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@article{Vallejo-Vaz:2021:10.1016/s0140-6736(21)01122-3,
author = {Vallejo-Vaz, AJ and Stevens, CAT and Lyons, ARM and Dharmayat, KI and Freiberger, T and Hovingh, GK and Mata, P and Raal, FJ and Santos, RD and Soran, H and Watts, GF and Abifadel, M and Aguilar-Salinas, CA and Alhabib, KF and Alkhnifsawi, M and Almahmeed, W and Alnouri, F and Alonso, R and Al-Rasadi, K and Al-Sarraf, A and Al-Sayed, N and Araujo, F and Ashavaid, TF and Banach, M and Béliard, S and Benn, M and Binder, CJ and Bogsrud, MP and Bourbon, M and Chlebus, K and Corral, P and Davletov, K and Descamps, OS and Durst, R and Ezhov, M and Gaita, D and Genest, J and Groselj, U and Harada-Shiba, M and Holven, KB and Kayikcioglu, M and Khovidhunkit, W and Lalic, K and Latkovskis, G and Laufs, U and Liberopoulos, E and Lima-Martinez, MM and Lin, J and Maher, V and Marais, AD and März, W and Mirrakhimov, E and Miserez, AR and Mitchenko, O and Nawawi, H and Nordestgaard, BG and Panayiotou, AG and Paragh, G and Petrulioniene, Z and Pojskic, B and Postadzhiyan, A and Raslova, K and Reda, A },
doi = {10.1016/s0140-6736(21)01122-3},
journal = {The Lancet},
pages = {1713--1725},
title = {Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)},
url = {http://dx.doi.org/10.1016/s0140-6736(21)01122-3},
volume = {398},
year = {2021}
}

