Imperial College London
Alternate

DrAlexanderLyon

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3409a.lyon Website

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lyon:2018:10.1016/S1470-2045(18)30457-1,
author = {Lyon, AR and Yousaf, N and Battisti, NML and Moslehi, J and Larkin, J},
doi = {10.1016/S1470-2045(18)30457-1},
journal = {LANCET ONCOLOGY},
pages = {E447--E458},
title = {Immune checkpoint inhibitors and cardiovascular toxicity},
url = {http://dx.doi.org/10.1016/S1470-2045(18)30457-1},
volume = {19},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Immune checkpoint inhibitors are a new class of anticancer therapies that amplify T-cell-mediated immune responses against cancer cells. Immune checkpoint inhibitors have shown important benefits in phase 3 trials, and several agents have been approved for specific malignancies. Although adverse events from immune checkpoint inhibitors are a common occurrence, cardiotoxic effects are uncommon, but are often serious complications with a relatively high mortality. Most cardiotoxic effects appear to be inflammatory in nature. Clinical assessment of a combination of biomarkers, electrocardiography, cardiac imaging, and endomyocardial biopsy can be used to confirm a possible diagnosis. In this Review, we discuss the epidemiology of immune checkpoint inhibitor-mediated cardiotoxic effects, as well as their clinical presentation, subtypes, risk factors, pathophysiology, and clinical management, including the introduction of a new surveillance strategy.
AU  - Lyon,AR
AU  - Yousaf,N
AU  - Battisti,NML
AU  - Moslehi,J
AU  - Larkin,J
DO  - 10.1016/S1470-2045(18)30457-1
EP  - 458
PY  - 2018///
SN  - 1470-2045
SP  - 447
TI  - Immune checkpoint inhibitors and cardiovascular toxicity
T2  - LANCET ONCOLOGY
UR  - http://dx.doi.org/10.1016/S1470-2045(18)30457-1
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000443278100016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/63354
VL  - 19
ER  -
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