, Lyon AR, Pollesello P, Rena G, Riksen NP, Rosano G, Staels B, van Laake LW, Wanner C, Farmakis D, Filippatos G, Ruschitzka F, Seferovic P, de Boer RA, Heymans Set al., 2018, Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology, EUROPEAN HEART JOURNAL, Vol: 39, Pages: 4243-+, ISSN: 0195-668X

JOURNAL ARTICLE

Anker MS, Lena A, Hadzibegovic S, Belenkov Y, Bergler-Klein J, de Boer RA, Cohen-Solal A, Farmakis D, von Haehling S, Lopez-Fernandez T, Pudil R, Suter T, Tocchetti CG, Lyon ARet al., 2018, Modern-day cardio-oncology: a report from the 'Heart Failure and World Congress on Acute Heart Failure 2018', ESC HEART FAILURE, Vol: 5, Pages: 1083-1091, ISSN: 2055-5822

JOURNAL ARTICLE

Pareek N, Cevallos J, Moliner P, Shah M, Tan LL, Chambers V, Baksi AJ, Khattar RS, Sharma R, Rosen SD, Lyon ARet al., 2018, Activity and outcomes of a cardio-oncology service in the United Kingdom-a five-year experience, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 20, Pages: 1721-1731, ISSN: 1388-9842

JOURNAL ARTICLE

Rekha B, Velmurugan G, Freddy AJ, Anusha S, Ramprasath T, Karthik KV, Suresh S, Kulshrestha P, Mithieux G, Lyon AR, Selvam GS, Ramasamy Set al., 2018, Chronic intake of 4-Methylimidazole induces Hyperinsulinemia and Hypoglycaemia via Pancreatic Beta Cell Hyperplasia and Glucose Dyshomeostasis, Scientific Reports, Vol: 8

JOURNAL ARTICLE

Matthews A, Stanway S, Farmer RE, Strongman H, Thomas S, Lyon AR, Smeeth L, Bhaskaran Ket al., 2018, Long term adjuvant endocrine therapy and risk of cardiovascular disease in female breast cancer survivors: systematic review, BMJ-BRITISH MEDICAL JOURNAL, Vol: 363, ISSN: 1756-1833

JOURNAL ARTICLE

Maack C, Eschenhagen T, Hamdani N, Heinzel FR, Lyon AR, Manstein DJ, Metzger J, Papp Z, Tocchetti CG, Yilmaz MB, Anker SD, Balligand J-L, Bauersachs J, Brutsaert D, Carrier L, Chlopicki S, Cleland JG, de Boer RA, Dietl A, Fischmeister R, Harjola V-P, Heymans S, Hilfiker-Kleiner D, Holzmeister J, de Keulenaer G, Limongelli G, Linke WA, Lund LH, Masip J, Metra M, Mueller C, Pieske B, Ponikowski P, Ristic A, Ruschitzka F, Seferovic PM, Skouri H, Zimmermann WH, Mebazaa Aet al., 2018, Treatments targeting inotropy., Eur Heart J

Acute heart failure (HF) and in particular, cardiogenic shock are associated with high morbidity and mortality. A therapeutic dilemma is that the use of positive inotropic agents, such as catecholamines or phosphodiesterase-inhibitors, is associated with increased mortality. Newer drugs, such as levosimendan or omecamtiv mecarbil, target sarcomeres to improve systolic function putatively without elevating intracellular Ca2+. Although meta-analyses of smaller trials suggested that levosimendan is associated with a better outcome than dobutamine, larger comparative trials failed to confirm this observation. For omecamtiv mecarbil, Phase II clinical trials suggest a favourable haemodynamic profile in patients with acute and chronic HF, and a Phase III morbidity/mortality trial in patients with chronic HF has recently begun. Here, we review the pathophysiological basis of systolic dysfunction in patients with HF and the mechanisms through which different inotropic agents improve cardiac function. Since adenosine triphosphate and reactive oxygen species production in mitochondria are intimately linked to the processes of excitation-contraction coupling, we also discuss the impact of inotropic agents on mitochondrial bioenergetics and redox regulation. Therefore, this position paper should help identify novel targets for treatments that could not only safely improve systolic and diastolic function acutely, but potentially also myocardial structure and function over a longer-term.