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TY  - JOUR
AB  - BackgroundThe European Atherosclerosis Society Familial Hypercholesterolaemia Studies Collaboration (FHSC) global registry provides a platform for the global surveillance of familial hypercholesterolaemia through harmonisation and pooling of multinational data. In this study, we aimed to characterise the adult population with heterozygous familial hypercholesterolaemia and described how it is detected and managed globally.MethodsUsing FHSC global registry data, we did a cross-sectional assessment of adults (aged 18 years or older) with a clinical or genetic diagnosis of probable or definite heterozygous familial hypercholesterolaemia at the time they were entered into the registries. Data were assessed overall and by WHO regions, sex, and index versus non-index cases.FindingsOf the 61 612 individuals in the registry, 42 167 adults (21 999 [53·6%] women) from 56 countries were included in the study. Of these, 31 798 (75·4%) were diagnosed with the Dutch Lipid Clinic Network criteria, and 35 490 (84·2%) were from the WHO region of Europe. Median age of participants at entry in the registry was 46·2 years (IQR 34·3–58·0); median age at diagnosis of familial hypercholesterolaemia was 44·4 years (32·5–56·5), with 40·2% of participants younger than 40 years when diagnosed. Prevalence of cardiovascular risk factors increased progressively with age and varied by WHO region. Prevalence of coronary disease was 17·4% (2·1% for stroke and 5·2% for peripheral artery disease), increasing with concentrations of untreated LDL cholesterol, and was about two times lower in women than in men. Among patients receiving lipid-lowering medications, 16 803 (81·1%) were receiving statins and 3691 (21·2%) were on combination therapy, with greater use of more potent lipid-lowering medication in men than in women. Median LDL cholesterol
AU  - Vallejo-Vaz,AJ
AU  - Stevens,CAT
AU  - Lyons,ARM
AU  - Dharmayat,KI
AU  - Freiberger,T
AU  - Hovingh,GK
AU  - Mata,P
AU  - Raal,FJ
AU  - Santos,RD
AU  - Soran,H
AU  - Watts,GF
AU  - Abifadel,M
AU  - Aguilar-Salinas,CA
AU  - Alhabib,KF
AU  - Alkhnifsawi,M
AU  - Almahmeed,W
AU  - Alnouri,F
AU  - Alonso,R
AU  - Al-Rasadi,K
AU  - Al-Sarraf,A
AU  - Al-Sayed,N
AU  - Araujo,F
AU  - Ashavaid,TF
AU  - Banach,M
AU  - Béliard,S
AU  - Benn,M
AU  - Binder,CJ
AU  - Bogsrud,MP
AU  - Bourbon,M
AU  - Chlebus,K
AU  - Corral,P
AU  - Davletov,K
AU  - Descamps,OS
AU  - Durst,R
AU  - Ezhov,M
AU  - Gaita,D
AU  - Genest,J
AU  - Groselj,U
AU  - Harada-Shiba,M
AU  - Holven,KB
AU  - Kayikcioglu,M
AU  - Khovidhunkit,W
AU  - Lalic,K
AU  - Latkovskis,G
AU  - Laufs,U
AU  - Liberopoulos,E
AU  - Lima-Martinez,MM
AU  - Lin,J
AU  - Maher,V
AU  - Marais,AD
AU  - März,W
AU  - Mirrakhimov,E
AU  - Miserez,AR
AU  - Mitchenko,O
AU  - Nawawi,H
AU  - Nordestgaard,BG
AU  - Panayiotou,AG
AU  - Paragh,G
AU  - Petrulioniene,Z
AU  - Pojskic,B
AU  - Postadzhiyan,A
AU  - Raslova,K
AU  - Reda,A
AU  - Reiner,
AU  - Sadiq,F
AU  - Sadoh,WE
AU  - Schunkert,H
AU  - Shek,AB
AU  - Stoll,M
AU  - Stroes,E
AU  - Su,T-C
AU  - Subramaniam,T
AU  - Susekov,AV
AU  - Tilney,M
AU  - Tomlinson,B
AU  - Truong,TH
AU  - Tselepis,AD
AU  - Tybjæg-Hansen,A
AU  - Vázquez,Cárdenas A
AU  - Viigimaa,M
AU  - Wang,L
AU  - Yamashita,S
AU  - Tokgozoglu,L
AU  - Catapano,AL
AU  - Ray,KK
AU  - Kastelein,JJP
AU  - Bruckert,E
AU  - Vohnout,B
AU  - Schreier,L
AU  - Pang,J
AU  - Ebenbichler,C
AU  - Dieplinger,H
AU  - Innerhofer,R
AU  - Winhofer-Stöckl,Y
AU  - Greber-Platzer,S
AU  - Krychtiuk,K
AU  - Speidl,W
AU  - Toplak,H
AU  - Widhalm,K
AU  - Stulnig,T
AU  - Huber,K
AU  - Höllerl,F
AU  - Rega-Kaun,G
AU  - Kleemann,L
AU  - Mäser,M
AU  - Scholl-Bürgi,S
AU  - Säly,C
AU  - Mayer,FJ
AU  - Sablon,G
AU  - Tarantino,E
AU  - Nzeyimana,C
AU  - Pojskic,L
AU  - Sisic,I
AU  - Nalbantic,AD
AU  - Jannes,CE
AU  - Pereira,AC
AU  - Krieger,JE
AU  - Petrov,I
AU  - Goudev,A
AU  - Nikolov,F
AU  - Tisheva,S
AU  - Yotov,Y
AU  - Tzvetkov,I
AU  - Baass,A
AU  - Bergeron,J
AU  - Bernard,S
AU  - Brisson,D
AU  - Brunham,LR
AU  - Cermakova,L
AU  - Couture,P
AU  - Francis,GA
AU  - Gaudet,D
AU  - Hegele,RA
AU  - Khoury,E
AU  - Mancini,GBJ
AU  - McCrindle,BW
AU  - Paquette,M
AU  - Ruel,I
AU  - Cuevas,A
AU  - Asenjo,S
AU  - Wang,X
AU  - Meng,K
AU  - Song,X
AU  - Yong,Q
AU  - Jiang,T
AU  - Liu,Z
AU  - Duan,Y
AU  - Hong,J
AU  - Ye,P
AU  - Chen,Y
AU  - Qi,J
AU  - Liu,Z
AU  - Li,Y
AU  - Zhang,C
AU  - Peng,J
AU  - Yang,Y
AU  - Yu,W
AU  - Wang,Q
AU  - Yuan,H
AU  - Cheng,S
AU  - Jiang,L
AU  - Chong,M
AU  - Jiao,J
AU  - Wu,Y
AU  - Wen,W
AU  - Xu,L
AU  - Zhang,R
AU  - Qu,Y
AU  - He,J
AU  - Fan,X
AU  - Wang,Z
AU  - Chow,E
AU  - Pein,I
AU  - Perica,D
AU  - Symeonides,P
AU  - Vrablik,M
AU  - Ceska,R
AU  - Soska,V
AU  - Tichy,L
AU  - Adamkova,V
AU  - Franekova,J
AU  - Cifkova,R
AU  - Kram
DO  - 10.1016/s0140-6736(21)01122-3
EP  - 1725
PY  - 2021///
SN  - 0140-6736
SP  - 1713
TI  - Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)
T2  - The Lancet
UR  - http://dx.doi.org/10.1016/s0140-6736(21)01122-3
UR  - https://www.sciencedirect.com/science/article/pii/S0140673621011223?via%3Dihub
UR  - http://hdl.handle.net/10044/1/91645
VL  - 398
ER  -

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Dr. Alexander R.M. Lyons, Ph.D

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