JOURNAL ARTICLE

Lagarto JL, Dyer BT, Talbot CB, Peters NS, French PMW, Lyon AR, Dunsby Cet al., 2018, Characterization of NAD(P)H and FAD autofluorescence signatures in a Langendorff isolated-perfused rat heart model, BIOMEDICAL OPTICS EXPRESS, Vol: 9, Pages: 4961-4978, ISSN: 2156-7085

JOURNAL ARTICLE

Lyon AR, Yousaf N, Battisti NML, Moslehi J, Larkin Jet al., 2018, Immune checkpoint inhibitors and cardiovascular toxicity, LANCET ONCOLOGY, Vol: 19, Pages: E447-E458, ISSN: 1470-2045

JOURNAL ARTICLE

Meijers WC, Maglione M, Bakker SJL, Oberhuber R, Kieneker LM, de Jong S, Haubner BJ, Nagengast WB, Lyon AR, van der Vegt B, van Veldhuisen DJ, Westenbrink BD, van der Meer P, Sillje HHW, de Boer RAet al., 2018, Heart Failure Stimulates Tumor Growth by Circulating Factors, CIRCULATION, Vol: 138, Pages: 678-691, ISSN: 0009-7322

JOURNAL ARTICLE

Chari A, Stewart AK, Russell SD, Moreau P, Herrmann J, Banchs J, Hajek R, Groarke J, Lyon AR, Batty GN, Ro S, Huang M, Iskander KS, Lenihan Det al., 2018, Analysis of carfilzomib cardiovascular safety profile across relapsed and/or refractory multiple myeloma clinical trials, BLOOD ADVANCES, Vol: 2, Pages: 1633-1644, ISSN: 2473-9529

JOURNAL ARTICLE

Ghadri J-R, Wittstein IS, Prasad A, Sharkey S, Dote K, Akashi YJ, Cammann VL, Crea F, Galiuto L, Desmet W, Yoshida T, Manfredini R, Eitel I, Kosuge M, Nef HM, Deshmukh A, Lerman A, Bossone E, Citro R, Ueyama T, Corrado D, Kurisu S, Ruschitzka F, Winchester D, Lyon AR, Omerovic E, Bax JJ, Meimoun P, Tarantini G, Rihal C, Y-Hassan S, Migliore F, Horowitz JD, Shimokawa H, Luescher TF, Templin Cet al., 2018, International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology, EUROPEAN HEART JOURNAL, Vol: 39, Pages: 2032-2046, ISSN: 0195-668X

JOURNAL ARTICLE

Ghadri J-R, Wittstein IS, Prasad A, Sharkey S, Dote K, Akashi YJ, Cammann VL, Crea F, Galiuto L, Desmet W, Yoshida T, Manfredini R, Eitel I, Kosuge M, Nef HM, Deshmukh A, Lerman A, Bossone E, Citro R, Ueyama T, Corrado D, Kurisu S, Ruschitzka F, Winchester D, Lyon AR, Omerovic E, Bax JJ, Meimoun P, Tarantini G, Rihal C, -Hassan SY, Migliore F, Horowitz JD, Shimokawa H, Luscher TF, Templin Cet al., 2018, International Expert Consensus Document on Takotsubo Syndrome (Part II): Diagnostic Workup, Outcome, and Management, EUROPEAN HEART JOURNAL, Vol: 39, Pages: 2047-2062, ISSN: 0195-668X

JOURNAL ARTICLE

Ameri P, Canepa M, Anker MS, Belenkov Y, Bergler-Klein J, Cohen-Solal A, Farmakis D, Lopez-Fernandez T, Lainscak M, Pudil R, Ruschitska F, Seferovic P, Filippatos G, Coats A, Suter T, Von Haehling S, Ciardiello F, de Boer RA, Lyon AR, Tocchetti CGet al., 2018, Cancer diagnosis in patients with heart failure: epidemiology, clinical implications and gaps in knowledge, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 20, Pages: 879-887, ISSN: 1388-9842

JOURNAL ARTICLE

Patel HC, Hayward C, Wardle AJ, Middleton L, Lyon AR, Di Mario C, Salukhe TV, Sutton R, Rosen SDet al., 2018, The effect of head-up tilt upon markers of heart rate variability in patients with atrial fibrillation, ANNALS OF NONINVASIVE ELECTROCARDIOLOGY, Vol: 23, ISSN: 1082-720X

JOURNAL ARTICLE

Wright PT, Bhogal NK, Diakonov I, Pannell LMK, Perera RK, Bork NI, Schobesberger S, Lucarelli C, Faggian G, Alvarez-Laviada A, Zaccolo M, Kamp TJ, Balijepalli RC, Lyon AR, Harding SE, Nikolaev VO, Gorelik Jet al., 2018, Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in beta(2)AR-cAMP Responsiveness in Murine Hearts, CELL REPORTS, Vol: 23, Pages: 459-469, ISSN: 2211-1247

JOURNAL ARTICLE

Harper AR, Patel HC, Lyon AR, 2018, Heart failure with preserved ejection fraction, CLINICAL MEDICINE, Vol: 18, Pages: S24-S29, ISSN: 1470-2118

JOURNAL ARTICLE

Gorter TM, van Veldhuisen DJ, Bauersachs J, Borlaug BA, Celutkiene J, Coats AJS, Crespo-Leiro MG, Guazzi M, Harjola V-P, Heymans S, Hill L, Lainscak M, Lam CSP, Lund LH, Lyon AR, Mebazaa A, Mueller C, Paulus WJ, Pieske B, Piepoli MF, Ruschitzka F, Rutten FH, Seferovic PM, Solomon SD, Shah SJ, Triposkiadis F, Wachter R, Tschoepe C, de Boer RAet al., 2018, Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 20, Pages: 16-37, ISSN: 1388-9842

JOURNAL ARTICLE

Sikkel MB, Francis DP, Howard J, Gordon F, Rowlands C, Peters NS, Lyon AR, Harding SE, MacLeod KTet al., 2017, Hierarchical statistical techniques are necessary to draw reliable conclusions from analysis of isolated cardiomyocyte studies, CARDIOVASCULAR RESEARCH, Vol: 113, Pages: 1743-1752, ISSN: 0008-6363

JOURNAL ARTICLE

van Bilsen M, Patel HC, Bauersachs J, Boehm M, Borggrefe M, Brutsaert D, Coats AJS, de Boer RA, de Keulenaer G, Filippatos GS, Floras J, Grassi G, Jankowska EA, Kornet L, Lunde IG, Maack C, Mahfoud F, Pollesello P, Ponikowski P, Ruschitzka F, Sabbah HN, Schultz HD, Seferovic P, Slart RHJA, Taggart P, Tocchetti CG, Van Laake L, Zannad F, Heymans S, Lyon ARet al., 2017, The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 19, Pages: 1361-1378, ISSN: 1388-9842

JOURNAL ARTICLE

Bruengger AAS, Wechalekar K, Khattar R, Rosen SD, Robertus JL, Chau I, Morganstein D, Rosendahl U, Lyon A, Mohiaddin Ret al., 2017, Histologically Proven Myocardial Carcinoid Metastases: The Value of Multimodality Imaging, CANADIAN JOURNAL OF CARDIOLOGY, Vol: 33, ISSN: 0828-282X

JOURNAL ARTICLE

Kato K, Lyon AR, Ghadri J-R, Templin Cet al., 2017, Takotsubo syndrome: aetiology, presentation and treatment., Heart, Vol: 103, Pages: 1461-1469

JOURNAL ARTICLE

Lyon A, 2017, Stress in a Dish Exploring the Mechanisms of Takotsubo Syndrome, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 70, Pages: 992-995, ISSN: 0735-1097

JOURNAL ARTICLE

Mareev Y, Ramparsad N, McConnachie A, Olsson L, Lyon AR, Di Lenarda A, Komajda M, Torp-Pedersen C, Metra M, Swedberg K, Cleland JGet al., 2017, Carvedilol vs. metoprolol tartrate on mortality in patients with heart failure with a reduced ejection fraction and atrial fibrillation or sinus rhythm: a post-hoc analysis of COMET, Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 42-42, ISSN: 0195-668X

CONFERENCE PAPER

Cowie MR, Filippatos GS, Garcia MDLAA, Anker SD, Baczynska A, Bloomfield DM, Borentain M, Slot KB, Cronin M, Doevendans PA, El-Gazayerly A, Gimpelewicz C, Honarpour N, Janmohamed S, Janssen H, Kim AM, Lautsch D, Laws I, Lefkowitz M, Lopez-Sendon J, Lyon AR, Malik FI, McMurray JJV, Metra M, Perez SF, Pfeffer MA, Pocock SJ, Ponikowski P, Prasad K, Richard-Lordereau I, Roessig L, Rosano GMC, Sherman W, Stough WG, Swedberg K, Tyl B, Zannad F, Boulton C, De Graeff Pet al., 2017, New medicinal products for chronic heart failure: advances in clinical trial design and efficacy assessment, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 19, Pages: 718-727, ISSN: 1388-9842

JOURNAL ARTICLE

Schobesberger S, Wright P, Tokar S, Bhargava A, Mansfield C, Glukhov AV, Poulet C, Buzuk A, Monszpart A, Sikkel M, Harding SE, Nikolaev VO, Lyon AR, Gorelik Jet al., 2017, T-tubule remodelling disturbs localized beta(2)-adrenergic signalling in rat ventricular myocytes during the progression of heart failure, CARDIOVASCULAR RESEARCH, Vol: 113, Pages: 770-782, ISSN: 0008-6363

JOURNAL ARTICLE

Mareev Y, Lyon AR, Lane R, Rogers P, Butcher C, Smith R, Cleland Jet al., 2017, Why don't beta-blockers work in patients with heart failure and atrial fibrillation? Pauses?, Publisher: WILEY, Pages: 81-82, ISSN: 1388-9842

CONFERENCE PAPER

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